New antibody aims to calm eczema Flare-Ups from the inside

NCT ID NCT07105488

Ongoing Disease control Sponsor: Bluefin Biomedicine, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 2 times

Summary

This study tests an experimental drug called BFB759, a lab-made antibody that blocks several inflammatory signals at once. Researchers want to see if it can reduce redness, swelling, and itching in adults with moderate-to-severe eczema that hasn't improved with creams. About 225 participants will receive either the drug or a placebo for up to 40 weeks, and doctors will track how their skin responds.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BFB759 (a lab-made antibody that blocks multiple inflammatory signals)
What this could lead to: If successful, this could point toward a new treatment option for people with moderate-to-severe eczema that is not controlled by creams.
What could go wrong: This is an early Phase 2 study with only 225 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are still being evaluated.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atopic eczema Eczema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATOPIC DERMATITIS (AD)

Contacts and locations

Locations

Antelope Valley Clinical Trials

Lancaster, California, 93534, United States
Apex Clinical Research Center, LLC

Canton, Ohio, 44718, United States
Apex Clinical Research Center, LLC

Mayfield Heights, Ohio, 44124, United States
Bobby Buka, MD

New York, New York, 10012, United States
Bobby Buka, MD (The Dermatology Specialist)

New York, New York, 10012, United States
CCR Ostrava

Ostrava, Czechia
CRS Clinical Research Services Berlin GmbH

Berlin, Germany
Center for Skin Science and Innovation

Fort Lauderdale, Florida, 33308, United States
Centre de Recherche Saint-Louis (Montreal)

Montreal, Quebec, H1Y 3L1, Canada
Centrum Badan Klinicznych JCI

Krakow, Poland
Centrum Zdrowia Dziecka i Rodziny im. Jana Pawla II w Sosnowcu, Osrodek Badan Klinicznych

Sosnowiec, Poland
ClinicMed Daniluk, Nowak

Bialystok, Poland
Clinical Trials Management - S

Tampa, Florida, 33607, United States
Clinical Trials Management - S

Covington, Louisiana, 70433, United States
Clinical Trials Management, LLC

Metairie, Louisiana, 70006, United States
Clintrial s.r.o.

Prague, Czechia
Conquest Research LLC

Winter Park, Florida, 32789, United States
DBA Dermatology of Seattle & Bellevue -S

Burien, Washington, 98618, United States
DERMAPOLIS Medical Dermatology Center dr n. med. Edyta Gębska

Chorzów, Poland
DJL Clinical Research

Charlotte, North Carolina, 28277, United States
Dermatology Research Institute

Calgary, Alberta, T2J 7E1, Canada
Dermatology Treatment & Research Center

Dallas, Texas, 75230, United States
EMC Instytut Medyczny SA - Prywatna Lecznica Certus Szpital i Ambulatorium

Poznan, Poland
Elias Research Associates

Missoula, Montana, 59808, United States
Equity Medical, LLC

The Bronx, New York, 10455, United States
Fachklinik Bad Bentheim - Dermatology Hospital Bad Bentheim

Bad Bentheim, Germany
Florida Academic Dermatology Center Res and Edu, LLC

Coral Gables, Florida, 33134, United States
Focus Clinical Research, LLC -S

West Hills, California, 91307, United States
Gsi Clinical Research

Margate, Florida, 33063, United States
Hospital Asil de Granollers

Granollers, Spain
Hospital Clinico San Carlos

Madrid, Spain
Hospital General Universitario de Alicante - Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL) - Fundacion FISABIO

Alicante, Spain
Hospital Ramón y Cajal and Grupo Pedro Jaén

Madrid, Spain
Hospital Universitario Reina Sofia

Córdoba, Spain
International Clinical Research - Tennesee, LLC

Murfreesboro, Tennessee, 37130, United States
JDR Dermatology Research

Las Vegas, Nevada, 89145, United States
Klinika Badawcza Centrum Badan Klinicznych

