Old drug, new hope: cabergoline trial targets endometriosis pain

NCT ID NCT03928288

Completed Symptom relief Sponsor: Boston Children's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether cabergoline, a drug already used for other conditions, can reduce chronic pain in women and teens with endometriosis. 129 participants took either cabergoline or a placebo for 6 months. The goal was to see if this non-hormonal approach could safely ease pain without the side effects of standard hormone therapies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cabergoline (Dostinex)
What this could lead to: If it works, this could offer a new, non-hormonal option to ease chronic pain from endometriosis, avoiding side effects of current treatments.
What could go wrong: This is a phase 2 trial with 129 participants, so results are preliminary. The drug may not prove effective or could have side effects not yet seen.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

endometriosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIOSIS

Contacts and locations

Locations

Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02115, United States
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
Children's Hospital Boston

Boston, Massachusetts, 02115, United States
Childrens Hospital Colorado

Aurora, Colorado, 80045, United States
Standford University

Palo Alto, California, 94305, United States
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States

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