New DNA test catches UTIs that standard cultures miss

NCT ID NCT05206500

Recruiting now Diagnosis Sponsor: Wake Forest University Health Sciences Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether next-generation sequencing (NGS), a DNA-based method, can detect bacteria in urine when standard lab cultures show very low or no growth. About 100 women with UTI symptoms but inconclusive standard tests will provide urine samples for NGS analysis. The goal is to see if NGS can identify hidden infections and guide more effective antibiotic treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Next Generation Sequencing (NGS) device
What this could lead to: If successful, this could lead to more accurate diagnosis of urinary tract infections in patients whose standard tests are inconclusive.
What could go wrong: This is a small, early-phase study (100 participants) and NGS may not always translate into better treatment outcomes. The approach is still experimental.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

urinary tract infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

URINARY TRACT INFECTIONS

Contacts and locations

Locations

Wake Forest Health Sciences
RECRUITING

Winston-Salem, North Carolina, 27157, United States

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