New pill aims to keep HER2 lung cancer from returning after surgery

NCT ID NCT07195695

Recruiting now Disease control Sponsor: Boehringer Ingelheim Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 5 times

Summary

This study tests whether a daily pill called zongertinib can help prevent lung cancer from coming back in people with early-stage (Stage II-IIIB) non-small cell lung cancer that has a specific HER2 mutation. All participants have had surgery to remove their tumor and standard chemotherapy. Half will receive zongertinib, and the other half will receive standard care (either immunotherapy or active monitoring). The main goal is to see if zongertinib extends the time before the cancer returns.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

A.C. Camargo
RECRUITING

São Paulo, 01509-010, Brazil
AOU San Luigi Gonzaga
NOT_YET_RECRUITING

Orbassano (TO), 10043, Italy
Affiliated Hospital, Xuzhou Medical college
RECRUITING

Xuzhou, 221009, China
Aichi Cancer Center Hospital
RECRUITING

Aichi, Nagoya, 464-8681, Japan
Ajou University Hospital
RECRUITING

Suwon, 16499, South Korea
Asan Medical Center
RECRUITING

Seoul, 5505, South Korea
Asklepios Fachkliniken München-Gauting
NOT_YET_RECRUITING

Gauting, 82131, Germany
Austin Health
RECRUITING

Heidelberg, Victoria, 3084, Australia
Azienda Ospedaliera Universitaria Integrata Verona
RECRUITING

Verona, 37126, Italy
Beijing Chest Hospital, Capital Medical University
RECRUITING

Beijing, 101149, China
Bradford Hill- Centro de Investigación Clínica
RECRUITING

Recoleta, 8420383, Chile
CEPHO - Centro de Estudos e Pesquisas em Hematologia e Oncologia
RECRUITING

Santo André, 09060-650, Brazil
Cancer Care Specialists
RECRUITING

Reno, Nevada, 89511, United States
Centre Hospitalier Universitaire de Liège
NOT_YET_RECRUITING

Liège, 4000, Belgium
Centre Régional de Lutte Contre le Cancer Paul Stauss
RECRUITING

Strasbourg, 67200, France
Centro Gaúcho Integrado de Oncologia, Hematologia, Ensino e Pesquisa
RECRUITING

Porto Alegre, 90110-270, Brazil
Centro Medico Zambrano Hellion
NOT_YET_RECRUITING

Monterrey, 66278, Mexico
Centro Oncologico Internacional
NOT_YET_RECRUITING

Jalisco, 45640, Mexico
Centro Oncologico Korben
RECRUITING

CABA, 1426, Argentina
Centro Oncologico Personalizado
NOT_YET_RECRUITING

México, 6760, Mexico
Centro de Estudios Clinicos SAGA
RECRUITING

Providencia, 7500653, Chile
Centro de Infusion Profesional Integral (CIPI)
NOT_YET_RECRUITING

Mexico City, 14210, Mexico
Centro de Investigaciones Médicas y Desarrollo LC S.R.L. (LC Investigación)
RECRUITING

CABA, 1185, Argentina
Centro de Pesquisa Oncology Natal
RECRUITING

Natal, 59020-400, Brazil
Chang Gung Memorial Hospital, Linkou
RECRUITING

Taoyuan City, 333, Taiwan
Charité - Universitätsmedizin Berlin
NOT_YET_RECRUITING

Berlin, 12203, Germany
Chest Hospital of Athens "Sotiria"
NOT_YET_RECRUITING

Athens, 11527, Greece
China Medical University Hospital
RECRUITING

Taichung, 40447, Taiwan
China-Japan Friendship Hospital
RECRUITING

Beijing, 100029, China
ClinRé 001-022 (Premier Cancer Care and Infusion Center)
RECRUITING

Fresno, California, 93710, United States
Clinic Floridsdorf
RECRUITING

Vienna, 1210, Austria
Clinica Adventista Belgrano
RECRUITING

CABA, 1430, Argentina
Community Cancer Trials of Utah
RECRUITING

Ogden, Utah, 84405, United States
Complejo Hospitalario de Navarra
RECRUITING

Pamplona, 31008, Spain
Cross Cancer Institute (University of Alberta)
NOT_YET_RECRUITING

