New drug trial hopes to tame rare skin disease

NCT ID NCT06539507

Recruiting now Disease control Sponsor: BioCryst Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial tests a new drug called BCX17725 in healthy volunteers and people with Netherton syndrome, a rare genetic skin condition. The study aims to check safety, how the drug moves through the body, and whether it can reduce skin redness and scaling. About 78 participants will take part across four parts, with the final part also looking at effectiveness over 12 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BCX17725
What this could lead to: If successful, this could point toward a treatment that controls the severe skin symptoms of Netherton syndrome.
What could go wrong: This is a very early Phase 1 trial, so safety and effectiveness are not yet known. The drug may not work or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Netherton syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NETHERTON SYNDROME

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Dawes Fretzin Clinical Research Group, LLC
RECRUITING

Indianapolis, Indiana, 46250, United States
Erasmus Universitair Medisch Centrum (EMC)
RECRUITING

Rotterdam, 3015 GD, Netherlands
Hôpital Saint-Louis
RECRUITING

Paris, 75010, France
Maastricht Universitair Medisch Centrum (MUMC+)
RECRUITING

Maastricht, 6229 HX, Netherlands
Northwestern Dermatology CTU
RECRUITING

Chicago, Illinois, 60611, United States
Nucleus Network
COMPLETED

Brisbane, Queensland, 4006, Australia
Stanford University School of Medicine
NOT_YET_RECRUITING

Palo Alto, California, 94304, United States
Therapeutics Clinical Research
RECRUITING

San Diego, California, 92123, United States
Universitätsklinikum Heidelberg
NOT_YET_RECRUITING

Heidelberg, 69120, Germany
Veracity Clinical Research
RECRUITING

Brisbane, Queensland, 4102, Australia

Contact Email: •••••@•••••
Westmead Hospital - Department of Dermatology
RECRUITING

Sydney, New South Wales, 2145, Australia
Yale Center for Clinical Investigation
RECRUITING

New Haven, Connecticut, 06519, United States

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