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Broccoli vs hot flashes: diet put to the test in breast cancer survivors

NCT ID NCT07842614

Symptom relief Sponsor: Azienda Ospedaliero, Universitaria Pisana Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 25, 2026 · Last updated Sep 25, 2026

Summary

Researchers are testing whether eating more Brassicaceae vegetables, such as broccoli, cabbage, cauliflower and Brussels sprouts, can reduce hot flashes and night sweats in women who have had hormone-sensitive breast cancer and take anti-estrogen therapy. About 81 women are randomly assigned to receive nutritional counseling to eat at least five servings of these vegetables each week, or to a control group that gets standard nutritional assessment without that specific advice. The study compares vasomotor symptom scores, other menopausal symptoms, body measurements, blood pressure and blood markers at the start and after 3 and 6 months, with telephone follow-up to 18 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A diet with at least five weekly servings of Brassicaceae vegetables such as broccoli, cabbage, cauliflower and Brussels sprouts
What this could lead to
If it works, a simple dietary change could give women on anti-estrogen therapy a low-risk way to ease hot flashes and night sweats.
What could go wrong
Diet studies are hard to control, and participants may not stick to the advice. Any benefit could be small or explained by other diet and lifestyle factors rather than the vegetables themselves.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

81 people

The number who actually took part.

Started

Oct 2020

Finished

Oct 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Women with a histological diagnosis of hormone-sensitive breast cancer * Adjuvant anti-estrogen therapy (tamoxifen, LH-RH analogue, aromatase inhibitors) initiated at least 6 months prior to enrollment * Women aged 18 to 60 years * Patient willingness to continue hormonal therapy for the duration of the study * Spontaneous or induced amenorrhea within the last 6 months * Women experiencing 6 or more hot flashes per day or scoring at least 15 on the Greene Climacteric Scale (GCS) in the week prior to enrollment * Willingness to participate and follow nutritional guidelines (applicable only to the nutritional intervention arm) after signing informed consent * Performance status ≤1 Exclusion Criteria: * women with a prior diagnosis of severe and pharmacologically uncontrolled depression, osteoporosis, hypercholesterolemia, and/or hypertension * allergy or intolerance to vegetables of the Brassicaceae family (applicable only to the nutritional intervention arm) * women with reported thyroid disorders * women using serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors (venlafaxine), or anticonvulsants (gabapentin and gabatrin) * ongoing chemotherapy or radiotherapy

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm hormone receptor-positive breast cancer Hot Flashes

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Breast cancer Menopausal symptoms

Contacts and locations

Locations

  • Azienda Ospedaliero-Universitaria Pisana, U.O. Senologia

    Pisa, Tuscany, 56126, Italy

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