New hope for aggressive lung cancer: phase 3 trial launches

NCT ID NCT06712355

Recruiting now Disease control Sponsor: BioNTech SE Source: ClinicalTrials.gov ↗

First seen Dec 04, 2025 · Last updated Jun 15, 2026 · Updated 31 times

Summary

This study tests whether a new drug called BNT327, combined with standard chemotherapy, helps people with advanced small-cell lung cancer live longer compared to another approved drug (atezolizumab) plus the same chemo. About 621 adults who have not yet been treated for their cancer will take part. The goal is to see if the new combination improves survival and slows tumor growth.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

ACRC Arizona Clinical Research Center
RECRUITING

Tucson, Arizona, 85715, United States
Acibadem Adana Hospital
RECRUITING

Adana, 1130, Turkey (Türkiye)
Addenbrooke's Hospital - Cambridge University Hospitals NHS Foundation Trust
RECRUITING

Cambridge, CB2 0QQ, United Kingdom
Affiliated Hospital of Hebei University
ACTIVE_NOT_RECRUITING

Baoding, 071105, China
Ajou University Hospital
RECRUITING

Suwon, Gyeonggi-do, 16499, South Korea
Akdeniz University Hospital
RECRUITING

Antalya, Turkey (Türkiye)
Anhui Provincial Hospital
ACTIVE_NOT_RECRUITING

Hefei, 230001, China
Ankara Bilkent City Hospital
RECRUITING

Ankara, 6800, Turkey (Türkiye)
Ankara Etlik City Hospital
RECRUITING

Ankara, 06170, Turkey (Türkiye)
Ankara University Medical Faculty Hospital
RECRUITING

Mamak, 06220, Turkey (Türkiye)
Asan Medical Center (AMC)
RECRUITING

Seoul, 5505, South Korea
Asklepios Fachkliniken Muenchen Gauting
RECRUITING

Gauting, 82131, Germany
Azienda Ospedaliera San Giuseppe Moscati
RECRUITING

Avellino, 83100, Italy
Azienda Socio Sanitaria Territoriale di Cremona
RECRUITING

Cremona, 26100, Italy
Baptist Cancer Center
RECRUITING

Southaven, Mississippi, 38671, United States
Baptist Health Hardin Cancer Center
RECRUITING

Elizabethtown, Kentucky, 42701, United States
Baskent University Adana Turgut Noyan Application and Research Center
RECRUITING

Adana, 1250, Turkey (Türkiye)
Beijing Chest Hospital,Capital Medical University
ACTIVE_NOT_RECRUITING

Beijing, 101149, China
Beijing Friendship Hospital, Capital Medical University
ACTIVE_NOT_RECRUITING

Beijing, 100050, China
Beth Israel Lahey Health - Lahey Hospital & Medical Center (LHMC), Lahey Clinic Medical Center
RECRUITING

Burlington, Massachusetts, 01805, United States
CHU de Caen
RECRUITING

Caen, 14033, France
CHU de Rennes, Hopital de Pontchaillou
RECRUITING

Rennes, 35033, France
Cairns Hospital
RECRUITING

Cairns, Queensland, 4870, Australia
Cairns Hospital
RECRUITING

Cairns, 4870, Australia
Calvary Mater Newcastle
RECRUITING

Waratah, New South Wales, 2298, Australia
Cancer Care Centers of Brevard, Inc
RECRUITING

Palm Bay, Florida, 32901, United States
Cancer Care Wollongong Pty Limited
RECRUITING

Wollongong, New South Wales, 2500, Australia
Cancer Hospital Chinese Academy of Medical Sciences
ACTIVE_NOT_RECRUITING

Hebei, 065001, China
Cancer Hospital of Shantou University Medical College
WITHDRAWN

Shantou, 515041, China
Casa Di Cura Polispecialistica Dott Pederzoli
RECRUITING

Peschiera del Garda, 37019, Italy
Centre Hospitalier Intercommunal Toulon La Seyne Sur Mer (C.H.I.T.S) - Hopital Sainte Musse
RECRUITING

