Brain cancer radiation showdown: one big zap vs. several small ones

NCT ID NCT04114981

Ongoing Disease control Sponsor: Alliance for Clinical Trials in Oncology Source: ClinicalTrials.gov ↗

Summary

This study compares two ways of delivering targeted radiation after surgery to remove cancer that has spread to the brain. It tests whether giving one high-dose treatment is as good as, or worse than, giving several smaller doses over a few days. The goal is to see which method better prevents the cancer from coming back in the same spot and leads to a better quality of life for patients.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States
Anchorage Radiation Therapy Center

Anchorage, Alaska, 99504, United States
Ascension All Saints Hospital

Racine, Wisconsin, 53405, United States
Ascension Columbia Saint Mary's Hospital - Milwaukee

Milwaukee, Wisconsin, 53211, United States
Ascension Providence Hospitals - Novi

Novi, Michigan, 48374, United States
Ascension Saint Francis - Reiman Cancer Center

Franklin, Wisconsin, 53132, United States
Ascension Saint Mary's Hospital

Saginaw, Michigan, 48601, United States
Ascension Southeast Wisconsin Hospital - Elmbrook Campus

Brookfield, Wisconsin, 53045, United States
Aspirus Regional Cancer Center

Wausau, Wisconsin, 54401, United States
Aurora BayCare Medical Center

Green Bay, Wisconsin, 54311, United States
Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin, 53215, United States
Banner MD Anderson Cancer Center

Gilbert, Arizona, 85234, United States
Banner Thunderbird Medical Center

Glendale, Arizona, 85306, United States
Banner-University Medical Center Phoenix

Phoenix, Arizona, 85006, United States
Baptist Memorial Hospital and Cancer Center-Memphis

Memphis, Tennessee, 38120, United States
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, Texas, 77030, United States
Beebe Health Campus

Rehoboth Beach, Delaware, 19971, United States
Benefis Healthcare- Sletten Cancer Institute

Great Falls, Montana, 59405, United States
Billings Clinic Cancer Center

Billings, Montana, 59101, United States
Billings Clinic-Cody

Cody, Wyoming, 82414, United States
Boca Raton Regional Hospital

Boca Raton, Florida, 33486, United States
Bozeman Deaconess Hospital

Bozeman, Montana, 59715, United States
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)

Québec, Quebec, G1R 2J6, Canada
CHUM - Centre Hospitalier de l'Universite de Montreal

Montreal, Quebec, H2X 3E4, Canada
Cambridge Medical Center

Cambridge, Minnesota, 55008, United States
Cancer Care Center of O'Fallon

O'Fallon, Illinois, 62269, United States
Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, 62526, United States
Cancer Center of Western Wisconsin

New Richmond, Wisconsin, 54017, United States
Capital Region Southwest Campus

Jefferson City, Missouri, 65109, United States
Carle Cancer Center

Urbana, Illinois, 61801, United States
Centralia Oncology Clinic

Centralia, Illinois, 62801, United States
Coborn Cancer Center at Saint Cloud Hospital

Saint Cloud, Minnesota, 56303, United States
Community Hospital of Anaconda

Anaconda, Montana, 59711, United States
Community Medical Center

Toms River, New Jersey, 08755, United States
Community Medical Hospital

Missoula, Montana, 59804, United States
Cox Cancer Center Branson

Branson, Missouri, 65616, United States
CoxHealth South Hospital

Springfield, Missouri, 65807, United States
Cross Cancer Institute

Edmonton, Alberta, T6G 1Z2, Canada
Crossroads Cancer Center

Effingham, Illinois, 62401, United States
Decatur Memorial Hospital

Decatur, Illinois, 62526, United States
Delbert Day Cancer Institute at PCRMC

Rolla, Missouri, 65401, United States
Emory Saint Joseph's Hospital

Atlanta, Georgia, 30342, United States
Emory University Hospital Midtown

Atlanta, Georgia, 30308, United States
Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322, United States
Epic Care Cyberknife Center

Walnut Creek, California, 94597, United States
Fairview Clinics and Surgery Center Maple Grove

Maple Grove, Minnesota, 55369, United States
Fairview Lakes Medical Center

Wyoming, Minnesota, 55092, United States
Fairview Northland Medical Center

Princeton, Minnesota, 55371, United States
Fairview Ridges Hospital

Burnsville, Minnesota, 55337, United States
Fairview Southdale Hospital

Edina, Minnesota, 55435, United States
Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States
Fox Chase Cancer Center Buckingham

