New drug cocktail aims to wipe out breast cancer before surgery
NCT ID NCT06891833
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new drug called BL-M07D1, given alone or with pertuzumab, against the standard treatment (taxane + trastuzumab and pertuzumab) for HER2-positive breast cancer before surgery. About 120 women with stage II-III breast cancer will participate. The goal is to see if the new approach leads to a complete disappearance of cancer in the breast tissue at the time of surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- BL-M07D1 (a drug given by IV) and pertuzumab (another drug given by IV)
- What this could lead to
- If successful, this could offer a more effective pre-surgery treatment option for HER2-positive breast cancer, potentially improving the chance of a complete response.
- What could go wrong
- This is an early-to-mid stage trial with only 120 participants, so results may not apply to everyone. The new drug combination may not work better than standard therapy and could have unknown side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Anhui Provincial Cancer Hospital
NOT_YET_RECRUITINGHefei, Anhui, China
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Anyang Cancer Hospital
NOT_YET_RECRUITINGAnyang, Henan, China
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Cancer Hospital Chinese Academy of Medical Sciences, Shenzhen Center
NOT_YET_RECRUITINGShenzhen, Guangdong, China
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Fudan University Shanghai Cancer Center
RECRUITINGShanghai, Shanghai Municipality, China
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Fujian Medical University Union Hospital
NOT_YET_RECRUITINGFuzhou, Fujian, China
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Guangdong Maternal and Child Health Center
NOT_YET_RECRUITINGGuangzhou, Guangdong, China
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Guangxi Medical University Cancer Hospital
NOT_YET_RECRUITINGNanning, Guangxi, China
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Hainan General Hospital
NOT_YET_RECRUITINGHaikou, Hainan, China
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Harbin Medical University Cancer Hospital
NOT_YET_RECRUITINGHarbin, Heilongjiang, China
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Henan Provincial People's Hospital
NOT_YET_RECRUITINGZhengzhou, Henan, China
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Hunan Cancer Hospital
NOT_YET_RECRUITINGChangsha, Hunan, China
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Liuzhou People's Hospital
NOT_YET_RECRUITINGLiuzhou, Guangxi, China
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Shaanxi Provincial People's Hospital
NOT_YET_RECRUITINGXi'an, Shaanxi, China
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Shandong Cancer Hospital
NOT_YET_RECRUITINGJinan, Shandong, China
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Shanxi Bethune Hospital
NOT_YET_RECRUITINGTaiyuan, Shanxi, China
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Shanxi Cancer Hospital
NOT_YET_RECRUITINGTaiyuan, Shanxi, China
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Sichuan Cancer Hospital
NOT_YET_RECRUITINGChengdu, Sichuan, China
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Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
NOT_YET_RECRUITINGGuangzhou, Guangdong, China
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The First Affiliated Hospital of Bengbu Medical University
NOT_YET_RECRUITINGBengbu, Anhui, China
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The First Affiliated Hospital of Chongqing Medical University
NOT_YET_RECRUITINGChongqing, Chongqing Municipality, China
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The First Affiliated Hospital of Henan University of science and technology
NOT_YET_RECRUITINGLuoyang, Henan, China
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The First Affiliated Hospital of Nanchang University
NOT_YET_RECRUITINGNanchang, Jiangxi, China
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The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital)
NOT_YET_RECRUITINGHefei, Anhui, China
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The First Affiliated Hospital of Xi'an Jiaotong University
NOT_YET_RECRUITINGXi'an, Shaanxi, China
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The First Affiliated Hospital, Zhejiang University School of Medicine
NOT_YET_RECRUITINGHangzhou, Zhejiang, China
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The Fourth Hospital of Hebei Medical University
NOT_YET_RECRUITINGShijiazhuang, Hebei, China
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The Second Xiangya Hospital of Central South University
NOT_YET_RECRUITINGChangsha, Hunan, China
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Tianjin Cancer Hospital
NOT_YET_RECRUITINGTianjin, Tianjin Municipality, China
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Xingtai People's Hospital
NOT_YET_RECRUITINGXingtai, Hebei, China
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Zhejiang Cancer Hospital
NOT_YET_RECRUITINGHangzhou, Zhejiang, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a triple drug combo shrink HER2-Positive breast tumors before surgery?
- Can an extra radiation dose keep HER2+ breast cancer at bay?
- Can a drug cocktail cure metastatic breast cancer? a trial aims to find out
- Can less chemo be enough? a trial challenges standard treatment for HER2-Positive breast cancer
- Can a new drug outsmart resistant breast cancer?
- Can a new targeted drug outperform the current standard for HER2-Positive breast cancer?