Promising drug may tame rare blood disorder flares
NCT ID NCT04191304
First seen Jan 06, 2026 · Last updated May 06, 2026 · Updated 25 times
Summary
This study tests whether the drug benralizumab can prevent or delay flare-ups in people with hypereosinophilic syndrome (HES), a rare condition where too many eosinophils (a type of white blood cell) cause damage to organs. About 134 participants aged 12 and older will receive either benralizumab or a placebo every 4 weeks for 24 weeks, alongside their usual treatments. After that, everyone can receive benralizumab in an open-label extension. The main goal is to see if the drug reduces the time to the first HES flare.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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La Jolla, California, 92037, United States
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Atlanta, Georgia, 30324, United States
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Bethesda, Maryland, 20892, United States
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Ann Arbor, Michigan, 48105, United States
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Durham, North Carolina, 27705, United States
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Cleveland, Ohio, 44106, United States
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Columbus, Ohio, 43212, United States
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Salt Lake City, Utah, 84112, United States
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Rosario, 2000, Argentina
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Innsbruck, 6020, Austria
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Brussels, 1070, Belgium
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Edegem, 2650, Belgium
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Chengdu, 610041, China
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Tianjin, 300020, China
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Xiamen, 361015, China
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Zhengzhou, 450008, China
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København Ø, 2100, Denmark
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Lille, 59037, France
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Pessac, 33604, France
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Strasbourg, 67091, France
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Suresnes, 92151, France
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Toulouse, 31059, France
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Hanover, 30625, Germany
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Kirchheim, 73230, Germany
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Mannheim, 68167, Germany
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Ahmedabad, 380013, India
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Ajmer, 305001, India
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Delhi, 110029, India
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Haifa, 34362, Israel
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Holon, 58100, Israel
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Jerusalem, 91120, Israel
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Kfar Saba, 44218, Israel
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Petah Tikva, 49100, Israel
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Ramat Gan, 5265601, Israel
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Rehovot, 76100, Israel
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Tel Aviv, 64239, Israel
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Bologna, 40138, Italy
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Chiba, 260-0852, Japan
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Hamamatsu, 431-3192, Japan
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Ichikawa-shi, 272-8516, Japan
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Kawasaki-shi, 211-8510, Japan
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Nishinomiya-shi, 663-8501, Japan
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Osaka, 530-8480, Japan
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Sendai, 980-8574, Japan
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Rotterdam, 3015 GD, Netherlands
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Chęciny, 26-060, Poland
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Gdansk, 80-214, Poland
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Lodz, 90-153, Poland
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Seoul, 5505, South Korea
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Santander, 39010, Spain
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London, W2 1NY, United Kingdom
Conditions
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