Glowing dye could help surgeons avoid cutting nerves
NCT ID NCT05377554
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This trial tested a dye called bevonescein that makes nerves glow under special light during surgery. 154 people having head or neck surgery received the dye before their operation. Surgeons then compared standard white light with the glowing view to see if nerves were easier to spot. The goal is to help surgeons avoid accidentally damaging nerves.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
bevonescein (ALM-488)
What this could lead to
If successful, this could give surgeons a real-time way to see nerves during surgery, potentially reducing accidental nerve injury.
What could go wrong
This is a completed Phase 3 trial, but results are not yet published. The dye may not improve outcomes enough to change practice, and there may be unknown side effects.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Alume Biosciences
La Jolla, California, 92097, United States