Brain tumor timing trial: does radiation before surgery work better?

NCT ID NCT05438212

Ongoing Disease control Sponsor: NRG Oncology Source: ClinicalTrials.gov ↗

Summary

This study compares two treatment schedules for patients with cancer that has spread to the brain. All patients receive surgery and a precise, high-dose radiation treatment called stereotactic radiosurgery (SRS). The trial is testing whether giving the radiation treatment before surgery is more effective at preventing the tumor from coming back and reducing side effects than the standard approach of giving radiation after surgery. Researchers are measuring tumor control, survival, symptoms, and thinking skills in 237 participants.

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Contacts and locations

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Locations

AMG Crystal Lake - Oncology

Crystal Lake, Illinois, 60014, United States
AMG Libertyville - Oncology

Libertyville, Illinois, 60048, United States
Advocate Christ Medical Center

Oak Lawn, Illinois, 60453-2699, United States
Advocate Good Samaritan Hospital

Downers Grove, Illinois, 60515, United States
Advocate Good Shepherd Hospital

Barrington, Illinois, 60010, United States
Advocate Lutheran General Hospital

Park Ridge, Illinois, 60068, United States
Advocate Outpatient Center - Aurora

Aurora, Illinois, 60506, United States
Advocate South Suburban Hospital

Hazel Crest, Illinois, 60429, United States
Ascension Saint Vincent Indianapolis Hospital

Indianapolis, Indiana, 46260, United States
Aspirus Cancer Care - James Beck Cancer Center

Rhinelander, Wisconsin, 54501, United States
Aspirus Cancer Care - Stevens Point

Stevens Point, Wisconsin, 54481, United States
Aspirus Cancer Care - Wisconsin Rapids

Wisconsin Rapids, Wisconsin, 54494, United States
Aspirus Regional Cancer Center

Wausau, Wisconsin, 54401, United States
Atrium Health Cabarrus/LCI-Concord

Concord, North Carolina, 28025, United States
Aurora BayCare Medical Center

Green Bay, Wisconsin, 54311, United States
Aurora Cancer Care-Grafton

Grafton, Wisconsin, 53024, United States
Aurora Cancer Care-Kenosha South

Kenosha, Wisconsin, 53142, United States
Aurora Cancer Care-Milwaukee

Milwaukee, Wisconsin, 53209, United States
Aurora Cancer Care-Milwaukee West

Wauwatosa, Wisconsin, 53226, United States
Aurora Cancer Care-Racine

Racine, Wisconsin, 53406, United States
Aurora Cancer Care-Southern Lakes VLCC

Burlington, Wisconsin, 53105, United States
Aurora Health Care Germantown Health Center

Germantown, Wisconsin, 53022, United States
Aurora Medical Center in Summit

Summit, Wisconsin, 53066, United States
Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin, 53215, United States
Aurora Sinai Medical Center

Milwaukee, Wisconsin, 53233, United States
Aurora West Allis Medical Center

West Allis, Wisconsin, 53227, United States
BJC Outpatient Center at Sunset Hills

Sunset Hills, Missouri, 63127, United States
Banner University Medical Center - Tucson

Tucson, Arizona, 85719, United States
Benefis Sletten Cancer Institute

Great Falls, Montana, 59405, United States
Billings Clinic Cancer Center

Billings, Montana, 59101, United States
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)

Québec, Quebec, G1R 2J6, Canada
CHUM - Centre Hospitalier de l'Universite de Montreal

Montreal, Quebec, H2X 3E4, Canada
CJW Medical Center - Johnston-Willis Campus

Richmond, Virginia, 23235, United States
California Pacific Medical Center-Pacific Campus

San Francisco, California, 94115, United States
Cancer Care Center of O'Fallon

O'Fallon, Illinois, 62269, United States
Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, 62526, United States
Capital Health Medical Center-Hopewell

Pennington, New Jersey, 08534, United States
Carilion Roanoke Memorial Hospital

Roanoke, Virginia, 24033, United States
Carle Cancer Center

Urbana, Illinois, 61801, United States
Carle Physician Group-Effingham

Effingham, Illinois, 62401, United States
Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, 61938, United States
Carle at The Riverfront

Danville, Illinois, 61832, United States
CaroMont Regional Medical Center

Gastonia, North Carolina, 28054, United States
Carolinas Medical Center/Levine Cancer Institute

