New hope for tough-to-treat melanoma: drug combo targets NRAS mutation
NCT ID NCT04835805
First seen Nov 01, 2025 · Last updated May 07, 2026 · Updated 29 times
Summary
This early-phase study tests a new drug called belvarafenib, alone or with other drugs (cobimetinib and nivolumab), in people with advanced melanoma that has a specific gene change (NRAS mutation) and has stopped responding to standard immunotherapy. The main goals are to check safety and find the right dose. About 65 adults with stage 3 or 4 melanoma that has worsened after anti-PD-1/PD-L1 treatment are taking part.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Asan Medical Center - PPDS
Seoul, 05505, South Korea
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California Pacific Medical Center Research Institute
San Francisco, California, 94115, United States
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Calvary Mater Newcastle
Waratah, New South Wales, 2298, Australia
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Charité - Universitätsmedizin Berlin
Berlin, 12203, Germany
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Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
Baltimore, Maryland, 21231, United States
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Klinikum Mannheim GmbH Universitätsklinikum
Mannheim, 68167, Germany
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Linear Clinical Research Ltd
Nedlands, Western Australia, 6009, Australia
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Memorial Sloan Kettering
New York, New York, 10021, United States
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Ottawa Hospital Regional Cancer Centre
Ottawa, Ontario, K1H 8M2, Canada
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Peter MacCallum Cancer Centre-East Melbourne
Melbourne, Victoria, 3000, Australia
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Princess Margaret Hospital
Toronto, Ontario, M5G 2M9, Canada
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UCSF Helen Diller Family CCC
San Francisco, California, 94158, United States
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Universitatsklinikum Tubingen
Tübingen, 72076, Germany
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University of Colorado Cancer Center
Aurora, Colorado, 80045, United States
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Universitätsklinikum Hamburg-Eppendorf
Hamburg, 20246, Germany
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Universitätsklinikum Würzburg
Würzburg, 97080, Germany
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
Conditions
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