Toulon, 83056, France
Centre Hospitalier Universitaire d'Angers (CHU Angers)
RECRUITING

Angers, 49933, France
Centro di Riferimento Oncologico
RECRUITING

Aviano, 33081, Italy
Centrul de Oncologie Euroclinic srl
RECRUITING

Iași, 700106, Romania
Centrul de Oncologie Sf. Nectarie S.R.L (Sf Nectarie Oncology Center)
RECRUITING

Craiova, 200542, Romania
Charite - Universitaetsmedizin Berlin - Campus Virchow-Klinikum (CVK)
RECRUITING

Berlin, 13353, Germany
Chongqing University Three Gorges Hospital
ACTIVE_NOT_RECRUITING

Wanzhou, 404000, China
Chungbuk National University Hospital
RECRUITING

Cheongju-si, 28644, South Korea
Churchill Hospital - Oxford University Hospitals NHS Foundation Trust
RECRUITING

Oxford, Oxfordshire, OX3 7LE, United Kingdom
City Hospital Onesti
RECRUITING

Onești, 601048, Romania
Clermont Oncology Center
TERMINATED

Clermont, Florida, 34711, United States
Cleveland Clinic - Akron General Hematology & Oncology
RECRUITING

Akron, Ohio, 44302, United States
Cleveland Clinic - Hillcrest Hospital
RECRUITING

Mayfield Heights, Ohio, 44124, United States
Cleveland Clinic Foundation
RECRUITING

Cleveland, Ohio, 44195-0001, United States
Cleveland Clinic Mercy Hospital Cancer Center
RECRUITING

Canton, Ohio, 44708, United States
Clinica MD Anderson International
RECRUITING

Madrid, 28033, Spain
Coltea Clinical Hospital
RECRUITING

Bucharest, 030171, Romania
Consorcio Hospitalario Provincial de Castellon
RECRUITING

Castellon, 12002, Spain
Cornell University - NewYork-Presbyterian/Weill Cornell Medical Center
RECRUITING

New York, New York, 10065, United States
Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
RECRUITING

Ankara, 6200, Turkey (Türkiye)
Evangelische Lungenklinik Berlin
RECRUITING

Berlin, 13125, Germany
Fort Wayne Medical Oncology and Hematology, Inc
RECRUITING

Fort Wayne, Indiana, 46804, United States
Frederick Health Hospital- James M Stockman Cancer Institute
RECRUITING

Frederick, Maryland, 21704, United States
Fudan University - Shanghai Cancer Center (FUSCC)
ACTIVE_NOT_RECRUITING

Shanghai, 200032, China
Fujian Provincial Cancer Hospital
ACTIVE_NOT_RECRUITING

Fuzhou, 350014, China
FutureMeds Krakow
RECRUITING

Krakow, 31-501, Poland
Gachon University Gil Medical Center
RECRUITING

Incheon, Namdong-gu, 21565, South Korea
Gazi University, Medical Faculty Hospital
RECRUITING

Ankara, 6560, Turkey (Türkiye)
Goztepe Prof. Dr. Suleyman Yalcin City Hospital
RECRUITING

Istanbul, 41380, Turkey (Türkiye)
Guangdong General Hospital
ACTIVE_NOT_RECRUITING

Guangzhou, 510080, China
Guangxi Tumour Hospital
ACTIVE_NOT_RECRUITING

Nanning, 530000, China
Gulhane Training and Research Hospital
RECRUITING

Ankara, 6010, Turkey (Türkiye)
Guy's Hospital - Guy's & St Thomas' NHS Foundation Trust
RECRUITING

London, SE1 9RT, United Kingdom
Gyeongsang National University Hospital (GNUH)
RECRUITING

Jinju, Gyeongsangnam-do, 52727, South Korea
Hacettepe University Medical Faculty Hospital
RECRUITING

