New brain zaps could lift depression when pills fail

NCT ID NCT07329153

First seen Jan 11, 2026 · Last updated May 14, 2026 · Updated 23 times

Summary

This study tests a quick, non-invasive brain stimulation technique called accelerated intermittent theta-burst stimulation (aiTBS) for people with depression that hasn't improved with at least two medications. About 247 adults aged 18-65 will be randomly assigned to receive either a personalized, computer-guided version of the treatment, a standard version, or a fake (sham) version. The goal is to see if these brain stimulation methods can safely reduce depression symptoms better than a placebo.

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Contacts and locations

Locations

  • Cornell University

    New York, New York, 10065, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of California at San Diego (UCSD)

    San Diego, California, 92127, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Texas Southwestern Medical Center

    Dallas, Texas, 75390, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.