Brain scans reveal why some depressed patients Can't shake negative thoughts
NCT ID NCT05577247
First seen Apr 14, 2026 · Last updated May 15, 2026 · Updated 4 times
Summary
This study looks at how the brain handles negative beliefs in people with treatment-resistant depression. Researchers will use brain scans (fMRI) to see how beliefs change before and after a single dose of ketamine. The goal is to understand why some depressed patients hold onto negative thoughts even when faced with positive information, and how ketamine might help. The study involves 60 adults aged 18-70 with major depression that hasn't improved with at least two prior treatments.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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GH Pitié Salpêtrière
RECRUITINGParis, France
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