Brain scans probe how autistic minds handle the unexpected

NCT ID NCT06391684

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Cancelled before anyone took part.

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First seen Oct 02, 2026 · Last updated Oct 02, 2026

Summary

Researchers at University Hospital, Grenoble are comparing brain activity in autistic and non-autistic adults during tasks that require flexible thinking. Participants complete social and non-social tasks where cues are either predictable or unpredictable while undergoing fMRI scans. The study also explores whether autistic males and females show different brain patterns, since autistic women often present a subtler profile. The goal is to understand how the social nature and predictability of information shape cognitive flexibility at both the behavioral and brain level.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cognitive flexibility tasks with social and non-social predictable or unpredictable stimuli during fMRI
What this could lead to
If differences emerge, this could help explain why autistic people sometimes handle flexible thinking tasks differently, and whether social context or predictability changes that. It could also clarify whether autistic women show distinct brain patterns from autistic men.
What could go wrong
This is a small brain-imaging study of 40 people, so any patterns may not hold for the wider autistic community. fMRI measures blood flow as a proxy for brain activity, which limits how precisely researchers can link it to real-world thinking.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2025

Expected to finish

Apr 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Autistic with a diagnosis and non autistic adults.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: For non autistic individuals * Affiliation with social security scheme. * Registration in the national database of individuals willing to participate in research involving human subjects. * Absence of contraindications for MRI. * Signed informed consent before any study-related procedure. * Visual acuity allowing normal perception of stimuli or corrected vision. * Autism Quotient (AQ) (Baron-Cohen et al., 2001) \< 32. For autistic individuals: * Affiliation with social security scheme. * Absence of contraindications for MRI. * Signed informed consent before any study-related procedure. * Visual acuity allowing normal perception of stimuli or corrected vision. * Diagnosis of autism established by a competent professional based on DSM/ICD criteria. Exclusion Criteria: * Any subject with a vascular stent implanted less than 6 weeks before the examination. * Any subject with implanted biomedical material deemed "unsafe" or "not safe" in the list: http://www.mrisafety.com/TheList\_search.asp. * Any acquisition procedure not meeting the conditions required for "conditional" use in subjects with implanted biomedical material classified as "conditional" in the list: http://www.mrisafety.com/TheList\_search.asp. * Any subject with biomedical material such as a cardiac, neuronal, or sensory stimulator (cochlear implant due to the risk of demagnetization, heating, electrode, and artifacts) or a ventricular shunt valve without medical and paramedical supervision trained in MRI performance in these subjects. * Intraocular or intracranial ferromagnetic foreign body near nerve structures (risk of displacement and complications such as ocular or cerebral lesions). * Claustrophobia - Psychiatric or neurological conditions other than those specified. * Existence of a severe general health condition incompatible with the study: cardiac, respiratory, hematological, renal, hepatic, or cancerous. * Alcohol ingestion before the examination. * Persons covered by articles L1121-5 to L1121-8 of the Public Health Code (pregnant or breastfeeding women, minors or adults under legal protection, individuals under administrative or judicial surveillance). * Visual impairments. * Intellectual disability. * Inability to understand research instructions or provide informed consent.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

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  1. The places running it

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  2. The official record

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Contacts and locations

Locations

  • CHU Grenoble Alpes_DRCI_Pavillon Dauphiné_CS

    RECRUITING

    Grenoble, 38043, France

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