New combo therapy offers hope for patients with resistant stomach cancer

NCT ID NCT06208748

First seen Oct 31, 2025 · Last updated May 15, 2026 · Updated 28 times

Summary

This study tests a new drug combination (bezuclastinib plus sunitinib) in 40 adults with advanced gastrointestinal stromal tumors (GIST) that worsened despite sunitinib treatment. The goal is to see if the combination can delay cancer growth. Participants take both drugs by mouth, and researchers monitor tumor changes and genetic markers.

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Contacts and locations

Locations

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvania, 19111, United States

  • Oregon Health & Science University

    Portland, Oregon, 97239, United States

  • Sylvester Comprehensive Cancer Center, University of Miami

    Miami, Florida, 33136, United States

Conditions

Explore the condition pages connected to this study.