New pill targets multiple rare cancers in major trial

NCT ID NCT04924075

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

Summary

This study is testing an oral medication called belzutifan for people with advanced rare tumors, including pheochromocytoma, pancreatic neuroendocrine tumors, VHL disease-associated tumors, and certain gastrointestinal cancers. The main goal is to see how well the drug shrinks tumors and how safe it is for participants. Researchers are enrolling 322 people aged 12 and older who have one of these specific rare tumor types.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Addenbrooke's Hospital ( Site 1309)
RECRUITING

Cambridge, Cambridgeshire, CB2 2QQ, United Kingdom

Contact Phone: •••-•••-••••
Akademiska sjukhuset-Blod- och tumörsjukdomar ( Site 1201)
RECRUITING

Uppsala, Uppsala County, 751 85, Sweden

Contact Phone: •••-•••-••••
Ankara Bilkent Şehir Hastanesi. ( Site 0904)
RECRUITING

Ankara, 06800, Turkey (Türkiye)

Contact Phone: •••-•••-••••
Arthur J.E. Child Comprehensive Cancer Centre ( Site 0203)
RECRUITING

Calgary, Alberta, T2N 5G2, Canada

Contact Phone: •••-•••-••••
Asan Medical Center ( Site 2000)
RECRUITING

Songpa-gu, Seoul, 05505, South Korea

Contact Phone: •••-•••-••••
Azienda Ospedaliera Spedali Civili di Brescia-Oncology ( Site 0701)
RECRUITING

Brescia, 25123, Italy

Contact Phone: •••-•••-••••
Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Roma ( Site 0703)
RECRUITING

Verona, 37134, Italy

Contact Phone: •••-•••-••••
Azienda Ospedaliero Universitaria Senese-U.O.C. Immunoterapia Oncologica ( Site 0706)
RECRUITING

Siena, Tuscany, 53100, Italy

Contact Phone: •••-•••-••••
Baskent University Adana Training Hospital ( Site 0906)
RECRUITING

Yüreğir, Adana, 01250, Turkey (Türkiye)

Contact Phone: •••-•••-••••
CHU Strasbourg-Hautepierre-Medecine Interne, Endocrinologie et Nutrition ( Site 0402)
RECRUITING

Strasbourg, Alsace, 67098, France

Contact Phone: •••-•••-••••
Cedars-Sinai Medical Center ( Site 0110)
RECRUITING

Los Angeles, California, 90048, United States

Contact Phone: •••-•••-••••
Centro de Oncología de Precisión ( Site 2203)
RECRUITING

Santiago, Region M. de Santiago, 7560908, Chile

Contact Phone: •••-•••-••••
Charité Universitaetsmedizin Berlin - Campus Mitte-Department of Endocrinology and Metabolism ( Site 0503)
RECRUITING

Berlin, 10117, Germany

Contact Phone: •••-•••-••••
Comprehensive Cancer Center Mainfranken-Div. of Endocrinology and Diabetes ( Site 0500)
RECRUITING

Würzburg, Bavaria, 97080, Germany

Contact Phone: •••-•••-••••
Ege University Medicine of Faculty ( Site 0900)
RECRUITING

Bornova, İzmir, 35100, Turkey (Türkiye)

Contact Phone: •••-•••-••••
Endocrinology Research Center of Rosmedtechnologies-Surgery ( Site 0809)
COMPLETED

Moscow, Moscow, 117036, Russia
FALP ( Site 2200)
RECRUITING

Santiago, Region M. de Santiago, 7500921, Chile

Contact Phone: •••-•••-••••
Fed State Budgetary Inst N.N. Blokhin Med Center of Oncology MHRF ( Site 0801)
RECRUITING

Moscow, Moscow, 115522, Russia

Contact Phone: •••-•••-••••
Fondazione IRCCS Istituto Nazionale dei Tumori-S.C. Oncologia Medica 2- Sarcomi ( Site 0709)
RECRUITING

Milan, Lombardy, 20133, Italy

Contact Phone: •••-•••-••••
GBUZ Republican Clinical Oncological Dispensary ( Site 0804)
COMPLETED

Ufa, Baskortostan, Respublika, 450054, Russia
Gustave Roussy ( Site 0403)
RECRUITING

Villejuif, Île-de-France Region, 94805, France

Contact Phone: •••-•••-••••
Hacettepe Universitesi-oncology hospital ( Site 0901)
RECRUITING

Ankara, 06230, Turkey (Türkiye)

Contact Phone: •••-•••-••••
Hammersmith Hospital-Medical Oncology ( Site 1304)
RECRUITING

London, London, City of, W12 OHS, United Kingdom

Contact Phone: •••-•••-••••
Hokkaido University Hospital ( Site 1800)
ACTIVE_NOT_RECRUITING

Sapporo, Hokkaido, 060-8648, Japan
Hopitaux Universitaires Paris Centre-Hopital Cochin ( Site 0404)
RECRUITING

Paris, 75014, France

Contact Phone: •••-•••-••••
Hospital Universitari Vall d'Hebron ( Site 1100)
RECRUITING