Malbork, Poland
Klinika Zdybski - Dermedic

Ostrowiec Świętokrzyski, Poland
Lenus Research & Medical Group, LLC

Sweetwater, Florida, 33172, United States
MI Skin Innovations

Northville, Michigan, 48167, United States
MICS Centrum Medyczne

Torun, Poland
Manufaktura Urody

Warsaw, Poland
Marvel Clinical Research

Huntington Beach, California, 92647, United States
Mazowieckie Centrum Badan Klinicznych

Grodzisk Mazowiecki, Poland
Medconsult Lovech

Lovech, Bulgaria
Medical Center Medconsult Burgas EOOD

Burgas, Bulgaria
Medical Centre Asklepii OOD

Dupnitsa, Bulgaria
Medisearch, LLC

Saint Joseph, Missouri, 64506, United States
MetroBoston Clinical Partners

Brighton, Massachusetts, 02135, United States
Mountain West Derm - Blackhart PLLC dba Skin Cancer and Dermatology Institute

Phoenix, Arizona, 85008, United States
Mountain West Derm - Blackhart PLLC dba Skin Cancer and Dermatology Institute

Reno, Nevada, 89509, United States
Mountain West Derm - Blackhart PLLC dba Skin Cancer and Dermatology Institute

Sparks, Nevada, 89436, United States
NZOZ Centrum Medyczne KERmed

Bydgoszcz, Poland
NorCal Clinical Research

Rocklin, California, 95765, United States
Oakland Hills Dermatology

Auburn Hills, Michigan, 48326, United States
Optima Research-Boardman

Boardman, Ohio, 44512, United States
PI House

Gdansk, Poland
Pratia Pardubice

Pardubice, Czechia
Private Dermatovenerology Practice

Prague, Czechia
Probity Medical Research

Los Angeles, California, 90017, United States
Probity Medical Research

Mississauga, Ontario, L4Y 4C5, Canada
Probity Medical Research

Richmond Hill, Ontario, L4B 1A5, Canada
Progressive Clinical Research

San Antonio, Texas, 78213, United States
Prywatna Praktyka Lekarska Ewa Ring

Warsaw, Poland
Saskatoon Dermatology Centre

Saskatoon, Saskatchewan, S7T 0G3, Canada
Schweiger Dermatology, PC R.D.

Hackensack, New Jersey, 07601, United States
Skin Cancer and Dermatology Institute

Phoenix, Arizona, 85008, United States
Skin Cancer and Dermatology Institute

Douglasville, Georgia, 30135, United States
Skin Cancer and Dermatology Institute

Reno, Nevada, 89509, United States
Skin Cancer and Dermatology Institute

Sparks, Nevada, 89436, United States
Skin Care Research

Boca Raton, Florida, 33486, United States
Southeast Research Specialists, LLC

Douglasville, Georgia, 30135, United States
Stride Clinical Research

Missouri City, Texas, 77459, United States
Stryde Research-Epiphany Dermatology

Southlake, Texas, 76092, United States
Synexus Polska Sp. z o.o.

Gdansk, Poland
T. Joseph Raoof Md, Inc

Encino, California, 91436, United States
The Indiana Clinical Trials Center

Plainfield, Indiana, 46168, United States
Therapia Nova Sp z o.o

Warsaw, Poland
UPMC

Pittsburgh, Pennsylvania, 15213, United States
UW Wroclaw

Wroclaw, Poland
Universitaetsklinikum Muenster (UKM) - Klinik fuer Hautkrankheiten

Münster, Germany
Universitaetsmedizin Goettingen

Göttingen, Germany
University Hospital Heidelberg Occupational Dermatology Department of Dermatology

Heidelberg, Germany
Vida Clinical Research

Edmonton, Alberta, T6H 4J8, Canada
Virginia Dermatology & Skin Cancer Center

Norfolk, Virginia, 23502, United States
Vitality Clinical Trials LLC

Woodbury, New York, 11797, United States
York Dermatology

Richmond Hill, Ontario, L4B 3L4, Canada
Ziaderm Research LLC

North Miami Beach, Florida, 33162, United States

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