New antibody aims to calm eczema Flare-Ups from the inside

NCT ID NCT07105488

Recruiting now Disease control Sponsor: Bluefin Biomedicine, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an experimental drug called BFB759, a lab-made antibody that blocks several inflammatory signals at once. Researchers want to see if it can reduce redness, swelling, and itching in adults with moderate-to-severe eczema that hasn't improved with creams. About 225 participants will receive either the drug or a placebo for up to 40 weeks, and doctors will track how their skin responds.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

BFB759 (a lab-made antibody that blocks multiple inflammatory signals)

What this could lead to

If successful, this could point toward a new treatment option for people with moderate-to-severe eczema that is not controlled by creams.

What could go wrong

This is an early Phase 2 study with only 225 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are still being evaluated.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

atopic eczema Eczema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATOPIC DERMATITIS (AD)

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Antelope Valley Clinical Trials
RECRUITING

Lancaster, California, 93534, United States
Apex Clinical Research Center, LLC
RECRUITING

Canton, Ohio, 44718, United States
Apex Clinical Research Center, LLC
RECRUITING

Mayfield Heights, Ohio, 44124, United States
Bobby Buka, MD
RECRUITING

New York, New York, 10012, United States
Bobby Buka, MD (The Dermatology Specialist)
RECRUITING

New York, New York, 10012, United States
CCR Ostrava
RECRUITING

Ostrava, Czechia
CRS Clinical Research Services Berlin GmbH
RECRUITING

Berlin, Germany
Center for Skin Science and Innovation
RECRUITING

Fort Lauderdale, Florida, 33308, United States
Centre de Recherche Saint-Louis (Montreal)
RECRUITING

Montreal, Quebec, H1Y 3L1, Canada
Centrum Badan Klinicznych JCI
RECRUITING

Krakow, Poland
Centrum Zdrowia Dziecka i Rodziny im. Jana Pawla II w Sosnowcu, Osrodek Badan Klinicznych
RECRUITING

Sosnowiec, Poland
ClinicMed Daniluk, Nowak
RECRUITING

Bialystok, Poland
Clinical Trials Management - S
RECRUITING

Tampa, Florida, 33607, United States
Clinical Trials Management - S
RECRUITING

Covington, Louisiana, 70433, United States
Clinical Trials Management, LLC
RECRUITING

Metairie, Louisiana, 70006, United States
Clintrial s.r.o.
RECRUITING

Prague, Czechia
Conquest Research LLC
RECRUITING

Winter Park, Florida, 32789, United States
DBA Dermatology of Seattle & Bellevue -S
RECRUITING

Burien, Washington, 98618, United States
DERMAPOLIS Medical Dermatology Center dr n. med. Edyta Gębska
RECRUITING

Chorzów, Poland
DJL Clinical Research
RECRUITING

Charlotte, North Carolina, 28277, United States
Dermatology Research Institute
RECRUITING

Calgary, Alberta, T2J 7E1, Canada
Dermatology Treatment & Research Center
RECRUITING

Dallas, Texas, 75230, United States
EMC Instytut Medyczny SA - Prywatna Lecznica Certus Szpital i Ambulatorium
RECRUITING

Poznan, Poland
Elias Research Associates
RECRUITING

Missoula, Montana, 59808, United States
Equity Medical, LLC
RECRUITING

The Bronx, New York, 10455, United States
Fachklinik Bad Bentheim - Dermatology Hospital Bad Bentheim
RECRUITING

Bad Bentheim, Germany
Florida Academic Dermatology Center Res and Edu, LLC
RECRUITING

Coral Gables, Florida, 33134, United States
Focus Clinical Research, LLC -S
RECRUITING

West Hills, California, 91307, United States
Gsi Clinical Research
RECRUITING

Margate, Florida, 33063, United States
Hospital Asil de Granollers
RECRUITING

Granollers, Spain
Hospital Clinico San Carlos
RECRUITING

Madrid, Spain
Hospital General Universitario de Alicante - Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL) - Fundacion FISABIO
RECRUITING

Alicante, Spain
Hospital Ramón y Cajal and Grupo Pedro Jaén
RECRUITING

Madrid, Spain
Hospital Universitario Reina Sofia
RECRUITING

Córdoba, Spain
International Clinical Research - Tennesee, LLC
RECRUITING

Murfreesboro, Tennessee, 37130, United States
JDR Dermatology Research
RECRUITING

Las Vegas, Nevada, 89145, United States
Klinika Badawcza Centrum Badan Klinicznych
RECRUITING

