New drug aims to destroy lung Cancer's fuel source

NCT ID NCT06685718

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 29 times

Summary

This early-phase study tests a new drug, BG-60366, designed to break down a faulty protein (mutant EGFR) that drives non-small cell lung cancer. About 33 adults with advanced or spreading lung cancer who have already tried other treatments will receive the drug to see if it is safe and shrinks tumors. The goal is to control the disease, not cure it, as ongoing management is expected.

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Contacts and locations

Locations

  • Austin Health

    Heidelberg, Victoria, VIC 3084, Australia

  • Beijing Cancer Hospital

    Beijing, Beijing Municipality, 100142, China

  • Blacktown Cancer and Haematology Centre

    Blacktown, New South Wales, NSW 2148, Australia

  • Cancer Research South Australia

    Adelaide, South Australia, SA 5000, Australia

  • Chungbuk National University Hospital

    Cheongju-si, Chungcheongbukdo, 28644, South Korea

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02215-5418, United States

  • Fondazione Irccs San Gerardo Dei Tintori Sc Oncologia

    Monza, 20900, Italy

  • Fondazione Policlinico Universitario Agostino Gemelli

    Roma, 00168, Italy

  • Guangdong Provincial Peoples Hospital Huifu Branch

    Guangzhou, Guangdong, 510120, China

  • H Puerta de Hierro Majadahonda

    Majadahonda, 28222, Spain

  • Harbour Cancer and Wellness

    Auckland, 1023, New Zealand

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Universitario Vall Dhebron

    Barcelona, 08035, Spain

  • Liverpool Hospital

    Liverpool, New South Wales, NSW 2170, Australia

  • Memorial Sloan Kettering Cancer Center Mskcc

    New York, New York, 10065-6800, United States

  • Ohio State University

    Columbus, Ohio, 43210-1132, United States

  • Peter Maccallum Cancer Centre

    Melbourne, Victoria, VIC 3000, Australia

  • Princess Alexandra Hospital

    Woolloongabba, Queensland, QLD 4102, Australia

  • Samsung Medical Center

    GangnamGu, Seoul Teugbyeolsi, 06351, South Korea

  • Seoul National University Hospital

    Seoul, Seoul Teugbyeolsi, 03080, South Korea

  • Severance Hospital Yonsei University Health System

    SeodaemunGu, Seoul Teugbyeolsi, 03722, South Korea

  • Shanxi Bethune Hospital

    Taiyuan, Shanxi, 030032, China

  • Sir Run Run Shaw Hospital, Zhejiang University School of Medicineqiantang Branch

    Hangzhou, Zhejiang, 310018, China

  • The Second Affiliated Hospital of Nanchang University

    Nanchang, Jiangxi, 330006, China

  • The Tumor Hospital Affiliated to Guangxi Medical Universitywuxiang Branch

    Nanning, Guangxi, 530201, China

  • The University of Texas Md Anderson Cancer Center

    Houston, Texas, 77030-4009, United States

  • Tianjin Medical University Cancer Institute and Hospital

    Tianjin, Tianjin Municipality, 300060, China

  • University of Colorado

    Denver, Colorado, 80202-1702, United States

  • Washington University School of Medicine Siteman Cancer Center

    St Louis, Missouri, 63110-1032, United States

Conditions

Explore the condition pages connected to this study.