Ankara, 6230, Turkey (Türkiye)
Harbin Medical University Cancer Hospital
WITHDRAWN

Ha’erbin, 150040, China
Helen G. Nassif Community Cancer Center
RECRUITING

Cedar Rapids, Iowa, 52403, United States
Helios Klinikum Wuppertal-Universitaet Witten-Herdecke
RECRUITING

Wuppertal, 42283, Germany
Hematology Oncology Associates of Fredericksburg, Inc.
RECRUITING

Fredericksburg, Virginia, 22408, United States
Henan Cancer Hospital (Affiliated Cancer Hospital of Zhengzhou University)
ACTIVE_NOT_RECRUITING

Zhengzhou, 450008, China
Hospital Alvaro Cunqueiro
RECRUITING

Vigo, 36312, Spain
Hospital Clinico Universitario Lozano Blesa de Zaragoza
RECRUITING

Zaragoza, 50009, Spain
Hospital General Universitario Gregorio Maranon (HGUGM)
RECRUITING

Madrid, 28007, Spain
Hospital Regional Universitario de Malaga
RECRUITING

Málaga, 29010, Spain
Hospital Universitario Nuestra Senora De Valme
RECRUITING

Seville, 41014, Spain
Hospital Universitario Vall d'Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario de Badajoz
RECRUITING

Badajoz, 06006, Spain
Huddersfield Royal Infirmary - Calderdale and Huddersfield NHS Foundation Trust
RECRUITING

Huddersfield, North Yorkshire, HD3 3EA, United Kingdom
Hull University Teaching Hospitals NHS Trust
RECRUITING

Cottingham, HU16 5JQ, United Kingdom
IRCCS Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" (IRST)
RECRUITING

Meldola, 47014, Italy
Icon Cancer Centre Kurralta Park
RECRUITING

Kurralta Park, South Australia, 5037, Australia
Illinois Cancer Specialists
RECRUITING

Niles, Illinois, 60714, United States
Institut Bergonie - Centre Regional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest
RECRUITING

Bordeaux, 33076, France
Institut Curie - Centre de Recherche
RECRUITING

Paris, 75005, France
Institut de Cancerologie de l'Ouest (ICO)- CRLCC Rene Gauducheau
RECRUITING

Saint-Herblain, 44805, France
Jiamusi Cancer Hospital
ACTIVE_NOT_RECRUITING

Jiamusi, 154007, China
Jiangsu Peoples Hospital
ACTIVE_NOT_RECRUITING

Nanjing, 210029, China
Jilin Cancer Hospital
ACTIVE_NOT_RECRUITING

Changchun, Jilin, 130012, China
KOMED Roman Karaszewski I Wspolnicy Spolka Jawna
RECRUITING

Konin, 62-500, Poland
Kanagawa Cancer Center
RECRUITING

Yokohama, 241-8515, Japan
Kettering Medical Center
RECRUITING

Kettering, Ohio, 45429, United States
Klinikum Chemnitz Gmbh
RECRUITING

Chemnitz, 09116, Germany
Klinikum Esslingen GmbH
RECRUITING

Esslingen am Neckar, 73730, Germany
Klinikum Kempten-Oberallgau gGmbH
RECRUITING

Kempten, 87439, Germany
Klinikum Nuernberg Nord
RECRUITING

Nuremberg, 90419, Germany
Koc Universitesi Hastanesi (Koc University Hospital)
RECRUITING

Istanbul, 34010, Turkey (Türkiye)
Kocaeli University Medical Faculty Hospital
RECRUITING

Kocaeli, 41380, Turkey (Türkiye)
Korea University Guro Hospital
RECRUITING

Seoul, Guro-gu, 8308, South Korea
Krankenhaus Martha-Maria Halle-Doelau gGmbH
RECRUITING