Barcelona, 08035, Spain

Contact Phone: •••-•••-••••
Hospital Universitario 12 de Octubre-Medical Oncology ( Site 1103)
RECRUITING

Madrid, Madrid, Comunidad de, 28041, Spain

Contact Phone: •••-•••-••••
Hospital Universitario Central de Asturias-Medical Oncology ( Site 1101)
RECRUITING

Oviedo, Principality of Asturias, 33011, Spain

Contact Phone: •••-•••-••••
Hôpital Edouard Herriot-oncologie ( Site 0405)
RECRUITING

Lyon, Auvergne-Rhône-Alpes, 69003, France

Contact Phone: •••-•••-••••
Hôpitaux Universitaires Paris Sud - Hôpital Bicêtre ( Site 0407)
RECRUITING

Le Kremlin-Bicêtre, Paris, 94270, France

Contact Phone: •••-•••-••••
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola ( Site 0708)
RECRUITING

Bologna, 40138, Italy

Contact Phone: •••-•••-••••
Icahn School of Medicine at Mount Sinai ( Site 0123)
ACTIVE_NOT_RECRUITING

New York, New York, 10029, United States
Institut Paoli-Calmettes-Oncology ( Site 0406)
COMPLETED

Marseille, Bouches-du-Rhone, 13009, France
Instituto Portugues de Oncologia Do Porto Francisco Gentil E.P.E. ( Site 2600)
RECRUITING

Porto, 4200-072, Portugal

Contact Phone: •••-•••-••••
Istanbul Universitesi Cerrahpasa-Medical Oncology ( Site 0902)
COMPLETED

Istanbul, 34668, Turkey (Türkiye)
Istituto Europeo di Oncologia IRCCS-Divisione di Oncologia Medica Gastrointestinale e Tumori Neuroe ( Site 0700)
RECRUITING

Milan, 20141, Italy

Contact Phone: •••-•••-••••
Johns Hopkins Hospital-Sidney Kimmel Comprehensive Cancer Center - Developmental Therapeutics ( Site 0108)
RECRUITING

Baltimore, Maryland, 21287, United States

Contact Phone: •••-•••-••••
Karolinska Universitetssjukhuset Solna ( Site 1202)
COMPLETED

Stockholm, Stockholm County, 171 76, Sweden
Klinikum der Ludwig-Maximilians-Universitaet Muenchen-Department of Internal Medicine IV, Division ( Site 0501)
COMPLETED

München, Bavaria, 80336, Germany
Kochi Medical School Hospital ( Site 1807)
ACTIVE_NOT_RECRUITING

Nankoku, Kochi, 783-8505, Japan
Kyoto University Hospital ( Site 1806)
ACTIVE_NOT_RECRUITING

Kyoto, 606-8507, Japan
MD Anderson Cancer Center-Oncology ( Site 1102)
COMPLETED

Madrid, Madrid, Comunidad de, 28033, Spain
Massachusetts General Hospital ( Site 0111)
RECRUITING

Boston, Massachusetts, 02114, United States

Contact Phone: •••-•••-••••
National Cancer Center Hospital ( Site 1802)
ACTIVE_NOT_RECRUITING

Chuo-ku, Tokyo, 104-0045, Japan
National Cancer Centre Singapore ( Site 1700)
RECRUITING

Singapore, Central Singapore, 168583, Singapore

Contact Phone: •••-•••-••••
National Institutes of Health ( Site 0125)
RECRUITING

Bethesda, Maryland, 20892, United States

Contact Phone: •••-•••-••••
Northwestern Medicine Cancer Center - Warrenville ( Site 0134)
RECRUITING

Warrenville, Illinois, 60555, United States

Contact Phone: •••-•••-••••
Northwestern University - Robert H. Lurie Comprehensive Cancer Center ( Site 0130)
RECRUITING

Chicago, Illinois, 60611, United States

Contact Phone: •••-•••-••••
Odense Universitetshospital ( Site 0302)
RECRUITING

Odense, Region Syddanmark, 5000, Denmark

Contact Phone: •••-•••-••••
Oslo Universitetssykehus Radiumhospitalet ( Site 2400)
RECRUITING

Oslo, 0424, Norway

Contact Phone: •••-•••-••••
Ospedale San Raffaele-Oncologia Medica ( Site 0705)
COMPLETED

Milan, 20132, Italy
Peking University First Hospital-Urology ( Site 1900)
ACTIVE_NOT_RECRUITING

Beijing, Beijing Municipality, 100034, China
Penn Medicine: University of Pennsylvania Health System-Heme/Onc ( Site 0127)
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

Contact Phone: •••-•••-••••
Prince of Wales Hospital-Medical Oncology ( Site 1601)
RECRUITING

Randwick, New South Wales, 2031, Australia

Contact Phone: •••-•••-••••
Princess Margaret Cancer Centre ( Site 0202)
RECRUITING

Toronto, Ontario, M5G 2M9, Canada

Contact Phone: •••-•••-••••
Renji Hospital Shanghai Jiao Tong University School of Medicine ( Site 1904)
ACTIVE_NOT_RECRUITING

Shanghai, Shanghai Municipality, 200001, China
Rigshospitalet ( Site 0304)
RECRUITING

