CLL patients may get a break: new combo aims for deep remission

NCT ID NCT06524375

First seen Oct 31, 2025 · Last updated May 08, 2026 · Updated 25 times

Summary

This study looks at whether adding the drug venetoclax to standard BTK inhibitor therapy can help people with chronic lymphocytic leukemia (CLL) reach very deep remission. The goal is to allow patients to stop all treatment for a period of time. About 118 adults who have been on a BTK inhibitor for at least 6 months will take part. The study is active but no longer recruiting new participants.

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Contacts and locations

Locations

  • American Oncology Partners of Maryland, PA

    Bethesda, Maryland, 20817-1915, United States

  • Asante Rogue Regional Medical Center

    Medford, Oregon, 97504-8332, United States

  • Astera Cancer Care East Brunswick

    East Brunswick, New Jersey, 08816-4096, United States

  • Cancer Specialists of North Florida

    Jacksonville, Florida, 32256-6932, United States

  • Dana-Farber Cancer Institute - Hematologic Oncology Treatment Center

    Boston, Massachusetts, 02215-5418, United States

  • Fort Wayne Medical Oncology and Hematology, Inc

    Fort Wayne, Indiana, 46804, United States

  • Highlands Oncology Group

    Springdale, Arkansas, 72762, United States

  • MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Mission Blood and Cancer - MercyOne Cancer Center

    Des Moines, Iowa, 50314-3030, United States

  • Nebraska Cancer Specialists

    Omaha, Nebraska, 68130-2042, United States

  • Nebraska Cancer Specialists St Francis - Grand Island

    Grand Island, Nebraska, 68803, United States

  • Ohio State University

    Columbus, Ohio, 43210, United States

  • Oncology Hematology Care Inc - Cincinnati - USOR

    Cincinnati, Ohio, 45236-2725, United States

  • Rocky Mountain Cancer Centers (Aurora) - USOR

    Aurora, Colorado, 80012-5405, United States

  • San Juan Oncology Associates, PC

    Farmington, New Mexico, 87401, United States

  • Tennessee Oncology - Midtown

    Nashville, Tennessee, 37203, United States

  • Tennessee Oncology, PLLC - Chattanooga

    Chattanooga, Tennessee, 37404, United States

  • Texas Oncology- Northeast Texas

    Tyler, Texas, 75702, United States

  • Willamette Valley Cancer Institute and Research Center

    Eugene, Oregon, 97401-6043, United States

Conditions

Explore the condition pages connected to this study.