New drug BL-M11D1 takes aim at tough leukemia in early trial

NCT ID NCT06714591

Recruiting now Disease control Sponsor: SystImmune Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 22, 2026 · Updated 2 times

Summary

This early-phase trial is testing a new drug called BL-M11D1 in 120 adults with acute myeloid leukemia that has come back or not responded to standard treatments. The drug is designed to target and deliver a toxin directly to leukemia cells. The main goals are to check safety, find the right dose, and get a first look at whether it might help control the disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BL-M11D1 (a targeted drug that delivers a toxin to leukemia cells)
What this could lead to: If it works, this could point toward a new treatment option for people with hard-to-treat acute myeloid leukemia.
What could go wrong: This is a very early Phase 1 trial, so the main goal is safety, not proof of effectiveness. It may not work, and side effects could be serious.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RELAPSED/REFRACTORY ACUTE MYELOID LEUKEMIA

Contacts and locations

Locations

City of Hope
RECRUITING

Duarte, California, 91010, United States
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
John Theurer Cancer Center-Hackensack
RECRUITING

Hackensack, New Jersey, 07601, United States
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
Northwestern Memorial Hospital
RECRUITING

Chicago, Illinois, 60611, United States
Oncology Hematology Care Clinical Trials, LLC
RECRUITING

Cincinnati, Ohio, 45236, United States
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States
SCRI -TriStar BMT
RECRUITING

Nashville, Tennessee, 37203, United States
START Midwest/The Cancer and Hematology Center
RECRUITING

Grand Rapids, Michigan, 49546, United States
Temple Health Fox Chase Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19111, United States
The Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
RECRUITING

Baltimore, Maryland, 21287, United States
UCLA Ronald Reagan Medical Center
RECRUITING

Los Angeles, California, 90095, United States
University of Colorado Anschutz Medical Campus
RECRUITING

Aurora, Colorado, 80045, United States
Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States
WVCI Oncology Associates of Oregon
RECRUITING

Eugene, Oregon, 24224, United States
Yale Cancer Center, Smilow Cancer Hospital at Yale New Haven
RECRUITING

New Haven, Connecticut, 06511, United States

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