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Old drug showdown: can benzhexol match procyclidine for Parkinson's tremor?

NCT ID NCT07810296

Symptom relief Sponsor: safia bano Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 09, 2026 · Last updated Sep 15, 2026 · Updated 3 times

Summary

Researchers are comparing two anticholinergic medicines, benzhexol and procyclidine, to see whether they ease tremor similarly in adults with tremor-predominant Parkinson's disease. About 88 people aged 40 to 70 who already take levodopa will be randomly assigned to add one of the two drugs to their usual treatment. The team will track tremor scores and side effects before treatment and at 2 weeks, 3 months, and 6 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
benzhexol and procyclidine, two older oral anticholinergic medicines
What this could lead to
If benzhexol works about as well as procyclidine, doctors could have another option for easing Parkinson's tremor, and possibly one that is cheaper or easier to get.
What could go wrong
This is a small, single-country comparison of two drugs that have been used for decades, so it may not change practice. Both medicines can cause memory trouble, confusion, dry mouth, and urinary problems, especially in older adults.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 88 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosed Parkinson's disease according to the Movement Disorder Society Clinical Diagnostic Criteria for Parkinson's Disease, with predominant tremor at presentation. * Hoehn and Yahr stage 1, 2, or 3. * Any gender. * Age 40 to 70 years. * Receiving levodopa/carbidopa monotherapy for Parkinson's disease, with resting tremor present. Exclusion Criteria: * Cognitive or behavioral abnormalities. * Lower urinary tract symptoms. * Benign prostatic hyperplasia. * Angle-closure glaucoma. * Cardiac disease.

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Conditions

The condition(s) this trial relates to.

Parkinson disease Tremor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Parkinson disease (PD)

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Mayo Hospital Lahore

    RECRUITING

    Lahore, Punjab Province, 54000, Pakistan

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