Furlong, Pennsylvania, 18925, United States
Freeman Health System

Joplin, Missouri, 64804, United States
Gibbs Cancer Center-Pelham

Greer, South Carolina, 29651, United States
Glens Falls Hospital

Glens Falls, New York, 12801, United States
Good Samaritan Regional Health Center

Mount Vernon, Illinois, 62864, United States
Great Falls Clinic

Great Falls, Montana, 59405, United States
Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601, United States
Guthrie Medical Group PC-Robert Packer Hospital

Sayre, Pennsylvania, 18840, United States
Health Partners Inc

Minneapolis, Minnesota, 55454, United States
Heartland Regional Medical Center

Saint Joseph, Missouri, 64506, United States
Helen F Graham Cancer Center

Newark, Delaware, 19713, United States
Hennepin County Medical Center

Minneapolis, Minnesota, 55415, United States
Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112, United States
Idaho Urologic Institute-Meridian

Meridian, Idaho, 83642, United States
Illinois CancerCare-Bloomington

Bloomington, Illinois, 61704, United States
Illinois CancerCare-Canton

Canton, Illinois, 61520, United States
Illinois CancerCare-Carthage

Carthage, Illinois, 62321, United States
Illinois CancerCare-Dixon

Dixon, Illinois, 61021, United States
Illinois CancerCare-Eureka

Eureka, Illinois, 61530, United States
Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401, United States
Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, 61443, United States
Illinois CancerCare-Macomb

Macomb, Illinois, 61455, United States
Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350, United States
Illinois CancerCare-Pekin

Pekin, Illinois, 61554, United States
Illinois CancerCare-Peoria

Peoria, Illinois, 61615, United States
Illinois CancerCare-Peru

Peru, Illinois, 61354, United States
Illinois CancerCare-Princeton

Princeton, Illinois, 61356, United States
Inova Schar Cancer Institute

Fairfax, Virginia, 22031, United States
Jewish General Hospital

Montreal, Quebec, H3T 1E2, Canada
Juravinski Cancer Centre at Hamilton Health Sciences

Hamilton, Ontario, L8V 5C2, Canada
Kalispell Regional Medical Center

Kalispell, Montana, 59901, United States
Karmanos Cancer Institute at McLaren Greater Lansing

Lansing, Michigan, 48910, United States
Kootenai Cancer Clinic

Sandpoint, Idaho, 83864, United States
Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, 83854, United States
Kootenai Health - Coeur d'Alene

Coeur d'Alene, Idaho, 83814, United States
Lakeview Hospital

Stillwater, Minnesota, 55082, United States
Legacy Good Samaritan Hospital and Medical Center

Portland, Oregon, 97210, United States
Lexington Medical Center

West Columbia, South Carolina, 29169, United States
Los Angeles County-USC Medical Center

Los Angeles, California, 90033, United States
M D Anderson Cancer Center

Houston, Texas, 77030, United States
Maine Medical Center- Scarborough Campus

Scarborough, Maine, 04074, United States
Mary Bird Perkins Cancer Center

Baton Rouge, Louisiana, 70809, United States
Mary Greeley Medical Center

Ames, Iowa, 50010, United States
Mayo Clinic Hospital in Arizona

Phoenix, Arizona, 85054, United States
Mayo Clinic in Arizona

Scottsdale, Arizona, 85259, United States
Mayo Clinic in Florida

Jacksonville, Florida, 32224-9980, United States
Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States
McFarland Clinic - Ames

Ames, Iowa, 50010, United States
McFarland Clinic - Boone

Boone, Iowa, 50036, United States
McFarland Clinic - Jefferson

Jefferson, Iowa, 50129, United States
McFarland Clinic - Marshalltown

Marshalltown, Iowa, 50158, United States
McFarland Clinic - Trinity Cancer Center

Fort Dodge, Iowa, 50501, United States
McLaren Cancer Institute-Bay City

Bay City, Michigan, 48706, United States
McLaren Cancer Institute-Flint

Flint, Michigan, 48532, United States
McLaren Cancer Institute-Macomb

Mount Clemens, Michigan, 48043, United States
McLaren Cancer Institute-Northern Michigan

Petoskey, Michigan, 49770, United States
McLaren-Port Huron

Port Huron, Michigan, 48060, United States
MedStar Franklin Square Medical Center/Weinberg Cancer Institute

