New pill combo shows promise for tough brain cancer

NCT ID NCT03328078

Recruiting now Disease control Sponsor: Curis, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests an experimental oral drug called emavusertib (CA-4948), taken alone or with ibrutinib, in adults with relapsed or refractory primary central nervous system lymphoma (PCNSL). The trial has multiple parts to find the safest dose and see if the drug shrinks tumors. About 152 participants will be enrolled across several centers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Emavusertib (also called CA-4948) taken as a tablet, alone or with another drug called ibrutinib.

What this could lead to

If successful, this could offer a new oral treatment option for patients with a hard-to-treat brain lymphoma that has come back or not responded to other therapies.

What could go wrong

This is an early-phase trial (Phase 1/2) with a small number of participants, so the drug may not work as hoped or could have serious side effects. It is not yet proven to be safe or effective.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

hematopoietic and lymphoid system neoplasm immune system disorder immunoproliferative disorder lymphatic system disorder lymphoma lymphoproliferative syndrome neoplasm non-Hodgkin lymphoma primary central nervous system lymphoma Recurrence refractory hematologic cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

REFRACTORY HEMATOLOGIC MALIGNANCY REFRACTORY PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA RELAPSED HEMATOLOGIC MALIGNANCY RELAPSED PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

City of Hope
RECRUITING

Duarte, California, 91010, United States
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Columbia University Irving Medical Center
WITHDRAWN

New York, New York, 10032, United States
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Duke University Medical Center, Duke Cancer Center
RECRUITING

Durham, North Carolina, 27710, United States
Fred and Pamela Buffett Cancer Center
RECRUITING

Omaha, Nebraska, 68198, United States
Hackensack University Medical Center
COMPLETED

Hackensack, New Jersey, 07601, United States
Hadassah Medical Center / Ein-Carem
RECRUITING

Jerusalem, Israel
Hematology Department Soroka UMC / Heanatology Department
RECRUITING

Beersheba, Israel
Hopital de la Timone
RECRUITING

Marseille, France
Hospital Pitie Salpetriere
RECRUITING

Paris, France
Hospital Universitario Virgen del Rocio
RECRUITING

Seville, Spain
Hospital of the University of Pennsylvania
COMPLETED

Philadelphia, Pennsylvania, 19104, United States
Huntsman Cancer Institute, University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States
IRCCS San Raffaele Scientific Institute
RECRUITING

Milan, Italy
IRST - Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
RECRUITING

Meldola, Italy
Institut Bergonie
RECRUITING

Bordeaux, France
Institut Curie Hospital
RECRUITING

Paris, France
MD Anderson Cancer Center Madrid
RECRUITING

Madrid, Spain
Mayo Clinic
COMPLETED

Phoenix, Arizona, 85054, United States
Mayo Clinic
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Mt Sinai
RECRUITING

New York, New York, 10029, United States
NarodowyInstytutu Onkologii im. Marii Sklodowskiej-Curie-Panstwowy Instytutu Badawczy
RECRUITING

Warsaw, Poland
Northwestern Memorial Hospital
RECRUITING

Chicago, Illinois, 60611, United States
Oddzial Kliniczny Hematologii
WITHDRAWN

Krakow, Poland
Providence Neurological Specialties West
RECRUITING

Portland, Oregon, 97225, United States
Providence St. John's Health Center
RECRUITING

Santa Monica, California, 90404, United States
Rambam Medical Center
RECRUITING

Haifa, Israel
Roswell Park Comprehensive Cancer Center
RECRUITING

Buffalo, New York, 14263, United States
SODc Ematologia Azienda Ospedaliera Universitaria Careggi
RECRUITING

Florence, Italy
Smilow Cancer Hospital at Yale-New Haven
COMPLETED

New Haven, Connecticut, 06510, United States
St. Joseph's Hospital and Medical Center
RECRUITING

Phoenix, Arizona, 85013, United States
Swedish Cancer Institute
COMPLETED

Seattle, Washington, 98104, United States
The University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
UCLA Department of Medicine - Hematology/Oncology
WITHDRAWN

Santa Monica, California, 90404, United States
UPMC Hilman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
UT Southwestern Medical Center
ACTIVE_NOT_RECRUITING

Dallas, Texas, 75235, United States
University Hospital Vall d'Hebron
RECRUITING

Barcelona, Spain
University of Tennessee Medical Center
COMPLETED

Knoxville, Tennessee, 37920, United States
University of Washington Medical Center
RECRUITING

Seattle, Washington, 98195, United States
Università di Torino Croce e Carle
RECRUITING

Cuneo, Italy
Uniwersyteckie Centrum Kliniczne Osrodek Badan Klinicznych Wczesnych Faz
RECRUITING

Gdansk, Poland
Všeobecná fakultní nemocnice v Praze
RECRUITING

Prague, Czechia