Could a heart drug boost bladder cancer treatment?
NCT ID NCT07353294
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests whether adding the blood pressure drug propranolol to standard immunotherapy and chemotherapy can help shrink bladder cancer that has spread to lymph nodes before surgery. The study enrolls 12 patients and primarily checks for safety and side effects. Researchers hope propranolol may overcome resistance in lymph node tumors by blocking stress signals.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- propranolol (a beta-blocker drug) combined with tislelizumab (an immunotherapy) and gemcitabine/cisplatin (chemotherapy)
- What this could lead to
- If successful, this could point toward a new treatment approach for bladder cancer that has spread to lymph nodes, potentially improving response rates.
- What could go wrong
- This is a very early phase 1 trial with only 12 participants, focused on safety. It is too small to prove effectiveness, and the combination may cause significant side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Guangzhou, Guangdong, 510000, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- GPS for surgeons: navigation tech aims to simplify cancer lymph node removal
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- Stomach cancer study may spare some patients unnecessary surgery
- Surgeons try High-Tech goggles to map cancer before cutting