New drug combo tested to shrink tumors before breast cancer surgery
NCT ID NCT04425018
Summary
This study compares two different drug combinations given before surgery to shrink tumors in people with stage II-III HER2-positive breast cancer. About 174 participants were randomly assigned to receive either a newer drug combination (margetuximab) or the standard combination (trastuzumab), both given with two other drugs. The main goal is to see which combination leads to more patients having no detectable cancer left at surgery.
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Contacts and locations
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Locations
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Baylor College of Medicine Medical Center
Houston, Texas, 77030, United States
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Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
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Dana Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Dana-Farber Brigham Cancer Center - Foxborough
Foxborough, Massachusetts, 02035, United States
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Dana-Farber at Milford
Milford, Massachusetts, 01757, United States
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Dana-Farber at South Shore Hospital
Weymouth, Massachusetts, 02190, United States
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Georgetown University Medical Center
Washington D.C., District of Columbia, 20007, United States
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MD Anderson Cancer Center
Houston, Texas, 77030, United States
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MedStar Washington Hospital Center
Washington D.C., District of Columbia, 20010, United States
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Montefiore Medical Center
The Bronx, New York, 10461, United States
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UPMC Hillman Cancer Center - Arnold Palmer at Mountain View
Greensburg, Pennsylvania, 15601, United States
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UPMC Hillman Cancer Center - Arnold Palmer at Norwin
Irwin, Pennsylvania, 15642, United States
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University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15213, United States
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University of Washington Fred Hutchinson Cancer Care
Seattle, Washington, 98109, United States
Conditions
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