Edmonton, Alberta, T6G 1Z2, Canada
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Duly Health and Care - Lisle
RECRUITING

Lisle, Illinois, 60532, United States
Durham VA Health Care System
NOT_YET_RECRUITING

Durham, North Carolina, 27705, United States
Edegem - UNIV UZ Antwerpen
RECRUITING

Edegem, 2650, Belgium
Flinders Medical Centre
NOT_YET_RECRUITING

Bedford Park, South Australia, 5042, Australia
Fondazione IRCCS Istituto Nazionale dei Tumori
RECRUITING

Milan, 20133, Italy
Fujita Health University Hospital
RECRUITING

Aichi, Toyoake, 470-1192, Japan
Fundación Jiménez Díaz
RECRUITING

Madrid, 28040, Spain
George Washington University Cancer Center
NOT_YET_RECRUITING

Washington D.C., District of Columbia, 20037, United States
Guy's Hospital
RECRUITING

London, SE1 9RT, United Kingdom
HOP Nord
RECRUITING

Marseille, 13915, France
HOP Nord Laennec
RECRUITING

Nantes, 44093, France
HOP Pontchaillou
RECRUITING

Rennes, 35033, France
HOP Tenon - One AP-HP
RECRUITING

Paris, 75970, France
Harbin Medical University Cancer Hospital
RECRUITING

Harbin, 150081, China
Hebei Provincial Tumor Hospital
NOT_YET_RECRUITING

Shijiazhuang, 50035, China
Henan Cancer Hospital
NOT_YET_RECRUITING

Zhengzhou, 450008, China
Hendrick Health
RECRUITING

Abilene, Texas, 79601, United States
Henry Dunant Hospital, Athens
NOT_YET_RECRUITING

Athens, 11526, Greece
Hiroshima University Hospital
RECRUITING

Hiroshima, Hiroshima, 734-8551, Japan
Hokkaido Cancer Center
RECRUITING

Hokkaido, Sapporo, 003-0804, Japan
Hospital Britanico de Buenos Aires
RECRUITING

CABA, 1280AEB, Argentina
Hospital CUF Porto
RECRUITING

Porto, 4100-180, Portugal
Hospital CUF Tejo
RECRUITING

Lisbon, 1350-352, Portugal
Hospital Clinico Universitario de Valencia
RECRUITING

Valencia, 46010, Spain
Hospital Duran i Reynals
RECRUITING

L'Hospitalet de Llobregat, 8908, Spain
Hospital General Universitario de Elche
NOT_YET_RECRUITING

Elche, 3203, Spain
Hospital Jerez de la Frontera
RECRUITING

Jerez de la Frontera, 11407, Spain
Hospital Puerta de Hierro
RECRUITING

Majadahonda, 28222, Spain
Hospital Universitari Vall D Hebron
RECRUITING

Barcelona, 8035, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitario De Burgos
RECRUITING

Burgos, 9006, Spain
Hospital Universitario Ramon Y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Universitario Virgen de la Victoria
RECRUITING

Málaga, 29010, Spain
Hospital Virgen del Rocío
RECRUITING

Seville, 41013, Spain
Hospital da Luz
RECRUITING

Lisbon, 1500-650, Portugal
Hospital de Amor
RECRUITING

Barretos, 14784-400, Brazil
Hospital del Mar
RECRUITING

Barcelona, 8003, Spain
Hospital of the University of Occupational and Environmental Health
RECRUITING

Fukuoka, Kitakyushu, 807-8556, Japan
Humanitas Istituto Clinico Catanese S.p.A.
NOT_YET_RECRUITING

Misterbianco (CT), 95045, Italy
Hunan Province Tumor Hospital
NOT_YET_RECRUITING

Changsha, 410013, China
Hôpital Larrey - CHU de Toulouse
RECRUITING

Toulouse, 31059, France
Hôpital Louis Pradel
RECRUITING

Bron, 69677, France
ICESP - Instituto do Cancer do Estado de Sao Paulo
NOT_YET_RECRUITING