Halle, 06120, Germany
Kurume University Hospital
RECRUITING

Kurume, 830-0011, Japan
Linyi Cancer Hospital
ACTIVE_NOT_RECRUITING

Linyi, 276034, China
Liv Hospital Ankara
RECRUITING

Ankara, 6680, Turkey (Türkiye)
LungenClinic Grosshansdorf GmbH
RECRUITING

Großhansdorf, 22927, Germany
MVZ for oncology and hematology Rhein-Kreis Neuss GmbH
RECRUITING

Neuss, 41462, Germany
Marmara University Pendik Training and Research Hospital
RECRUITING

Istanbul, 34899, Turkey (Türkiye)
Matsusaka Municipal Hospital
RECRUITING

Matsusaka, 515-8544, Japan
McFarland Clinic
RECRUITING

Ames, Iowa, 50010, United States
Medical Park Florya Hospital
RECRUITING

Istanbul, 34295, Turkey (Türkiye)
Medical Point Izmir Hospital
RECRUITING

Izmir, 35575, Turkey (Türkiye)
Memorial Ankara Hospital
RECRUITING

Ankara, 6520, Turkey (Türkiye)
Millennium Research and Clinical Development, LLC
TERMINATED

Houston, Texas, 77090, United States
NHO Kinki Chuo Chest Medical Center
RECRUITING

Sakai, 591-8555, Japan
National Cancer Center
RECRUITING

Goyang-si, Gyeonggi-do, 10408, South Korea
National Cancer Center Hospital
RECRUITING

Chūōku, 104-0045, Japan
National Hospital Organization Himeji Medical Center
RECRUITING

Himeji, 670-8520, Japan
National Hospital Organization Iwakuni Clinical Center
RECRUITING

Iwakuni, 740-8510, Japan
National Hospital Organization Kyushu Cancer Center
RECRUITING

Fukuoka, 811-1395, Japan
National Hospital Organization Nagoya Medical Center
RECRUITING

Nagoya, 460-0001, Japan
National Hospital Organization Shikoku Cancer Center
RECRUITING

Matsuyama, 791-0280, Japan
National Hospital Organization Yamaguchi-Ube Medical Center
RECRUITING

Ube, 755-0241, Japan
Nebraska Hematology-Oncology (NHO)
RECRUITING

Lincoln, Nebraska, 68506, United States
New Cross Hospital
RECRUITING

Wolverhampton, West Midlands, WV10 0QP, United Kingdom
Niigata Cancer Center Hospital
RECRUITING

Niigata, 951-8566, Japan
Ninewells Hospital and Medical School - Tayside Health Board
RECRUITING

Dundee, Scotland, DD1 9SY, United Kingdom
Northern Centre for Cancer Care - The Newcastle Upon Tyne Hospitals NHS Foundation Trust
RECRUITING

Newcastle upon Tyne, Northumberland, NE7 7DN, United Kingdom
Northern Jiangsu Peoples Hospital (NJPH)
WITHDRAWN

Yangzhou, 225001, China
Nottingham University Hospitals NHS Trust - Nottingham City Hospital
RECRUITING

Nottingham, Nottinghamshire, NG5 1PB, United Kingdom
Okayama University Hospital
RECRUITING

Okayama, 700-8558, Japan
Olivia Newton-John Cancer Wellness & Research centre
RECRUITING

Heidelberg, Victoria, 3084, Australia
Oncocenter Oncologie Clinica S.R.L
RECRUITING

Timișoara, 300166, Romania
Osaka Prefectural Hospital Organization Osaka International Cancer Institute
RECRUITING

Osaka, 541-8567, Japan
Ospedale San Luca
RECRUITING

Lucca, 55100, Italy
Parc de Salut Mar - Hospital del Mar
RECRUITING

Barcelona, 08003, Spain
Peking Union Medical College Hospital
WITHDRAWN

Beijing, 100730, China
Peninsula & South Eastern Haematology and Oncology Group
RECRUITING