Charlotte, North Carolina, 28203, United States
Case Western Reserve University

Cleveland, Ohio, 44106, United States
Castle Medical Center

Kailua, Hawaii, 96734, United States
Centralia Oncology Clinic

Centralia, Illinois, 62801, United States
Coborn Cancer Center at Saint Cloud Hospital

Saint Cloud, Minnesota, 56303, United States
Community Medical Center

Toms River, New Jersey, 08755, United States
Cooper Hospital University Medical Center

Camden, New Jersey, 08103, United States
Corewell Health Beaumont Troy Hospital

Troy, Michigan, 48085, United States
Corewell Health William Beaumont University Hospital

Royal Oak, Michigan, 48073, United States
Covenant Medical Center-Lakeside

Lubbock, Texas, 79410, United States
Crossroads Cancer Center

Effingham, Illinois, 62401, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, New Hampshire, 03756, United States
Decatur Memorial Hospital

Decatur, Illinois, 62526, United States
Delaware Health Center-Grady Cancer Center

Delaware, Ohio, 43015, United States
Duluth Clinic Ashland

Ashland, Wisconsin, 54806, United States
Edward Hospital/Cancer Center

Naperville, Illinois, 60540, United States
Elmhurst Memorial Hospital

Elmhurst, Illinois, 60126, United States
Emory Saint Joseph's Hospital

Atlanta, Georgia, 30342, United States
Emory University Hospital Midtown

Atlanta, Georgia, 30308, United States
Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322, United States
Essentia Health - Deer River Clinic

Deer River, Minnesota, 56636, United States
Essentia Health Cancer Center

Duluth, Minnesota, 55805, United States
Essentia Health Hibbing Clinic

Hibbing, Minnesota, 55746, United States
Essentia Health Saint Joseph's Medical Center

Brainerd, Minnesota, 56401, United States
Essentia Health Saint Mary's Hospital - Superior

Superior, Wisconsin, 54880, United States
Essentia Health Saint Mary's Medical Center

Duluth, Minnesota, 55805, United States
Essentia Health Sandstone

Sandstone, Minnesota, 55072, United States
Essentia Health Virginia Clinic

Virginia, Minnesota, 55792, United States
Essentia Health-Hayward Clinic

Hayward, Wisconsin, 54843, United States
Essentia Health-Spooner Clinic

Spooner, Wisconsin, 54801, United States
Gibbs Cancer Center-Gaffney

Gaffney, South Carolina, 29341, United States
Gibbs Cancer Center-Pelham

Greer, South Carolina, 29651, United States
Good Samaritan University Hospital

West Islip, New York, 11795, United States
Grady Health System

Atlanta, Georgia, 30303, United States
Grady Memorial Hospital

Delaware, Ohio, 43015, United States
Grant Medical Center

Columbus, Ohio, 43215, United States
Gunma University Hospital

Gunma, Maebashi, 371-8511, Japan
Hawaii Cancer Care - Westridge

‘Aiea, Hawaii, 96701, United States
Hawaii Cancer Care Inc - Waterfront Plaza

Honolulu, Hawaii, 96813, United States
Henrico Doctor's Hospital

Richmond, Virginia, 23229, United States
Hokkaido University Hospital

Sapporo, Hokkaido, 060-8648, Japan
Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112, United States
Indu and Raj Soin Medical Center

Beavercreek, Ohio, 45431, United States
Inova Schar Cancer Institute

Fairfax, Virginia, 22031, United States
Iowa Methodist Medical Center

Des Moines, Iowa, 50309, United States
Jersey City Medical Center

Jersey City, New Jersey, 07302, United States
Kaiser Permanente Los Angeles Medical Center

Los Angeles, California, 90027, United States
Kaiser Permanente-Anaheim

Anaheim, California, 92806, United States
Kaiser Permanente-Bellflower

Bellflower, California, 90706, United States
Kaiser Permanente-Ontario

Ontario, California, 91761, United States
Kapiolani Medical Center for Women and Children

Honolulu, Hawaii, 96826, United States
Kettering Medical Center

Kettering, Ohio, 45429, United States
Kyoto University Hospital

Kyoto, 606-8507, Japan
Lenox Hill Hospital

New York, New York, 10075, United States
Manhattan Eye Ear and Throat Hospital

New York, New York, 10065, United States
Mayo Clinic in Florida

Jacksonville, Florida, 32224-9980, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Memorial Medical Center

