New MRI technique may help doctors see if brain tumor treatment is working sooner

NCT ID NCT03115333

Ongoing Knowledge-focused Sponsor: ECOG-ACRIN Cancer Research Group Source: ClinicalTrials.gov ↗

First seen Sep 30, 2025 · Last updated May 16, 2026 · Updated 25 times

Summary

This study looks at whether a special type of MRI (DSC-MRI) can measure blood flow changes in brain tumors to quickly tell if a drug called bevacizumab is working. About 146 adults with recurrent glioblastoma will get the MRI before and after starting treatment. The goal is to see if early changes in blood flow can predict survival, helping doctors make faster treatment decisions.

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Contacts and locations

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Locations

Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin, 53215, United States
Baptist Health Lexington

Lexington, Kentucky, 40503, United States
Baptist MD Anderson Cancer Center

Jacksonville, Florida, 32207, United States
Boca Raton Regional Hospital

Boca Raton, Florida, 33486, United States
Carolinas Medical Center/Levine Cancer Institute

Charlotte, North Carolina, 28203, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
East Carolina University

Greenville, North Carolina, 27834, United States
Eden Hospital Medical Center

Castro Valley, California, 94546, United States
Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322, United States
Froedtert Menomonee Falls Hospital

Menomonee Falls, Wisconsin, 53051, United States
Froedtert West Bend Hospital/Kraemer Cancer Center

West Bend, Wisconsin, 53095, United States
Henry Ford Hospital

Detroit, Michigan, 48202, United States
IU Health Methodist Hospital

Indianapolis, Indiana, 46202, United States
Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, 46202, United States
Loma Linda University Medical Center

Loma Linda, California, 92354, United States
Maryland Proton Treatment Center

Baltimore, Maryland, 21201, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Mayo Clinic Hospital

Phoenix, Arizona, 85054, United States
Mayo Clinic in Arizona

Scottsdale, Arizona, 85259, United States
Mayo Clinic in Florida

Jacksonville, Florida, 32224-9980, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Memorial Hermann Texas Medical Center

Houston, Texas, 77030, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Commack

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Westchester

East White Plains, New York, 10604, United States
Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, 55109, United States
Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota, 55125, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Moffitt Cancer Center - McKinley Campus

Tampa, Florida, 33612, United States
Moffitt Cancer Center-International Plaza

Tampa, Florida, 33607, United States
Northside Hospital

Atlanta, Georgia, 30342, United States
Northside Hospital-Forsyth

Cumming, Georgia, 30041, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
ProHealth D N Greenwald Center

Mukwonago, Wisconsin, 53149, United States
ProHealth Oconomowoc Memorial Hospital

Oconomowoc, Wisconsin, 53066, United States
ProHealth Waukesha Memorial Hospital

Waukesha, Wisconsin, 53188, United States
Regions Hospital

Saint Paul, Minnesota, 55101, United States
Rhode Island Hospital

Providence, Rhode Island, 02903, United States
Saint Joseph's Hospital and Medical Center

Phoenix, Arizona, 85013, United States
Siteman Cancer Center at Saint Peters Hospital

City of Saint Peters, Missouri, 63376, United States
Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, 63141, United States
Siteman Cancer Center-South County

St Louis, Missouri, 63129, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, 92868, United States
UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599, United States
USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States
UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390, United States
UW Cancer Center at ProHealth Care

Waukesha, Wisconsin, 53188, United States
United Hospital

Saint Paul, Minnesota, 55102, United States
University Hospital

San Antonio, Texas, 78229, United States
University of Cincinnati/Barrett Cancer Center

Cincinnati, Ohio, 45219, United States
University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, 21201, United States
University of Missouri - Ellis Fischel

Columbia, Missouri, 65212, United States
University of New Mexico Cancer Center

Albuquerque, New Mexico, 87102, United States
University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229, United States
VA Palo Alto Health Care System

Palo Alto, California, 94304, United States
Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.

GLIOSARCOMA RECURRENT GLIOBLASTOMA