Testosterone therapy reshapes bodies of transgender men, study finds

NCT ID NCT07481942

Completed Knowledge-focused Sponsor: Celia Bañuls Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how one year of testosterone therapy changes body composition in 70 transgender men. Researchers used bioelectrical impedance and muscle ultrasound to track muscle gain and fat redistribution. The goal is to find better ways to monitor these changes and understand differences between testosterone types.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: testosterone (gender-affirming hormone therapy)
What this could lead to: If successful, this could help doctors better monitor muscle and fat changes in transgender men on hormone therapy, improving personalized care.
What could go wrong: This is a small, completed observational study with 70 participants. Results may not apply to all transgender men, and the methods (BIVA, ultrasound) need further validation.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TRANSGENDER

Contacts and locations

Locations

FISABIO

Valencia, Valencia, 46020, Spain

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