New Antibody-Drug conjugate takes aim at Hard-to-Treat leukemia

NCT ID NCT06359002

First seen Jan 28, 2026 · Last updated May 23, 2026 · Updated 14 times

Summary

This early-stage trial tests a new drug called BYON4413 in 16 people whose acute myeloid leukemia (AML) or myelodysplastic neoplasms (MDS) have returned or not responded to standard treatments. The drug is an antibody-drug conjugate designed to deliver a toxic payload directly to cancer cells. The main goals are to check safety and find the right dose, while also looking for signs that the drug can shrink or eliminate the cancer.

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Contacts and locations

Locations

  • Het Ziekenhuisnetwerk Antwerpen

    Antwerp, Belgium

  • Hospital Clinic de Barcelona

    Barcelona, Spain

  • Hospital San Pedro de Alcantara

    Cáceres, Spain

  • Hospital Universitario de Salamanca

    Salamanca, Spain

  • Hospital Universitario y Politecnico La Fe

    Valencia, Spain

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, Spain

  • Institut Catala d'Oncologia

    Badalona, Spain

  • UZ Leuven

    Leuven, Belgium

  • Universitair Medisch Centrum Groningen

    Groningen, Netherlands

Conditions

Explore the condition pages connected to this study.