New hope for myeloma patients too old for transplant?

NCT ID NCT05272826

Recruiting now Disease control Sponsor: Canadian Myeloma Research Group Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a combination of four drugs—iberdomide, bortezomib, dexamethasone, and isatuximab—for people newly diagnosed with multiple myeloma who are not eligible for a stem cell transplant. The goal is to see if this treatment can shrink or eliminate the cancer. About 75 participants aged 65 and older will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: iberdomide, bortezomib, dexamethasone, and isatuximab
What this could lead to: If successful, this could offer a new, effective treatment option for older adults with multiple myeloma who cannot undergo a stem cell transplant.
What could go wrong: This is a small, early-phase (Phase 2) trial with only 75 participants, so results may not apply to everyone. The drug combination may cause side effects or not work as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA

Contacts and locations

Locations

Cross Cancer Institute
RECRUITING

Edmonton, Alberta, T6G 1Z2, Canada
Hôpital Maisonneuve-Rosemont
RECRUITING

Montreal, Quebec, Canada
London Health Sciences Centre
RECRUITING

London, Ontario, Canada
McGill University Health Centre
RECRUITING

Montreal, Quebec, Canada
NL Health Services
RECRUITING

St. John's, Newfoundland and Labrador, A1B 3V6, Canada
Princess Margaret Hospital
RECRUITING

Toronto, Ontario, Canada
QEII Health Science Centre
RECRUITING

Halifax, Nova Scotia, Canada

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