Brain scans probe how autistic minds handle the unexpected
NCT ID NCT06391684
First seen Oct 02, 2026 · Last updated Oct 02, 2026
Summary
Researchers at University Hospital, Grenoble are comparing brain activity in autistic and non-autistic adults during tasks that require flexible thinking. Participants complete social and non-social tasks where cues are either predictable or unpredictable while undergoing fMRI scans. The study also explores whether autistic males and females show different brain patterns, since autistic women often present a subtler profile. The goal is to understand how the social nature and predictability of information shape cognitive flexibility at both the behavioral and brain level.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- cognitive flexibility tasks with social and non-social predictable or unpredictable stimuli during fMRI
- What this could lead to
- If differences emerge, this could help explain why autistic people sometimes handle flexible thinking tasks differently, and whether social context or predictability changes that. It could also clarify whether autistic women show distinct brain patterns from autistic men.
- What could go wrong
- This is a small brain-imaging study of 40 people, so any patterns may not hold for the wider autistic community. fMRI measures blood flow as a proxy for brain activity, which limits how precisely researchers can link it to real-world thinking.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
About 40 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Feb 2025
- Expected to finish
-
Apr 2029
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Autistic with a diagnosis and non autistic adults.
- Ages
-
18 to 50 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: For non autistic individuals * Affiliation with social security scheme. * Registration in the national database of individuals willing to participate in research involving human subjects. * Absence of contraindications for MRI. * Signed informed consent before any study-related procedure. * Visual acuity allowing normal perception of stimuli or corrected vision. * Autism Quotient (AQ) (Baron-Cohen et al., 2001) \< 32. For autistic individuals: * Affiliation with social security scheme. * Absence of contraindications for MRI. * Signed informed consent before any study-related procedure. * Visual acuity allowing normal perception of stimuli or corrected vision. * Diagnosis of autism established by a competent professional based on DSM/ICD criteria. Exclusion Criteria: * Any subject with a vascular stent implanted less than 6 weeks before the examination. * Any subject with implanted biomedical material deemed "unsafe" or "not safe" in the list: http://www.mrisafety.com/TheList\_search.asp. * Any acquisition procedure not meeting the conditions required for "conditional" use in subjects with implanted biomedical material classified as "conditional" in the list: http://www.mrisafety.com/TheList\_search.asp. * Any subject with biomedical material such as a cardiac, neuronal, or sensory stimulator (cochlear implant due to the risk of demagnetization, heating, electrode, and artifacts) or a ventricular shunt valve without medical and paramedical supervision trained in MRI performance in these subjects. * Intraocular or intracranial ferromagnetic foreign body near nerve structures (risk of displacement and complications such as ocular or cerebral lesions). * Claustrophobia - Psychiatric or neurological conditions other than those specified. * Existence of a severe general health condition incompatible with the study: cardiac, respiratory, hematological, renal, hepatic, or cancerous. * Alcohol ingestion before the examination. * Persons covered by articles L1121-5 to L1121-8 of the Public Health Code (pregnant or breastfeeding women, minors or adults under legal protection, individuals under administrative or judicial surveillance). * Visual impairments. * Intellectual disability. * Inability to understand research instructions or provide informed consent.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Autism spectrum disorder are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
1 site. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
CHU Grenoble Alpes_DRCI_Pavillon Dauphiné_CS
RECRUITINGGrenoble, 38043, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Pai.ACT: an artificial Intelligence-Driven Chatbot-Assisted ACT mobile platform with mental health triage - a randomized controlled trial and regional service evaluation
- Resilience in action: building resilience and appropriate independence in young adults with autism
- Second look at DNA may crack unsolved cases of childhood brain disorders
- Three good things a day: can journaling lighten the load for autism moms?
- Parent-Led nutrition lessons put to the test for picky eating in autism
- Can a Heart-Rate app help teachers calm autism meltdowns before they start?