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Scientists hunt for a brain wave that reveals why One-Sided deafness wrecks sound location

NCT ID NCT03632551

NEW Knowledge-focused Sponsor: University Hospital, Toulouse Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 21, 2026 · Last updated Sep 21, 2026

Summary

Researchers want to know whether a specific brain wave, called mismatch negativity, can serve as a marker for problems locating sound. They will compare three groups: people with normal hearing, people with single-sided deafness, and people with a cochlear implant in one ear. Participants complete hearing tests that measure how well they locate sounds and understand speech in noise, along with an EEG to record brain activity. The goal is to understand the brain basis of spatial hearing difficulties, not to test a treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If researchers can link a specific brain signal to sound localization problems, it could guide better hearing rehabilitation for people with single-sided deafness or cochlear implants.
What could go wrong
This is an observational study with no treatment, so it will not restore hearing. The findings may not translate into new therapies, and the brain signal may not reliably reflect real-world listening difficulties.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

91 people

The number who actually took part.

Started

Jul 2018

Finished

Jul 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: For symmetrical hearing subjects: * Affiliation to a social security * Normal hearing, or mild to moderate symmetrical hearing loss controlled by tone audiometry performed before inclusion (in air conduction and bone conduction, frequencies 250 Hz to 4000 Hz). * Signature of the consent form For subjects with single-sided deafness: * Affiliation to a social security * Subject having a unilateral deafness controlled by pure-tone audiometry before inclusion (in air conduction and bone conduction, frequencies 250 Hz to 4000 Hz). * Signature of the consent form For subjects with Cochlear Implants: * Affiliation to a social security * Subject with symmetrical or asymmetrical profound deafness treated by unilateral cochlear implantation. * Signature of the consent form Exclusion Criteria: * History of associated neurological disorder * Taking psychotropic drugs * Persons with complicated social or medical situations

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Conditions

The condition(s) this trial relates to.

Deafness deafness, unilateral hearing loss disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Deafness

Contacts and locations

Locations

  • Oto rhino laryngologie

    Toulouse, France

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