Nature's wrinkle fighter? botanical extract put to the test
NCT ID NCT07780799
First seen Aug 24, 2026 · Last updated Aug 25, 2026 · Updated 1 time
Summary
This trial tests whether a botanical extract added to a simple skincare formula can improve signs of aging, such as wrinkles, skin tone, and elasticity. It involves 66 women aged 35 to 60 with dry skin, who apply the product or a placebo to different sides of their face for 8 weeks. Researchers measure changes in skin using specialized instruments and dermatologist assessments. The goal is to see if the extract offers real anti-ageing benefits beyond the base formula.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- A topical skincare formulation containing a botanical extract at two concentrations (0.05% and 0.14%), applied twice daily for 56 days.
- What this could lead to
- If effective, this botanical extract could become a natural ingredient in anti-ageing skincare products, offering a gentle way to reduce wrinkles and improve skin firmness.
- What could go wrong
- This is a small, early-stage cosmetic study, so results may not apply to all skin types or guarantee long-term benefits. The extract's effects are limited to topical use and may be modest.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
66 people
The number who actually took part.
- Started
-
Oct 2025
- Expected to finish
-
Sep 2026
An estimate. End dates often move.
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
35 to 60 years
- Sex
-
Female participants only
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Chinese female subjects aged 35 to 60 years (inclusive) in good general health based on subjective self-report and investigator assessment. 2. Fitzpatrick skin type II, III, or IV. 3. Self-reported dry skin type. 4. Meets specified skin criteria assessed by investigator: Crow's feet wrinkle grade between 3 and 5 (inclusive), with priority given to subjects with a side-to-side difference ≤ 0.5 in grade. 5. Facial trans-epidermal water loss (TEWL) ≥ 6 g/m²·h as measured by Vapometer. 6. Facial stratum corneum hydration level between 20 and 45 (inclusive) as measured by Corneometer. 7. Willing to avoid excessive sun exposure throughout the study period. 8. Females of childbearing potential (FCBP) must agree to use highly effective contraception methods or remain abstinent from 1 month prior to study start through study completion; or postmenopausal females. 9. FCBP must have a negative urine pregnancy test at screening. 10. Willing to undergo tape-stripping procedures for stratum corneum sampling. 11. No other dermatological conditions deemed unsuitable for participation (e.g., facial tattoos, scars). 12. Willing to sign Informed Consent Form (ICF) and Image Authorization Form. 13. Able and willing to comply with all study procedures and visit schedules. Exclusion Criteria: 1. Current pregnancy, breastfeeding, or planning to become pregnant. 2. Current smokers or history of smoking within the last 6 months (including e-cigarettes/nicotine products). 3. History of facial cosmetic procedures (fillers, lasers, implants, Botox, etc.). 4. Active systemic or localized skin diseases (acne, eczema, psoriasis, atopic dermatitis). 5. Known allergies to cosmetics, personal care products, or their ingredients. 6. Excessive UV exposure or frequent sauna/water sports usage. 7. Use of antihistamines, antibiotics, corticosteroids, or NSAIDs within relevant washout periods. 8. Participation in any other clinical trial within the past 30 days. 9. Planned surgical or invasive procedures during the study period. 10. Individuals deprived of liberty by judicial or administrative order. 11. Subjects who cannot be reached by telephone in case of an emergency. 12. Any other condition that, in the investigator's opinion, makes the subject unsuitable for participation.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Aging are added.
By submitting, you agree to our Terms of use
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
L'OREAL R&I China
Shanghai, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Skeletal muscle myosin binding protein c in fatigue and aging
- Longevity metrics AI/ML development study: a standing data library and Model-Development platform for predicting and validating health measurements, longevity, and disease
- Can Weight-Loss surgery weaken protein digestion in older adults?
- A plastic shell on the chest may help older adults with obesity breathe easier
- Protein plus exercise: a recipe to rebuild muscle while losing fat in older age?
- Zapping the brain to shift Decision-Making in depression and aging