Could a common heart drug spark new muscle growth in babies with heart defects?

NCT ID NCT04713657

Recruiting now Disease control Sponsor: Weill Medical College of Cornell University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tests whether the beta-blocker propranolol can stimulate heart muscle cell growth in infants born with Tetralogy of Fallot, a serious heart defect. Forty infants under 60 days old will receive propranolol, and researchers will measure new heart muscle cells in tissue discarded during surgery. The goal is to see if this approach could eventually prevent heart failure later in life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Propranolol (a beta-blocker medicine)
What this could lead to: If it works, this could point toward a treatment that helps infants with congenital heart disease grow new heart muscle cells, potentially reducing their risk of heart failure later in life.
What could go wrong: This is a very early Phase 1 trial with only 40 infants, so it is not yet known if propranolol is effective or safe for this purpose. The study is small and exploratory, so results may not lead to a proven therapy.

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Conditions

The condition(s) this trial relates to.

double outlet right ventricle tetralogy of fallot

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DOUBLE OUTLET RIGHT VENTRICLE TETRALOGY OF FALLOT

Contacts and locations

Locations

Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Upmc Children'S Hospital of Pittsburgh
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
Weill Cornell Medicine
RECRUITING

New York, New York, 10065, United States

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