Baltimore, Maryland, 21237, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Memorial Hermann Texas Medical Center

Houston, Texas, 77030, United States
Memorial Hospital of Carbondale

Carbondale, Illinois, 62902, United States
Memorial Medical Center

Springfield, Illinois, 62781, United States
Mercy Clinic-Rolla-Cancer and Hematology

Rolla, Missouri, 65401, United States
Mercy Hospital

Coon Rapids, Minnesota, 55433, United States
Mercy Hospital Fort Smith

Fort Smith, Arkansas, 72903, United States
Mercy Hospital Joplin

Joplin, Missouri, 64804, United States
Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, 73120, United States
Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States
Mercy Hospital South

St Louis, Missouri, 63128, United States
Mercy Hospital Springfield

Springfield, Missouri, 65804, United States
Mercy Hospital Washington

Washington, Missouri, 63090, United States
Methodist Medical Center of Illinois

Peoria, Illinois, 61636, United States
Miller-Dwan Hospital

Duluth, Minnesota, 55805, United States
Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, 55109, United States
Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota, 55125, United States
Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States
Missouri Baptist Outpatient Center-Sunset Hills

Sunset Hills, Missouri, 63127, United States
Missouri Baptist Sullivan Hospital

Sullivan, Missouri, 63080, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Monticello Cancer Center

Monticello, Minnesota, 55362, United States
Morton Plant Hospital

Clearwater, Florida, 33756, United States
Mount Sinai Chelsea

New York, New York, 10011, United States
Mount Sinai Hospital

New York, New York, 10029, United States
Mount Sinai West

New York, New York, 10019, United States
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro

Jonesboro, Arkansas, 72401, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, New York, 10032, United States
New Ulm Medical Center

New Ulm, Minnesota, 56073, United States
North Memorial Medical Health Center

Robbinsdale, Minnesota, 55422, United States
NorthShore University HealthSystem-Evanston Hospital

Evanston, Illinois, 60201, United States
Northeast Radiation Oncology Center

Dunmore, Pennsylvania, 18512, United States
Northwest Wisconsin Cancer Center

Ashland, Wisconsin, 54806, United States
Northwestern University

Chicago, Illinois, 60611, United States
Novant Health Forsyth Medical Center

Winston-Salem, North Carolina, 27103, United States
Novant Health Presbyterian Medical Center

Charlotte, North Carolina, 28204, United States
OSF Saint Francis Medical Center

Peoria, Illinois, 61637, United States
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center

Pekin, Illinois, 61554, United States
OSF Saint Francis Radiation Oncology at Peoria Cancer Center

Peoria, Illinois, 61615, United States
Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States
Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416, United States
Parkland Health Center - Farmington

Farmington, Missouri, 63640, United States
Parkland Health Center-Bonne Terre

Bonne Terre, Missouri, 63628, United States
Regions Hospital

Saint Paul, Minnesota, 55101, United States
Rice Memorial Hospital

Willmar, Minnesota, 56201, United States
Ridgeview Medical Center

Waconia, Minnesota, 55387, United States
Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903, United States
SIH Cancer Institute

Carterville, Illinois, 62918, United States
Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, 83706, United States
Saint Alphonsus Cancer Care Center-Caldwell

Caldwell, Idaho, 83605, United States
Saint Alphonsus Cancer Care Center-Nampa

Nampa, Idaho, 83687, United States
Saint Alphonsus Medical Center-Baker City

Baker City, Oregon, 97814, United States
Saint Alphonsus Medical Center-Ontario

Ontario, Oregon, 97914, United States
Saint Barnabas Medical Center

Livingston, New Jersey, 07039, United States
Saint Francis Cancer Center

Greenville, South Carolina, 29607, United States
Saint Francis Medical Center

Cape Girardeau, Missouri, 63703, United States
Saint Francis Regional Medical Center

Shakopee, Minnesota, 55379, United States
Saint John's Hospital - Healtheast

Maplewood, Minnesota, 55109, United States
Saint Joseph Mercy Brighton

Brighton, Michigan, 48114, United States
Saint Joseph Mercy Canton

Canton, Michigan, 48188, United States
Saint Joseph Mercy Chelsea

Chelsea, Michigan, 48118, United States
Saint Joseph Mercy Hospital

Ann Arbor, Michigan, 48106, United States
Saint Joseph's Hospital/Children's Hospital-Tampa