Copenhagen, Capital Region, 2100, Denmark

Contact Phone: •••-•••-••••
Rigshospitalet-Department of Endocrinology ( Site 0303)
RECRUITING

Copenhagen, Capital Region, 2100, Denmark

Contact Phone: •••-•••-••••
Royal Free Hospital ( Site 1302)
RECRUITING

London, England, NW3 2QG, United Kingdom

Contact Phone: •••-•••-••••
SCRI Oncology Partners ( Site 7000)
RECRUITING

Nashville, Tennessee, 37203, United States

Contact Phone: •••-•••-••••
START Lisbon - Hospital de Santa Maria ( Site 2601)
RECRUITING

Lisbon, Lisbon District, 1649-035, Portugal

Contact Phone: •••-•••-••••
Sahlgrenska Universitetssjukhuset-Department of Oncology CTU Clinical Trial Unit ( Site 1204)
RECRUITING

Gothenburg, Västra Götaland County, 413 45, Sweden

Contact Phone: •••-•••-••••
Saint Petersburg State University-Clinic of advanced medical technologies n. a. Nicolay I. Pirogov ( Site 0805)
COMPLETED

Saint Petersburg, Leningradskaya Oblast', 190020, Russia
Saint-Petersburg City Clinical Oncology Dispensary-Department of chemotherapy ( Site 0803)
RECRUITING

Saint Petersburg, Leningradskaya Oblast', 198255, Russia

Contact Phone: •••-•••-••••
Semmelweis University-Belgyógyászati és Onkológiai Klinika Hematológia Osztály ( Site 0600)
RECRUITING

Budapest, 1083, Hungary

Contact Phone: •••-•••-••••
Seoul National University Hospital ( Site 2001)
RECRUITING

Jongno-gu, Seoul, 03080, South Korea

Contact Phone: •••-•••-••••
Sheba Medical Center-Institute of Endocrinology, Diabetes and Metabolism ( Site 1400)
RECRUITING

Ramat Gan, 5262100, Israel

Contact Phone: •••-•••-••••
Skanes University Hospital Lund ( Site 1200)
RECRUITING

Lund, Skåne County, 221 85, Sweden

Contact Phone: •••-•••-••••
Sourasky Medical Center ( Site 1401)
RECRUITING

Tel Aviv, 6423906, Israel

Contact Phone: •••-•••-••••
Sun Yat-sen University Cancer Center ( Site 1905)
RECRUITING

Guangzhou, Guangdong, 510700, China

Contact Phone: •••-•••-••••
The Beatson West of Scotland Cancer Centre ( Site 1308)
RECRUITING

Glasgow, Glasgow City, G12 0YN, United Kingdom

Contact Phone: •••-•••-••••
The Royal Melbourne Hospital ( Site 1602)
RECRUITING

Parkville, Victoria, 3050, Australia

Contact Phone: •••-•••-••••
Tokyo Women's Medical University Adachi Medical Center ( Site 1803)
ACTIVE_NOT_RECRUITING

Tokyo, 123-8558, Japan
Universitaetsklinikum Duesseldorf-Gastroenterology, Hepatology and Infectiology ( Site 0505)
RECRUITING

Düsseldorf, North Rhine-Westphalia, 40225, Germany

Contact Phone: •••-•••-••••
Universitaetsklinikum Freiburg ( Site 0504)
RECRUITING

Freiburg, Brandenburg, 79106, Germany

Contact Phone: •••-•••-••••
Universitair Medisch Centrum Utrecht ( Site 1530)
RECRUITING

Utrecht, 3584 CX, Netherlands

Contact Phone: •••-•••-••••
University of Iowa ( Site 0104)
RECRUITING

Iowa City, Iowa, 52242, United States

Contact Phone: •••-•••-••••
University of Michigan ( Site 0126)
RECRUITING

Ann Arbor, Michigan, 48109, United States

Contact Phone: •••-•••-••••
University of Naples Federico II-Dipartimento di Medicina Clinica e Chirurgia ( Site 0704)
COMPLETED

Naples, Campania, 80100, Italy
University of Texas MD Anderson Cancer Center ( Site 0112)
RECRUITING

Houston, Texas, 77030, United States

Contact Phone: •••-•••-••••
Vanderbilt University Medical Center ( Site 0107)
RECRUITING

Nashville, Tennessee, 37232, United States

Contact Phone: •••-•••-••••
Washington University-Internal Medicine/Oncology ( Site 0124)
ACTIVE_NOT_RECRUITING

St Louis, Missouri, 63110, United States
West China Hospital of Sichuan University ( Site 1906)
COMPLETED

Chengdu, Sichuan, 610041, China
Yokohama City University Hospital ( Site 1804)
ACTIVE_NOT_RECRUITING

Yokohama, Kanagawa, 236-0004, Japan

Conditions

Explore the condition pages connected to this study.

ADVANCED GASTROINTESTINAL STROMAL TUMOR HIF-2Α MUTATED CANCERS PANCREATIC NEUROENDOCRINE TUMOR PHEOCHROMOCYTOMA/PARAGANGLIOMA VON HIPPEL-LINDAU DISEASE