Donor immune cells aim to tame autoimmune attacks
NCT ID NCT07115745
First seen Jun 27, 2026 · Last updated Jul 15, 2026 · Updated 2 times
Summary
This early-stage study tests a new treatment made from healthy donor immune cells (CAR T cells) for people with severe autoimmune diseases like lupus that haven't responded to standard therapies. The goal is to see if these cells can safely target and calm the overactive immune system. About 125 participants will receive the treatment and be monitored for side effects and effectiveness.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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ARENSIA Exploratory Medicine
RECRUITINGCluj-Napoca, Cluj, 400015, Romania
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Brigham And Womens Hospital
RECRUITINGBoston, Massachusetts, 02115, United States
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CHU Strasbourg-Hautepierre
RECRUITINGStrasbourg, Alsace, 67098, France
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Charité - Universitaetsmedizin Berlin - Campus Bejnamin Franklin
RECRUITINGBerlin, 10117, Germany
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Duke University
RECRUITINGDurham, North Carolina, 27705-2771, United States
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Fundeni Clinical Institute
RECRUITINGBucharest, 022328, Romania
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Hadassah Medical Center
RECRUITINGJerusalem, 9112001, Israel
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Hopital Claude Huriez - CHU de Lille
RECRUITINGLille, Nord, 59037, France
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Hospital Universitari Vall d'Hebron
RECRUITINGBarcelona, Barcelona [Barcelona], 08035, Spain
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Hospital Universitario Ramón y Cajal
RECRUITINGMadrid, Madrid, Comunidad de, 28034, Spain
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Hospital de la Santa Creu i Sant Pau
RECRUITINGBarcelona, Catalunya [Cataluña], 08041, Spain
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Local Institution - 0004
NOT_YET_RECRUITINGPrague, Praha 5, 150 06, Czechia
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Local Institution - 0007
WITHDRAWNCamperdown, New South Wales, 2050, Australia
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Local Institution - 0008
WITHDRAWNBrisbane, Queensland, 4029, Australia
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Local Institution - 0013
WITHDRAWNClayton, Victoria, 3168, Australia
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Local Institution - 0017
WITHDRAWNLodz, Łódź Voivodeship, 93-513, Poland
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Local Institution - 0031
WITHDRAWNHamburg, 20246, Germany
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Local Institution - 0038
NOT_YET_RECRUITINGSão Paulo, 01508-010, Brazil
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Local Institution - 0039
NOT_YET_RECRUITINGPorto Alegre, 0, Brazil
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Local Institution - 0040
NOT_YET_RECRUITINGSalvador, Estado de Bahia, 41253-190, Brazil
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Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy w Gliwicach
RECRUITINGGliwice, Silesian Voivodeship, 44-100, Poland
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Revmatologicky ustav
RECRUITINGPrague, 12850, Czechia
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Sheba Medical Center
RECRUITINGRamat Gan, Central District, 5262100, Israel
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Szpital Specjalistyczny nr 1 w Bytomiu
RECRUITINGBytom, Silesian Voivodeship, 41-902, Poland
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Universitaetsklinikum Duesseldorf
RECRUITINGDüsseldorf, North Rhine-Westphalia, 40225, Germany
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Universitaetsklinikum Schleswig-Holstein Campus Kiel
RECRUITINGKiel, Schleswig-Holstein, 24105, Germany
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Universitätsklinikum Carl Gustav Carus an der TU Dresden
RECRUITINGDresden, 01307, Germany
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Uniwersyteckie Centrum Kliniczne
RECRUITINGGdansk, Pomeranian Voivodeship, 80-952, Poland
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Engineered immune cells take aim at Hard-to-Treat autoimmune diseases
- Video game rehab boosts muscle power in rare muscle disease
- New cell therapy hopes to tame tough autoimmune diseases
- Engineered immune cells aim to tame stubborn autoimmune diseases
- Experimental cell therapy takes on lupus and other autoimmune diseases