Frankston, Victoria, 3199, Australia
Pratia Onkologia Katowice
RECRUITING

Katowice, 40-519, Poland
Pratia S.A. , Pratia Poznan
RECRUITING

Poznan, 60192, Poland
Pratia Wroclaw Onkologia
RECRUITING

Wroclaw, 50-019, Poland
Praxiskooperation Bonn-Euskirchen-Rheinbach-Wesseling
RECRUITING

Bonn, 53123, Germany
Royal Devon and Exeter Hospital, Royal Devon University Healthcare NHS Foundation Trust
RECRUITING

Exeter, EX2 5DW, United Kingdom
Royal Marsden Hospital (RMH) - Royal Marsden NHS Foundation Trust
RECRUITING

Chelsea, London, SW3 6JJ, United Kingdom
Royal Marsden Hospital (Sutton) - Royal Marsden NHS Foundation Trust
RECRUITING

Sutton, London, SM2 5PT, United Kingdom
Royal North Shore Hospital
RECRUITING

Saint Leonards, 2065, Australia
Royal Preston Hospital - Lancashire Teaching Hospitals NHS Foundation Trust
RECRUITING

Preston, PR2 9HT, United Kingdom
Royal Stoke University Hospital - University Hospitals of North Midlands NHS Trust
RECRUITING

Stoke-on-Trent, Staffordshire, ST4 6QG, United Kingdom
SC Oncopremium Team SRL
RECRUITING

Baia Mare, 430291, Romania
SRH Wald-Kliniken Gera GmbH
RECRUITING

Gera, 07548, Germany
Sakarya University Training and Research Hospital
RECRUITING

Sakarya, 54290, Turkey (Türkiye)
Samsung Medical Center
RECRUITING

Seoul, 6351, South Korea
Sendai Kousei Hospital
RECRUITING

Miyagi, 981-0914, Japan
Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, 3722, South Korea
Seyhan Medical Park Hospital
RECRUITING

Adana, 1140, Turkey (Türkiye)
Shandong Cancer Hospital and Institute
ACTIVE_NOT_RECRUITING

Jinan, 250117, China
Shandong University - Jinan Central Hospital
ACTIVE_NOT_RECRUITING

Jinan, 250013, China
Shanghai Chest Hospital
ACTIVE_NOT_RECRUITING

Shanghai, 200030, China
Shanxi Provincial Tumor Hospital (Shanxi Oncology Hospital)
ACTIVE_NOT_RECRUITING

Taiyuan, 030013, China
Shenandoah Oncology
RECRUITING

Winchester, Virginia, 22601, United States
Shibukawa Medical Center
RECRUITING

Shibukawa, 377-0280, Japan
St James's University Hospital - Leeds Teaching Hospitals NHS Trust
RECRUITING

Leeds, LS9 7TF, United Kingdom
St. Luke's Physician Group - St. Luke's Cancer Care Associates
RECRUITING

Fountain Hill, Pennsylvania, 18015-1153, United States
Staedtisches Klinikum Muenchen Bogenhausen
RECRUITING

München, 81925, Germany
Taizhou Hospital of Zhejiang Province
ACTIVE_NOT_RECRUITING

Zhejiang, 317000, China
Texas Oncology Cancer Center
RECRUITING

Sugar Land, Texas, 77479, United States
The Catholic University Of Korea, St. Vincent's Hospital
RECRUITING

Suwon, Gyeonggi-do, 16247, South Korea
The Christ Hospital Cancer Center
RECRUITING

Cincinnati, Ohio, 45219, United States
The Christie NHS Foundation Trust
RECRUITING

Manchester, Lancashire, M20 4BX, United Kingdom
The Cleveland Clinic Cancer Center at Fairview Hospital, Moll Pavilion
RECRUITING

Cleveland, Ohio, 44111, United States
The First Affiliated Hospital Of Wenzhou Medical University
WITHDRAWN