São Paulo, 01246-000, Brazil
IPO Porto Francisco Gentil, EPE
NOT_YET_RECRUITING

Porto, 4200-072, Portugal
Institut Gustave Roussy
RECRUITING

Villejuif, 94805, France
Instituto Medico Especializado Alexander Fleming
RECRUITING

Capital Federal, C1426ANZ, Argentina
Instituto Nacional de Cancerologia
NOT_YET_RECRUITING

México, 14080, Mexico
Istituti Fisioterapici Ospitalieri
RECRUITING

Roma, 144, Italy
Istituto Clinico Humanitas
RECRUITING

Rozzano (MI), 20089, Italy
Istituto Nazionale IRCCS Tumori Fondazione Pascale
RECRUITING

Naples, 80131, Italy
Istituto Tumori Giovanni Paolo II
RECRUITING

Bari, 70124, Italy
Japanese Foundation for Cancer Research
RECRUITING

Tokyo, Koto-ku, 135-8550, Japan
Jichi Medical University Hospital
RECRUITING

Tochigi, Shimotsuke, 329-0498, Japan
Juntendo University Hospital
RECRUITING

Tokyo, Bunkyo-ku, 113-8431, Japan
Kanagawa Cancer Center
RECRUITING

Kanagawa, Yokohama, 241-8515, Japan
Kansai Medical University Hospital
RECRUITING

Osaka, Hirakata, 573-1191, Japan
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung City, 807, Taiwan
Karolinska Universitetssjukhuset Solna
RECRUITING

Stockholm, 171 76, Sweden
Kindai University Hospital
RECRUITING

Osaka, Sakai, 590-0197, Japan
Kitasato University Hospital
RECRUITING

Kanagawa, Sagamihara, 252-0375, Japan
Klinikum Esslingen
RECRUITING

Esslingen am Neckar, 73730, Germany
Kyushu University Hospital
RECRUITING

Fukuoka, Fukuoka, 812-8582, Japan
Laura & Isaac Perlmutter Cancer Center at NYU Langone Health
RECRUITING

New York, New York, 10016, United States
Levine Cancer Institute
NOT_YET_RECRUITING

Charlotte, North Carolina, 28204, United States
Linyi Cancer Hospital
RECRUITING

Linyi, 276034, China
Lotus Med
RECRUITING

Bucharest, 12292, Romania
LungenClinic Grosshansdorf GmbH
RECRUITING

Großhansdorf, 22927, Germany
Medeniyet University
NOT_YET_RECRUITING

Istanbul, 34862, Turkey (Türkiye)
Medical University of Innsbruck
NOT_YET_RECRUITING

Innsbruck, A-6020, Austria
Meir Medical Center
NOT_YET_RECRUITING

Kfar Saba, 44281, Israel
Memorial Healthcare International
RECRUITING

Bucharest, 13823, Romania
Memorial Sloan-Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Mid Florida Hematology and Oncology Center
RECRUITING

Orange City, Florida, 32763, United States
Nanjing Drum Tower Hospital
RECRUITING

Nanjing, 210008, China
National Cancer Center
RECRUITING

Goyang, 10408, South Korea
National Cancer Center Hospital
RECRUITING

Tokyo, Chuo-ku, 104-0045, Japan
National Cancer Center Hospital East
NOT_YET_RECRUITING

Chiba, Kashiwa, 277-8577, Japan
National Cancer Centre Singapore
RECRUITING

Singapore, 168583, Singapore
National Hospital Organization Kinki-Chuo Chest Medical Center
RECRUITING

Osaka, Sakai, 591-8555, Japan
National Taiwan University Hospital
RECRUITING

Taipei, 10048, Taiwan
Nederlands Kanker Instituut - Antoni van Leeuwenhoek Amsterdam (METC AVL)
RECRUITING

