Direct-to-Brain attack on deadly breast cancer spread

NCT ID NCT01373710

Summary

This study tested whether delivering the breast cancer drug trastuzumab (Herceptin) directly into the spinal fluid could help patients whose cancer had spread to the membranes around the brain and spinal cord. The trial involved 34 people with advanced HER2-positive breast cancer that had developed this serious complication. Researchers first determined a safe dose, then looked at whether this direct delivery method could delay neurological problems and control the cancer in the nervous system.

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Contacts and locations

Locations

  • CHU Grenoble

    Grenoble, 38700, France

  • François Baclesse Center

    Caen, Calvados, 14076, France

  • Institut Bergonié

    Bordeaux, 33076, France

  • Institut Curie - Claudius Regaud Hospital

    Paris, Île-de-France Region, 75248, France

  • Institut Univesitaire du Cancer de Toulouse

    Toulouse, 31100, France

  • Institut du Cancer de Montpellier

    Montpellier, 34298, France

  • Léon Bérard Center

    Lyon, Rhone, 69373, France

  • Oscar Lambret Center

    Lille, Nord, 59020, France

  • Pitie Salpetriere Hospital

    Paris, Île-de-France Region, 75651, France

  • Rene Huguenin Hospital

    Saint-Cloud, Haut de Seine, 92210, France

Conditions

Explore the condition pages connected to this study.