Can a common antioxidant shield kidneys from a powerful antibiotic?
NCT ID NCT07668141
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether taking alpha-lipoic acid, an antioxidant, can protect the kidneys of hospitalized patients who need the strong antibiotic colistin. Colistin can cause kidney damage, and researchers want to see if this supplement lowers that risk. The trial will involve 88 adults with multidrug-resistant infections and will use a urine biomarker to detect early kidney injury.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- alpha-lipoic acid
- What this could lead to
- If it works, this could offer a simple way to protect kidneys during colistin treatment, reducing the risk of acute kidney injury.
- What could go wrong
- This is a small, early-phase trial with only 88 participants. The benefit seen in animal studies may not translate to humans, and alpha-lipoic acid may not prevent kidney damage in all patients.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
6th October Hospital-Dokki-General Authority for Health Insurance Organization
Giza, Egypt
-
Al-Haram Hospital
Giza, Egypt
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