New drug combo aims to boost stem cell harvest in myeloma patients

NCT ID NCT03246529

Ongoing Disease control Sponsor: BioLineRx, Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether adding BL-8040 to standard G-CSF helps collect more stem cells for transplant in multiple myeloma patients. About 180 participants received either the combo or a placebo. The goal is to see if more patients can collect enough cells in fewer sessions, making the transplant process smoother.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BL-8040 (a drug to help release stem cells) plus G-CSF (a standard growth factor)
What this could lead to: If successful, this combination could make stem cell collection faster and more reliable for multiple myeloma patients needing a transplant.
What could go wrong: This is a late-stage trial, but results are not yet final. The drug may not improve collection enough to change standard care, and side effects from BL-8040 are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA

Contacts and locations

Locations

Central Hospital of Southern Pest National Institute of Hematology and Infectious Diseases

Budapest, 1097, Hungary
Div. Clinicizzata di Ematologia - Policlinico Vittorio Emanuele

Catania, 95124, Italy
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital University Ramon y Cajal

Madrid, 135250, Spain
Hospital de La Santa Creu I Sant Pau

Barcelona, 08041, Spain
Huntsman Cancer Institute in University of Utah

Salt Lake City, Utah, 84112, United States
Loyola University Medical Center

Chicago, Illinois, 60611, United States
MD Anderson Cancer Center

Houston Texas, Texas, 77030, United States
Mayo Clinic

Rochester, Minnesota, 55902, United States
Presidio Ospedaliero Morelli Viale Europa

Reggio Calabria, 89133, Italy
The Washington University School of Medicine

St Louis, Missouri, 63110, United States
UCLA Medical Center

Los Angeles, California, 167817, United States
University of Cincinnati

Cincinnati, Ohio, 45221, United States
University of Debrecen

Debrecen, 4032, Hungary
University of Florida

Gainesville, Florida, 100278, United States
University of Koln

Cologne, Koln, 50923, Germany
University of Maryland

Baltimore, Maryland, 21201, United States
University of Miami

Miami, Florida, 33136, United States

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