Malbork, Poland
Klinika Zdybski - Dermedic
RECRUITING

Ostrowiec Świętokrzyski, Poland
Lenus Research & Medical Group, LLC
RECRUITING

Sweetwater, Florida, 33172, United States
MI Skin Innovations
RECRUITING

Northville, Michigan, 48167, United States
MICS Centrum Medyczne
RECRUITING

Torun, Poland
Manufaktura Urody
RECRUITING

Warsaw, Poland
Marvel Clinical Research
RECRUITING

Huntington Beach, California, 92647, United States
Mazowieckie Centrum Badan Klinicznych
RECRUITING

Grodzisk Mazowiecki, Poland
Medconsult Lovech
RECRUITING

Lovech, Bulgaria
Medical Center Medconsult Burgas EOOD
RECRUITING

Burgas, Bulgaria
Medical Centre Asklepii OOD
RECRUITING

Dupnitsa, Bulgaria
Medisearch, LLC
RECRUITING

Saint Joseph, Missouri, 64506, United States
MetroBoston Clinical Partners
RECRUITING

Brighton, Massachusetts, 02135, United States
Mountain West Derm - Blackhart PLLC dba Skin Cancer and Dermatology Institute
RECRUITING

Phoenix, Arizona, 85008, United States
Mountain West Derm - Blackhart PLLC dba Skin Cancer and Dermatology Institute
RECRUITING

Reno, Nevada, 89509, United States
Mountain West Derm - Blackhart PLLC dba Skin Cancer and Dermatology Institute
RECRUITING

Sparks, Nevada, 89436, United States
NZOZ Centrum Medyczne KERmed
RECRUITING

Bydgoszcz, Poland
NorCal Clinical Research
RECRUITING

Rocklin, California, 95765, United States
Oakland Hills Dermatology
RECRUITING

Auburn Hills, Michigan, 48326, United States
Optima Research-Boardman
RECRUITING

Boardman, Ohio, 44512, United States
PI House
RECRUITING

Gdansk, Poland
Pratia Pardubice
RECRUITING

Pardubice, Czechia
Private Dermatovenerology Practice
RECRUITING

Prague, Czechia
Probity Medical Research
RECRUITING

Los Angeles, California, 90017, United States
Probity Medical Research
RECRUITING

Mississauga, Ontario, L4Y 4C5, Canada
Probity Medical Research
RECRUITING

Richmond Hill, Ontario, L4B 1A5, Canada
Progressive Clinical Research
RECRUITING

San Antonio, Texas, 78213, United States
Prywatna Praktyka Lekarska Ewa Ring
RECRUITING

Warsaw, Poland
Saskatoon Dermatology Centre
RECRUITING

Saskatoon, Saskatchewan, S7T 0G3, Canada
Schweiger Dermatology, PC R.D.
RECRUITING

Hackensack, New Jersey, 07601, United States
Skin Cancer and Dermatology Institute
RECRUITING

Phoenix, Arizona, 85008, United States
Skin Cancer and Dermatology Institute
RECRUITING

Douglasville, Georgia, 30135, United States
Skin Cancer and Dermatology Institute
RECRUITING

Reno, Nevada, 89509, United States
Skin Cancer and Dermatology Institute
RECRUITING

Sparks, Nevada, 89436, United States
Skin Care Research
RECRUITING

Boca Raton, Florida, 33486, United States
Southeast Research Specialists, LLC
RECRUITING

Douglasville, Georgia, 30135, United States
Stride Clinical Research
RECRUITING

Missouri City, Texas, 77459, United States
Stryde Research-Epiphany Dermatology
RECRUITING

Southlake, Texas, 76092, United States
Synexus Polska Sp. z o.o.
RECRUITING

Gdansk, Poland
T. Joseph Raoof Md, Inc
RECRUITING

Encino, California, 91436, United States
The Indiana Clinical Trials Center
RECRUITING

Plainfield, Indiana, 46168, United States
Therapia Nova Sp z o.o
RECRUITING

Warsaw, Poland
UPMC
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
UW Wroclaw
RECRUITING

Wroclaw, Poland
Universitaetsklinikum Muenster (UKM) - Klinik fuer Hautkrankheiten
RECRUITING

Münster, Germany
Universitaetsmedizin Goettingen
RECRUITING

Göttingen, Germany
University Hospital Heidelberg Occupational Dermatology Department of Dermatology
RECRUITING

Heidelberg, Germany
Vida Clinical Research
RECRUITING

Edmonton, Alberta, T6H 4J8, Canada
Virginia Dermatology & Skin Cancer Center
RECRUITING

Norfolk, Virginia, 23502, United States
Vitality Clinical Trials LLC
RECRUITING

Woodbury, New York, 11797, United States
York Dermatology
RECRUITING

Richmond Hill, Ontario, L4B 3L4, Canada
Ziaderm Research LLC
RECRUITING

North Miami Beach, Florida, 33162, United States