Experimental cancer drug trial halted early

NCT ID NCT05252416

First seen Jan 08, 2026 · Last updated May 16, 2026 · Updated 17 times

Summary

This early-stage study tested an experimental drug called BLU-222 in 50 people with advanced solid tumors (like breast, ovarian, or stomach cancer) that had stopped responding to standard treatments. The goal was to find a safe dose and see if the drug could shrink tumors. The study was terminated early, so results are limited.

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Contacts and locations

Locations

  • Columbia University Herbert Irving Comprehensive Cancer Center

    New York, New York, 10032, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Florida Cancer Specialists

    Sarasota, Florida, 34232, United States

  • Fondazione IRCCS Istituto Nazionale dei Tumori

    Milan, 20133, Italy

  • Fondazione Policlinico Universitario A Gemelli-Rome

    Rome, 00168, Italy

  • Henry Ford Health System

    Detroit, Michigan, 48202, United States

  • Hospital of the Fox Chase Cancer Center

    Philadelphia, Pennsylvania, 19111, United States

  • Instituto Europeo di Oncologia

    Milan, 20141, Italy

  • Johns Hopkins Sidney Kimmel Comprehensive Cancer Center (SKCCC)

    Baltimore, Maryland, 21287, United States

  • MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Montefiore Medical Center

    New York, New York, 10461, United States

  • OU Health Stephenson Cancer Center

    Oklahoma City, Oklahoma, 73104, United States

  • St Bartholomew's Hospital

    London, Middlesex, EC1A 7BE, United Kingdom

  • Stanford Women's Cancer Center

    Stanford, California, 94305, United States

  • UCSF Helen Diller Family Comprehensive Cancer Center

    San Francisco, California, 94158, United States

  • UNC Hospitals at Chapel Hill - The University of North Carolina at Chapel Hill

    Chapel Hill, North Carolina, 27514, United States

  • University of Arkansas for Medical Sciences

    Little Rock, Arkansas, 72205, United States

  • University of Chicago Medical Center

    Chicago, Illinois, 60637, United States

  • University of Utah - Huntsman Cancer Institute - PPDS

    Salt Lake City, Utah, 84112, United States

  • University of Virginia Comprehensive Cancer Center

    Charlottesville, Virginia, 22903, United States

  • Vanderbilt Breast Center at One Hundred Oaks

    Nashville, Tennessee, 37204, United States

Conditions

Explore the condition pages connected to this study.