Amsterdam, 1066CX, Netherlands
NewData Clinical Research - Maceió
RECRUITING

Maceió, 57020-360, Brazil
Niigata Cancer Center Hospital
RECRUITING

Niigata, Niigata, 951-8566, Japan
Ningbo Second Hospital
RECRUITING

Ningbo, 315010, China
Northern California Kaiser Permanente
NOT_YET_RECRUITING

Vallejo, California, 94589, United States
Northern Jiangsu People's Hospital
RECRUITING

Yangzhou, 225001, China
Northwest Georgia Oncology Centers
RECRUITING

Marietta, Georgia, 30060, United States
Northwestern University
NOT_YET_RECRUITING

Chicago, Illinois, 60611, United States
OPN Healthcare, Inc.
RECRUITING

Glendale, California, 91203, United States
Okayama University Hospital
RECRUITING

Okayama, Okayama, 700-8558, Japan
Osaka International Cancer Institute
RECRUITING

Osaka, Osaka, 541-8567, Japan
Ovidius Clinical Hospital S.R.L
RECRUITING

Ovidiu, 905900, Romania
Piedmont Cancer Institute
RECRUITING

Atlanta, Georgia, 30318, United States
Pius-Hospital, Oldenburg
RECRUITING

Oldenburg, 26121, Germany
Polaris Medical S.A.
NOT_YET_RECRUITING

Suceagu/ Cluj Napoca, 407062, Romania
Prince of Wales Hospital-Hong Kong-20715
RECRUITING

Hong Kong, 999077, Hong Kong
Princess Alexandra Hospital
NOT_YET_RECRUITING

Woolloongabba, Queensland, 4102, Australia
Princess Margaret Cancer Centre
NOT_YET_RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Princess Margaret Hospital
RECRUITING

Hong Kong, 999077, Hong Kong
Providence Cancer Institute
RECRUITING

Portland, Oregon, 97213, United States
Queen Elizabeth Hospital-Hong Kong-51727
RECRUITING

Hong Kong, 51727, Hong Kong
Queen Mary Hospital
RECRUITING

Hong Kong, Hong Kong
Rambam Health Care Campus
NOT_YET_RECRUITING

Haifa, 3109601, Israel
Royal North Shore Hospital
RECRUITING

Sydney, New South Wales, 2065, Australia
Sahlgrenska Universitetsjukhuset
RECRUITING

Gothenburg, 413 46, Sweden
Saint Alphonsus Regional Medical Center - Boise
NOT_YET_RECRUITING

Boise, Idaho, 83706, United States
Saitama Cancer Center
RECRUITING

Saitama, Kitaadachi-gun, 362-0806, Japan
Saitama Medical University International Medical Center
RECRUITING

Saitama, Hidaka, 350-1298, Japan
Salut Sant Joan de Reus
RECRUITING

Reus, 43204, Spain
Samsung Medical Center
RECRUITING

Seoul, 6351, South Korea
Sarcoma Oncology Center
RECRUITING

Santa Monica, California, 90403, United States
Sağlık Bilimleri Üniversitesi Gülhane Eğitim ve Araştırma Hastanesi
RECRUITING

Ankara, 6018, Turkey (Türkiye)
Sendai Kousei Hospital
RECRUITING

Miyagi, Sendai, 981-0914, Japan
Seoul National University Bundang Hospital
RECRUITING

Seongnam, 13620, South Korea
Seoul National University Hospital
RECRUITING

Seoul, 3080, South Korea
Severance Hospital
RECRUITING

Seoul, 3722, South Korea
Shaare Zedek Medical Center, Jerusalem 91031
NOT_YET_RECRUITING

