New drug cocktail aims to stop esophageal cancer from coming back

NCT ID NCT05480384

First seen Jan 07, 2026 · Last updated May 13, 2026 · Updated 20 times

Summary

This study looks at whether a 1-year treatment with two drugs (Enhertu and nivolumab) can safely prevent cancer from returning in people with HER2-positive esophageal or stomach-junction cancer. Participants have already completed standard therapy (chemoradiation and surgery) but still had some cancer cells left. The main goal is to check for serious side effects and see how long people stay cancer-free.

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Contacts and locations

Locations

  • Lifespan Cancer Institute

    Providence, Rhode Island, 02903, United States

  • Weill Cornell Medicine/New York-Presbyterian

    New York, New York, 10021, United States

Conditions

Explore the condition pages connected to this study.