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Breathing new life: could targeted muscle training speed stroke recovery?

NCT ID NCT07770776

Symptom relief Sponsor: Prof. R. D. Kandou General Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 18, 2026 · Last updated Aug 19, 2026 · Updated 1 time

Summary

This trial tests whether a high-intensity breathing exercise program, started within days of an acute stroke, can strengthen the muscles used for breathing and speech. Hospitalized stroke patients will be randomly assigned to either this new training or conventional diaphragmatic breathing exercises. Researchers will measure changes in inspiratory and expiratory muscle strength, chest expansion, and breath-holding capacity to see if the new approach offers greater early benefits.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
High-intensity interval inspiratory and expiratory muscle training using a breathing device
What this could lead to
If effective, this training could become a standard early rehabilitation approach to improve breathing and speech endurance in stroke patients.
What could go wrong
This is a small, early-phase trial with only 24 participants, so results may not apply broadly. The training is intense and may be challenging for some patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

24 people

The number who actually took part.

Started

Apr 2026

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female participants aged 18 years or older. * First-ever acute ischemic stroke, with stroke onset 2 to 14 days before enrollment, confirmed by computed tomography (CT) or magnetic resonance imaging (MRI). * National Institutes of Health Stroke Scale (NIHSS) score ≥5, with the presence of hemiparesis. * Baseline maximal inspiratory pressure (MIP) \<80 cmH₂O. * Baseline maximal expiratory pressure (MEP) \<68 cmH₂O. * Able to understand instructions and participate in the respiratory muscle training program. * Willing to comply with the study protocol and provide written informed consent. Exclusion Criteria: * Resting blood pressure \>160/100 mmHg. * Resting peripheral oxygen saturation (SpO₂) \<92%. * Resting heart rate \<40 beats/min or \>110 beats/min. * Fever, defined as body temperature ≥37.5°C. * Previous participation in or experience with a respiratory muscle training program. * Presence of chronic pulmonary disease. * Presence of a tracheostomy tube. * Presence of unstable cardiac disease. * Presence of another neurological disorder associated with respiratory dysfunction. * Presence of an orthopedic or musculoskeletal condition that significantly interferes with respiratory function or the ability to perform respiratory muscle training. * History of major thoracic or abdominal surgery within the previous 3 months.

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Conditions

The condition(s) this trial relates to.

ischemic stroke stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute stroke Expiratory muscle training Inspiratory muscle strength Inspiratory muscle training Respiratory muscle strength Respiratory muscle training Stroke

Contacts and locations

Locations

  • Prof. R. D. Kandou General Hospital

    Manado, North Sulawesi, Indonesia

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