Tampa, Florida, 33607, United States
Saint Louis Cancer and Breast Institute-Ballwin

Ballwin, Missouri, 63011, United States
Saint Louis Cancer and Breast Institute-South City

St Louis, Missouri, 63109, United States
Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, 63670, United States
Sanford Bismarck Medical Center

Bismarck, North Dakota, 58501, United States
Sanford Joe Lueken Cancer Center

Bemidji, Minnesota, 56601, United States
Sanford Roger Maris Cancer Center

Fargo, North Dakota, 58122, United States
Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134, United States
Saskatoon Cancer Centre

Saskatoon, Saskatchewan, S7N 4H4, Canada
Southeast Cancer Center

Cape Girardeau, Missouri, 63703, United States
Southern Illinois University School of Medicine

Springfield, Illinois, 62702, United States
Southwest Illinois Health Services LLP

Swansea, Illinois, 62226, United States
Spectrum Health at Butterworth Campus

Grand Rapids, Michigan, 49503, United States
Springfield Clinic

Springfield, Illinois, 62702, United States
State University of New York Upstate Medical University

Syracuse, New York, 13210, United States
Stony Brook University Medical Center

Stony Brook, New York, 11794, United States
The Research Institute of the McGill University Health Centre (MUHC)

Montreal, Quebec, H3H 2R9, Canada
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States
Tom Baker Cancer Centre

Calgary, Alberta, T2N 4N2, Canada
Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, Michigan, 48154, United States
UC San Diego Moores Cancer Center

La Jolla, California, 92093, United States
UCHealth Memorial Hospital Central

Colorado Springs, Colorado, 80909, United States
UM Sylvester Comprehensive Cancer Center at Coral Gables

Coral Gables, Florida, 33146, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach

Deerfield Beach, Florida, 33442, United States
USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States
UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390, United States
UW Cancer Center at ProHealth Care

Waukesha, Wisconsin, 53188, United States
United Hospital

Saint Paul, Minnesota, 55102, United States
Unity Hospital

Fridley, Minnesota, 55432, United States
University Health Network-Princess Margaret Hospital

Toronto, Ontario, M5G 2M9, Canada
University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, 35233, United States
University of Arizona Cancer Center-North Campus

Tucson, Arizona, 85719, United States
University of Cincinnati Cancer Center-UC Medical Center

Cincinnati, Ohio, 45219, United States
University of Cincinnati Cancer Center-West Chester

West Chester, Ohio, 45069, United States
University of Colorado Hospital

Aurora, Colorado, 80045, United States
University of Iowa/Holden Comprehensive Cancer Center

Iowa City, Iowa, 52242, United States
University of Kansas Cancer Center

Kansas City, Kansas, 66160, United States
University of Kansas Cancer Center - Lee's Summit

Lee's Summit, Missouri, 64064, United States
University of Kansas Cancer Center at North Kansas City Hospital

North Kansas City, Missouri, 64116, United States
University of Kansas Cancer Center-Overland Park

Overland Park, Kansas, 66210, United States
University of Kansas Hospital-Indian Creek Campus

Overland Park, Kansas, 66211, United States
University of Kansas Hospital-Westwood Cancer Center

Westwood, Kansas, 66205, United States
University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136, United States
University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, 48109, United States
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
University of New Mexico Cancer Center

Albuquerque, New Mexico, 87102, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Rochester

Rochester, New York, 14642, United States
University of Virginia Cancer Center

Charlottesville, Virginia, 22908, United States
University of Wisconsin Carbone Cancer Center

Madison, Wisconsin, 53792, United States
Upstate Cancer Center Radiation Oncology at Oneida

Oneida, New York, 13421, United States
Valley Radiation Oncology

Peru, Illinois, 61354, United States
Virginia Commonwealth University/Massey Cancer Center

Richmond, Virginia, 23298, United States
Walter Knox Memorial Hospital

Emmett, Idaho, 83617, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Welch Cancer Center

Sheridan, Wyoming, 82801, United States
Western Illinois Cancer Treatment Center

Galesburg, Illinois, 61401, United States
Woman's Hospital

Baton Rouge, Louisiana, 70817, United States
Yale University

New Haven, Connecticut, 06520, United States

Conditions

Explore the condition pages connected to this study.

METASTATIC MALIGNANT NEOPLASM IN THE BRAIN