New targeted drug takes aim at Hard-to-Treat cancers

NCT ID NCT06914128

Recruiting now Disease control Sponsor: Bayer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug, BAY 3713372, for people with solid tumors that have a specific genetic deletion called MTAP. The drug is designed to kill cancer cells while sparing normal cells. The trial will first find a safe dose, then test how well it works in up to 450 participants.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

BAY 3713372 (a PRMT5 inhibitor)

What this could lead to

If successful, this could lead to a new targeted treatment option for people with MTAP-deleted solid tumors, potentially shrinking tumors or slowing their growth.

What could go wrong

This is an early first-in-human trial, so safety and effectiveness are not yet known. The drug may cause side effects or fail to work in many participants.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

glioblastoma non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MTAP-DELETED SOLID TUMORS

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Antwerp University Hospital | Oncology Department
RECRUITING

Antwerp, Antwerp, 2650, Belgium
Beijing Cancer Hospital - Oncology Department
RECRUITING

Beijing, Beijing Municipality, 100142, China
Calvary Mater Hospital Newcastle - Oncology
RECRUITING

Waratah, New South Wales, 2298, Australia
Centre Hospitalier Universitaire (CHU) de Liege - Domaine Universitaire du Sart Tilman - Medical Oncology
RECRUITING

Liège, 4000, Belgium
Centro di Riferimento Oncologico di Aviano - Oncologia Medica e dei Tumori Immuno-Correlati
NOT_YET_RECRUITING

Aviano, 33081, Italy
Chris O'Brien Lifehouse
RECRUITING

Camperdown, New South Wales, 2050, Australia
City of Hope - Duarte Cancer Center
NOT_YET_RECRUITING

Duarte, California, 91010, United States
Clinica Universidad De Navarra | Pamplona | Oncologia
NOT_YET_RECRUITING

Pamplona, Madrid, 31008, Spain
Concord Repatriation General Hospital (CRGH) (Concord Hospital) - Concord Cancer Centre
RECRUITING

Concord, New South Wales, 2139, Australia
Dana-Farber Cancer Institute - Oncology Department
NOT_YET_RECRUITING

Boston, Massachusetts, 02215, United States
Erasmus Medisch Centrum
NOT_YET_RECRUITING

Rotterdam, South Holland, 3015 CE, Netherlands
Fakultní nemocnice Olomouc - Onkologická klinika
RECRUITING

Olomouc, Olomouc Region, 779 00, Czechia
Fondazione IRCCS Istituto Nazionale dei Tumori - S. C. Oncologia Medica 1
RECRUITING

Milan, 20133, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOC Fase I
RECRUITING

Roma, 00128, Italy
Froedtert Hospital - Clinical Cancer Center
NOT_YET_RECRUITING

Milwaukee, Wisconsin, 53226, United States
Ghent University Hospital | Drug Research Unit Department
RECRUITING

Ghent, East Flanders, 9000, Belgium
Hospital Clinico Universitario De Valencia | Oncologia
NOT_YET_RECRUITING

Valencia, 46010, Spain
Hospital Hm Nou Delfos | Oncologia
RECRUITING

Barcelona, 08023, Spain
Hospital San Pedro | Oncologia
RECRUITING

Logroño, La Rioja, 26006, Spain
Hospital Universitari Vall D Hebron | Oncologia
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario Fundacion Jimenez Diaz | Oncologia
RECRUITING

Madrid, 28040, Spain
Hospital Universitario Virgen De La Victoria | Oncologia
RECRUITING

Málaga, 29010, Spain
Humanitas Mirasole S.p.A. - Oncologia Medica ed Ematologia
RECRUITING

Rozzano, 20089, Italy
I.F.O. Istituti Fisioterapici Ospitalieri - Sperimentazioni cliniche Fase 1 e Medicina di precisione
NOT_YET_RECRUITING

Roma, 00144, Italy
Icahn School of Medicine at Mount Sinai - Oncology
NOT_YET_RECRUITING

New York, New York, 10029, United States
Icon Cancer Centre
NOT_YET_RECRUITING

Singapore, 217562, Singapore
Karolinska Universitetssjukhuset - Solna - Fas I-enheten Solna CKC
RECRUITING

Stockholm, Stockholm County, 171 76, Sweden
Kindai University Hospital
NOT_YET_RECRUITING

Sakai, Osaka, 590-0197, Japan
Masarykova Univerzita - Masarykuv Onkologicky Ustav (MOU) - Klinika Komplexni Onkologicke Pece (KKOP)
RECRUITING

Brno, South Moravian, 602 00, Czechia
Massachusetts General Hospital - Neurology
NOT_YET_RECRUITING

Boston, Massachusetts, 02114, United States
Memorial Sloan Kettering Cancer Center New York - Main Campus
NOT_YET_RECRUITING

New York, New York, 10065, United States
NEXT - Hospital Universitario Quironsalud Madrid | Oncologia
RECRUITING

Pozuelo de Alarcón, Madrid, 28223, Spain
NEXT Dallas - Oncology Department
RECRUITING

Irving, Texas, 75039, United States
Nagoya University Hospital
NOT_YET_RECRUITING

Nagoya, Aichi-ken, 466-8560, Japan
National Cancer Center Hospital
RECRUITING

Chuo-ku, Tokyo, 104-0045, Japan
National Cancer Center Hospital East
NOT_YET_RECRUITING

Kashiwa, Chiba, 277-8577, