New cancer combo shows promise in early trial

NCT ID NCT04710043

First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 21 times

Summary

This early-stage trial tested two experimental drugs, BNT152 and BNT153, in 86 adults with advanced solid tumors that had spread or could not be removed and had no standard treatment options. The main goal was to check safety and find the best dose. Researchers also looked for signs that the drugs were working against the tumors.

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Contacts and locations

Locations

  • Duke Cancer Center

    Durham, North Carolina, 27710, United States

  • MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Masaryk Memorial Cancer Institute

    Brno, 65653, Czechia

  • NEXT Oncology

    San Antonio, Texas, 78229, United States

  • Robert H. Lurie Comprehensive Cancer Center, Northwestern University

    Chicago, Illinois, 60611, United States

  • Sarah Cannon Research Institute at Tennessee Oncology

    Nashville, Tennessee, 37203, United States

  • Yale Cancer Center

    New Haven, Connecticut, 06520, United States

Conditions

Explore the condition pages connected to this study.