Wenzhou, 325000, China
The First Affiliated Hospital of Bengbu Medical College
ACTIVE_NOT_RECRUITING

Bengbu, 233004, China
The First Affiliated Hospital of Henan Medical University
ACTIVE_NOT_RECRUITING

Xinxiang, 453100, China
The First Affiliated Hospital of Nanchang University
ACTIVE_NOT_RECRUITING

Nanchang, 330006, China
The First Affiliated Hospital of Soochow University
ACTIVE_NOT_RECRUITING

Suzhou, 215006, China
The Queen Elizabeth Hospital
RECRUITING

Woodville, South Australia, 5011, Australia
The University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Tokyo Metropolitan Komagome Hospital
RECRUITING

Bunkyō City, 113-8677, Japan
Torbay and South Devon NHS Foundation Trust
RECRUITING

Torquay, South Devon, TQ2 7AA, United Kingdom
Trakya University Faculty of Medicine
RECRUITING

Edirne, 22030, Turkey (Türkiye)
UOMI Cancer Center-Clinica Tres Torres
RECRUITING

Barcelona, 08017, Spain
Union Hospital Tongji Medical College of Huazhong University of Science and Technology (HUST)
ACTIVE_NOT_RECRUITING

Wuhan, 430022, China
Universidad de Sevilla - Hospital Universitario Virgen Macarena
RECRUITING

Seville, 41009, Spain
Universita Degli Studi Di Milano-Bicocca - Azienda Ospedaliera San Gerardo Di Monza
RECRUITING

Monza, 20900, Italy
Universitaetsklinikum Schleswig-Holstein (UKSH) - Campus Luebeck
RECRUITING

Lübeck, 23538, Germany
Universitat de Valencia - Hospital Universitari i Politecnic La Fe de Valencia (Hospital La Fe Bulevar Sur)
RECRUITING

Valencia, 46026, Spain
University Hospitals Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States
University Medical Center of Johannes Gutenberg-University Mainz
RECRUITING

Mainz, 55131, Germany
University of Tennessee Medical Center
RECRUITING

Knoxville, Tennessee, 37920, United States
Uniwersytecki Szpital Kliniczny Nr 4 w Lublinie
RECRUITING

Lublin, 20-090, Poland
Uniwersyteckie Centrum Kliniczne
RECRUITING

Gdansk, 80-214, Poland
Velindre NHS Trust, Velindre Cancer Centre
RECRUITING

Cardiff, Wales, CF14 2TL, United Kingdom
Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States
Virginia Commonwealth University School of Medicine
RECRUITING

Richmond, Virginia, 23298, United States
Warminsko Mazurskie Centrum Chorob Pluc w Olsztynie
RECRUITING

Olsztyn, 10-357, Poland
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States
Western Health Sunshine Hospital
RECRUITING

St Albans, Victoria, 3021, Australia
White Plains Hospital
RECRUITING

White Plains, New York, 10601, United States
Wielkopolskie Centrum Pulmonologii i Tarakochirurgii
RECRUITING

Poznan, 60-569, Poland
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu
RECRUITING

Przemyśl, 37-700, Poland
Xiangyang Central Hospital
ACTIVE_NOT_RECRUITING

Xiangyang, 441000, China
Yeditepe University Kosuyolu Hospital
RECRUITING

Istanbul, 34718, Turkey (Türkiye)
Yunnan Provincial Cancer Hospital
ACTIVE_NOT_RECRUITING

Kunming, 650000, China
Zhejiang Medical University, Zhejiang Cancer Hospital
ACTIVE_NOT_RECRUITING

Hangzhou, 310022, China
Zhongnan Hospital of Wuhan University
ACTIVE_NOT_RECRUITING

Wuhan, 430071, China

Conditions

Explore the condition pages connected to this study.

EXTENSIVE-STAGE SMALL CELL LUNG CANCER EXTENSIVE-STAGE SMALL-CELL LUNG CANCER