Modesto, California, 95355, United States
Mercy Health - Perrysburg Hospital

Perrysburg, Ohio, 43551, United States
Mercy Hospital Springfield

Springfield, Missouri, 65804, United States
Miami Cancer Institute

Miami, Florida, 33176, United States
Miller-Dwan Hospital

Duluth, Minnesota, 55805, United States
Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States
Missouri Baptist Sullivan Hospital

Sullivan, Missouri, 63080, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Moffitt Cancer Center - McKinley Campus

Tampa, Florida, 33612, United States
Moffitt Cancer Center at Wesley Chapel

Wesley Chapel, Florida, 33544, United States
Moffitt Cancer Center-International Plaza

Tampa, Florida, 33607, United States
Montefiore Medical Center - Moses Campus

The Bronx, New York, 10467, United States
Montefiore Medical Center-Einstein Campus

The Bronx, New York, 10461, United States
Montefiore Medical Center-Weiler Hospital

The Bronx, New York, 10461, United States
Mount Sinai Chelsea

New York, New York, 10011, United States
Mount Sinai Hospital

New York, New York, 10029, United States
Mount Sinai West

New York, New York, 10019, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, New York, 10032, United States
NYP/Weill Cornell Medical Center

New York, New York, 10065, United States
Nagoya University Hospital

Showa-Ku Nagoya, 466-0065, Japan
National Cancer Center Hospital

Tokyo, 104 0045, Japan
New York-Presbyterian/Brooklyn Methodist Hospital

Brooklyn, New York, 11215, United States
Newark Beth Israel Medical Center

Newark, New Jersey, 07112, United States
Northeast Radiation Oncology Center

Dunmore, Pennsylvania, 18512, United States
Northern Westchester Hospital

Mount Kisco, New York, 10549, United States
Northwest Wisconsin Cancer Center

Ashland, Wisconsin, 54806, United States
Northwestern Medicine Cancer Center Warrenville

Warrenville, Illinois, 60555, United States
Northwestern University

Chicago, Illinois, 60611, United States
Novant Health Cancer Institute Radiation Oncology - Wilmington

Wilmington, North Carolina, 28401, United States
Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States
Pali Momi Medical Center

‘Aiea, Hawaii, 96701, United States
Parkland Health Center - Farmington

Farmington, Missouri, 63640, United States
Penn State Milton S Hershey Medical Center

Hershey, Pennsylvania, 17033-0850, United States
Piedmont Hospital

Atlanta, Georgia, 30309, United States
Queen's Cancer Cenrer - POB I

Honolulu, Hawaii, 96813, United States
Queen's Cancer Center - Kuakini

Honolulu, Hawaii, 96817, United States
Queen's Medical Center

Honolulu, Hawaii, 96813, United States
Renown Regional Medical Center

Reno, Nevada, 89502, United States
Riverside Methodist Hospital

Columbus, Ohio, 43214, United States
Roswell Park Cancer Institute

Buffalo, New York, 14263, United States
Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903, United States
SMC Center for Hematology Oncology Union

Union, South Carolina, 29379, United States
Saint Barnabas Medical Center

Livingston, New Jersey, 07039, United States
Saint Joseph Hospital - Orange

Orange, California, 92868, United States
Saint Joseph's Hospital and Medical Center

Phoenix, Arizona, 85013, United States
Saint Luke's Hospital of Kansas City

Kansas City, Missouri, 64111, United States
Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, 63670, United States
Sanford Broadway Medical Center

Fargo, North Dakota, 58122, United States
Sanford Cancer Center Oncology Clinic

Sioux Falls, South Dakota, 57104, United States
Sanford Roger Maris Cancer Center

Fargo, North Dakota, 58122, United States
Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134, United States
Southern Illinois University School of Medicine

Springfield, Illinois, 62702, United States
Spartanburg Medical Center

Spartanburg, South Carolina, 29303, United States
Springfield Clinic

Springfield, Illinois, 62702, United States
Springfield Memorial Hospital

Springfield, Illinois, 62781, United States
Stanford Cancer Institute Palo Alto

Palo Alto, California, 94304, United States
State University of New York Upstate Medical University

