New pill targets genetic weakness in Tough-to-Treat bladder cancers
NCT ID NCT03047213
Summary
This study is testing an oral drug called sapanisertib for people with advanced bladder cancer that has a specific genetic mutation (TSC1 or TSC2) and has stopped responding to standard platinum-based chemotherapy. The goal is to see if the drug can shrink tumors and control the cancer's growth by blocking a key cellular pathway. It is a small, Phase 2 trial focused on safety and initial effectiveness for this specific group of patients.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah, 84112, United States
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Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, 21287, United States
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Keck Medical Center of USC Pasadena
Pasadena, California, 91105, United States
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Los Angeles General Medical Center
Los Angeles, California, 90033, United States
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Nebraska Medicine-Bellevue
Bellevue, Nebraska, 68123, United States
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Nebraska Medicine-Village Pointe
Omaha, Nebraska, 68118, United States
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Northwestern University
Chicago, Illinois, 60611, United States
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Smilow Cancer Center/Yale-New Haven Hospital
New Haven, Connecticut, 06510, United States
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UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, 27599, United States
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USC / Norris Comprehensive Cancer Center
Los Angeles, California, 90033, United States
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University of California Davis Comprehensive Cancer Center
Sacramento, California, 95817, United States
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University of Kansas Clinical Research Center
Fairway, Kansas, 66205, United States
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University of Michigan Rogel Cancer Center
Ann Arbor, Michigan, 48109, United States
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University of Nebraska Medical Center
Omaha, Nebraska, 68198, United States
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University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania, 15232, United States
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Vanderbilt Breast Center at One Hundred Oaks
Nashville, Tennessee, 37204, United States
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Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, 37232, United States
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Yale University
New Haven, Connecticut, 06520, United States
Conditions
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