New hope for kids with devastating brain tumors: trial tests flexible drug combinations
NCT ID NCT05009992
Summary
This trial is testing new drug combinations for children and young adults with aggressive brain tumors called diffuse midline gliomas (DMGs), which currently have very few treatment options. It uses a flexible 'platform' design to test different drug combinations, including ONC201 and a virus-based therapy called DNX-2401, at different stages of the disease. The main goals are to see if these combinations can help control the tumor for longer and are safe for patients.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
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Locations
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Ann & Robert H. Lurie Children's Hospital of Chicago
RECRUITINGChicago, Illinois, 60611, United States
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Children's Hospital Los Angeles
RECRUITINGLos Angeles, California, 90027, United States
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Children's Hospital Minnesota
RECRUITINGMinneapolis, Minnesota, 55404, United States
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Children's Hospital of Philadelphia
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Children's National Hospital
RECRUITINGWashington D.C., District of Columbia, 20010, United States
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Dana-Farber Cancer Institute Harvard University
RECRUITINGBoston, Massachusetts, 02215-6024, United States
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Duke University
RECRUITINGDurham, North Carolina, 27708, United States
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Hackensack Meridian Health
RECRUITINGHackensack, New Jersey, 07601, United States
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Indiana University Riley Children's Hospital
RECRUITINGIndianapolis, Indiana, 46202, United States
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John Hunter Children's Hospital
RECRUITINGNew Lambton Heights, New South Wales, 2305, Australia
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Johns Hopkins University
RECRUITINGBaltimore, Maryland, 21287, United States
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Monash Children's Hospital
RECRUITINGClayton, Victoria, 3168, Australia
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Nationwide Children's Hospital
RECRUITINGColumbus, Ohio, 43205, United States
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New York University
RECRUITINGNew York, New York, 10016, United States
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Perth Children's Hospital
RECRUITINGNedlands, Washington, 6009, Australia
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Princess Maxima Center
ACTIVE_NOT_RECRUITINGUtrecht, Netherlands
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Queensland Children's Hospital
RECRUITINGSouth Brisbane, Queensland, Australia
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Seattle Children's Hospital
RECRUITINGSeattle, Washington, 98101, United States
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Shaare Zedek Medical Center
RECRUITINGJerusalem, 9103102, Israel
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Sheba Medical Center
RECRUITINGTel Litwinsky, Ramat Gan, Israel
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Starship Children's Hospital
RECRUITINGAuckland, New Zealand
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Sydney Children's Hospital
RECRUITINGSydney, 2031, Australia
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The Children's Hospital at Westmead
RECRUITINGWestmead, New South Wales, 2152, Australia
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The Royal Children's Hospital Melbourne
RECRUITINGMelbourne, Victoria, 3052, Australia
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The University Children's Hospital in Zurich
RECRUITINGZurich, Switzerland
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University of Alabama at Birmingham
RECRUITINGBirmingham, Alabama, 35233, United States
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University of California, San Diego / Rady Children's Hospital, San Diego
RECRUITINGSan Diego, California, 92123, United States
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University of California, San Francisco
RECRUITINGSan Francisco, California, 94143, United States
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University of Michigan
RECRUITINGAnn Arbor, Michigan, 48109, United States
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University of Utah
RECRUITINGSalt Lake City, Utah, 84101, United States
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Washington University in St. Louis
RECRUITINGSt Louis, Missouri, 63110, United States
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Women and Children's Hospital
RECRUITINGAdelaide, Australia
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Conditions
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