Jerusalem, 9103102, Israel
Shandong Cancer Hospital
RECRUITING

Jinan, 250117, China
Shanghai East Hospital
RECRUITING

Shanghai, 200121, China
Shanghai Pulmonary Hospital
RECRUITING

Shanghai, 200433, China
Sheba Medical Center
NOT_YET_RECRUITING

Ramat Gan, 5262000, Israel
Shizuoka Cancer Center
RECRUITING

Shizuoka, Sunto-gun, 411-8777, Japan
Sichuan Cancer Hospital
RECRUITING

Chengdu, 610041, China
Sjællands Universitetshospital
NOT_YET_RECRUITING

Roskilde, 4000, Denmark
Sourasky Medical Center
NOT_YET_RECRUITING

Tel Aviv, 6093246, Israel
St John of God Subiaco Hospital
RECRUITING

Subiaco, Western Australia, 6008, Australia
Sutter Health
NOT_YET_RECRUITING

Roseville, California, 95661, United States
Taipei Veterans General Hospital
RECRUITING

Taipei, 11217, Taiwan
Taizhou Hospital of Zhejiang Province
RECRUITING

Taizhou, 317099, China
The Catholic University of Korea, St.Vincent's Hospital
RECRUITING

Suwon, 16247, South Korea
The Christie
RECRUITING

Manchester, M20 4BX, United Kingdom
The First Affiliated Hospital of Nanchang University
RECRUITING

Nanchang, 330006, China
The First Affiliated Hospital of Soochow University
RECRUITING

Suzhou, 215006, China
The First Affiliated Hospital, Zhejiang University
RECRUITING

Hangzhou, 310003, China
The First Affiliated Hospital,Sun Yat-sen University
RECRUITING

Guangzhou, 510080, China
The First Hospital of Jilin University
RECRUITING

Changchun, 130000, China
The Royal Marsden Hospital, Chelsea
RECRUITING

London, SW3 6JJ, United Kingdom
The Royal Marsden Hospital, Sutton
RECRUITING

Sutton, SM2 5PT, United Kingdom
The University of Texas MD Anderson Cancer Center
NOT_YET_RECRUITING

Houston, Texas, 77030, United States
Thoraxklinik-Heidelberg gGmbH am Universitätsklinikum Heidelberg
RECRUITING

Heidelberg, 69126, Germany
Tianjin Cancer Hospital
RECRUITING

Tianjin, 300060, China
Tianjin Medical University General Hospital
RECRUITING

Tianjin, 30052, China
Tokyo Medical University Hospital
RECRUITING

Tokyo, Shinjuku-ku, 160-0023, Japan
Tri-Service General Hospital
RECRUITING

Taipei, 114, Taiwan
UZ Leuven
RECRUITING

Leuven, 3000, Belgium
University General Hospital Attikon
NOT_YET_RECRUITING

Athens, 12462, Greece
University of California Irvine
NOT_YET_RECRUITING

Irvine, California, 92697, United States
University of California Los Angeles
RECRUITING

Santa Monica, California, 90404, United States
University of California San Francisco
RECRUITING

San Francisco, California, 94143, United States
University of Illinois Hospital and Health Sciences System
RECRUITING

Chicago, Illinois, 60612, United States
Universitätsklinikum Köln (AöR)
RECRUITING

Cologne, 50937, Germany
Universitätsklinikum Würzburg AÖR
RECRUITING

Würzburg, 97078, Germany
Varisano LungenZentrum (VLZ)
RECRUITING

Frankfurt, 65929, Germany
Velindre Cancer Centre
NOT_YET_RECRUITING

Cardiff, CF14 2TL, United Kingdom
Virginia Cancer Specialists, PC
RECRUITING

Fairfax, Virginia, 22031, United States
Wakayama Medical University Hospital
RECRUITING

Wakayama, Wakayama, 641-8510, Japan
West China Hospital, Sichuan University
RECRUITING

Chengdu, 610041, China
Western General Hospital
RECRUITING

Edinburgh, EH4 2XU, United Kingdom
Wuhan Union Hospital
RECRUITING

Wuhan, 430056, China
Xiangya Hospital, Central South University
NOT_YET_RECRUITING

Changsha, 410008, China
Yunnan Provincial Tumor Hospital
RECRUITING

Kunming, 650118, China
Zhejiang Cancer Hospital
RECRUITING

Hangzhou, 310022, China

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