Donor immune cells aim to tame autoimmune attacks

NCT ID NCT07115745

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study tests a new treatment made from healthy donor immune cells (CAR T cells) for people with severe autoimmune diseases like lupus that haven't responded to standard therapies. The goal is to see if these cells can safely target and calm the overactive immune system. About 125 participants will receive the treatment and be monitored for side effects and effectiveness.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

autoimmune disease connective tissue disorder dermatomyositis diffuse scleroderma inclusion body myositis lupus nephritis musculoskeletal system disorder myositis disease polymyositis rheumatoid arthritis Sclerosis skin disorder systemic lupus erythematosus systemic sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

Locations

  • ARENSIA Exploratory Medicine

    RECRUITING

    Cluj-Napoca, Cluj, 400015, Romania

    Contact Phone: •••-•••-••••

  • Brigham And Womens Hospital

    RECRUITING

    Boston, Massachusetts, 02115, United States

    Contact Phone: •••-•••-••••

  • CHU Strasbourg-Hautepierre

    RECRUITING

    Strasbourg, Alsace, 67098, France

    Contact Phone: •••-•••-••••

  • Charité - Universitaetsmedizin Berlin - Campus Bejnamin Franklin

    RECRUITING

    Berlin, 10117, Germany

    Contact Phone: •••-•••-••••

  • Duke University

    RECRUITING

    Durham, North Carolina, 27705-2771, United States

    Contact Phone: •••-•••-••••

  • Fundeni Clinical Institute

    RECRUITING

    Bucharest, 022328, Romania

    Contact Phone: •••-•••-••••

  • Hadassah Medical Center

    RECRUITING

    Jerusalem, 9112001, Israel

    Contact Phone: •••-•••-••••

  • Hopital Claude Huriez - CHU de Lille

    RECRUITING

    Lille, Nord, 59037, France

    Contact Phone: •••-•••-••••

  • Hospital Universitari Vall d'Hebron

    RECRUITING

    Barcelona, Barcelona [Barcelona], 08035, Spain

    Contact Phone: •••-•••-••••

  • Hospital Universitario Ramón y Cajal

    RECRUITING

    Madrid, Madrid, Comunidad de, 28034, Spain

    Contact Phone: •••-•••-••••

  • Hospital de la Santa Creu i Sant Pau

    RECRUITING

    Barcelona, Catalunya [Cataluña], 08041, Spain

    Contact Phone: •••-•••-••••

  • Local Institution - 0004

    NOT_YET_RECRUITING

    Prague, Praha 5, 150 06, Czechia

    Contact

  • Local Institution - 0007

    NOT_YET_RECRUITING

    Camperdown, New South Wales, 2050, Australia

    Contact

  • Local Institution - 0008

    WITHDRAWN

    Brisbane, Queensland, 4029, Australia

  • Local Institution - 0013

    NOT_YET_RECRUITING

    Clayton, Victoria, 3168, Australia

    Contact

  • Local Institution - 0017

    NOT_YET_RECRUITING

    Lodz, Łódź Voivodeship, 93-513, Poland

    Contact

  • Local Institution - 0031

    NOT_YET_RECRUITING

    Hamburg, 20246, Germany

    Contact

  • Local Institution - 0038

    NOT_YET_RECRUITING

    São Paulo, 01508-010, Brazil

    Contact

  • Local Institution - 0039

    NOT_YET_RECRUITING

    Porto Alegre, 0, Brazil

    Contact

  • Local Institution - 0040

    NOT_YET_RECRUITING

    Salvador, Estado de Bahia, 41253-190, Brazil

    Contact

  • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy w Gliwicach

    RECRUITING

    Gliwice, Silesian Voivodeship, 44-100, Poland

    Contact Phone: •••-•••-••••

  • Revmatologicky ustav

    RECRUITING

    Prague, 12850, Czechia

    Contact Phone: •••-•••-••••

  • Sheba Medical Center

    RECRUITING

    Ramat Gan, Central District, 5262100, Israel

    Contact Phone: •••-•••-••••

  • Szpital Specjalistyczny nr 1 w Bytomiu

    RECRUITING

    Bytom, Silesian Voivodeship, 41-902, Poland

    Contact Phone: •••-•••-••••

  • Universitaetsklinikum Duesseldorf

    RECRUITING

    Düsseldorf, North Rhine-Westphalia, 40225, Germany

    Contact Phone: •••-•••-••••

  • Universitaetsklinikum Schleswig-Holstein Campus Kiel

    RECRUITING

    Kiel, Schleswig-Holstein, 24105, Germany

    Contact Phone: •••-•••-••••

  • Universitätsklinikum Carl Gustav Carus an der TU Dresden

    RECRUITING

    Dresden, 01307, Germany

    Contact Phone: •••-•••-••••

  • Uniwersyteckie Centrum Kliniczne

    RECRUITING

    Gdansk, Pomeranian Voivodeship, 80-952, Poland

    Contact Phone: •••-•••-••••