Syracuse, New York, 13210, United States
Stony Brook University Medical Center

Stony Brook, New York, 11794, United States
Straub Clinic and Hospital

Honolulu, Hawaii, 96813, United States
Sutter Auburn Faith Hospital

Auburn, California, 95602, United States
Sutter Cancer Centers Radiation Oncology Services-Auburn

Auburn, California, 95603, United States
Sutter Cancer Centers Radiation Oncology Services-Roseville

Roseville, California, 95661, United States
Sutter Medical Center Sacramento

Sacramento, California, 95816, United States
Sutter Pacific Medical Foundation

Santa Rosa, California, 95403, United States
Sutter Roseville Medical Center

Roseville, California, 95661, United States
Sutter Solano Medical Center/Cancer Center

Vallejo, California, 94589, United States
Swedish Medical Center-Cherry Hill

Seattle, Washington, 98122-5711, United States
The Cancer Center of Hawaii-Liliha

Honolulu, Hawaii, 96817, United States
The Children's Hospital at TriStar Centennial

Nashville, Tennessee, 37203, United States
The New York Hospital Medical Center of Queens

Flushing, New York, 11355, United States
The Queen's Medical Center - West Oahu

‘Ewa Beach, Hawaii, 96706, United States
The Research Institute of the McGill University Health Centre (MUHC)

Montreal, Quebec, H3H 2R9, Canada
The Valley Hospital - Luckow Pavilion

Paramus, New Jersey, 07652, United States
ThedaCare Regional Cancer Center

Appleton, Wisconsin, 54911, United States
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States
UC Comprehensive Cancer Center at Silver Cross

New Lenox, Illinois, 60451, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, 92868, United States
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care

Irvine, California, 92612, United States
UCSF Medical Center-Parnassus

San Francisco, California, 94143, United States
UI Health Care Mission Cancer and Blood - Ankeny Clinic

Ankeny, Iowa, 50023, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic

Des Moines, Iowa, 50309, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic

Des Moines, Iowa, 50314, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic

Waukee, Iowa, 50263, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic

Clive, Iowa, 50325, United States
UM Baltimore Washington Medical Center/Tate Cancer Center

Glen Burnie, Maryland, 21061, United States
UM Capital Region Medical Center

Largo, Maryland, 20774, United States
UM Sylvester Comprehensive Cancer Center at Coral Gables

Coral Gables, Florida, 33146, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach

Deerfield Beach, Florida, 33442, United States
UM Sylvester Comprehensive Cancer Center at Doral

Doral, Florida, 33166, United States
UM Sylvester Comprehensive Cancer Center at Plantation

Plantation, Florida, 33324, United States
UM Upper Chesapeake Medical Center

Bel Air, Maryland, 21014, United States
UPMC-Presbyterian Hospital

Pittsburgh, Pennsylvania, 15213, United States
UPMC-Shadyside Hospital

Pittsburgh, Pennsylvania, 15232, United States
UW Cancer Center at ProHealth Care

Waukesha, Wisconsin, 53188, United States
University of Arizona Cancer Center-North Campus

Tucson, Arizona, 85719, United States
University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637, United States
University of Hawaii Cancer Center

Honolulu, Hawaii, 96813, United States
University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, 21201, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136, United States
University of Michigan Rogel Cancer Center

Ann Arbor, Michigan, 48109, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Rochester

Rochester, New York, 14642, United States
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center

Madison, Wisconsin, 53718, United States
University of Wisconsin Carbone Cancer Center - Johnson Creek

Johnson Creek, Wisconsin, 53038, United States
University of Wisconsin Carbone Cancer Center - University Hospital

Madison, Wisconsin, 53792, United States
VCU Massey Comprehensive Cancer Center

Richmond, Virginia, 23298, United States
Valley Health System Ridgewood Campus

Ridgewood, New Jersey, 07450, United States
Valley Health System-Hematology/Oncology

Westwood, New Jersey, 07675, United States
Vince Lombardi Cancer Clinic - Oshkosh

Oshkosh, Wisconsin, 54904, United States
Vince Lombardi Cancer Clinic-Sheboygan

Sheboygan, Wisconsin, 53081, United States
Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States
Weisberg Cancer Treatment Center

Farmington Hills, Michigan, 48334, United States
Wilcox Memorial Hospital and Kauai Medical Clinic

Lihue, Hawaii, 96766, United States

Conditions

Explore the condition pages connected to this study.

METASTATIC MALIGNANT NEOPLASM IN THE BRAIN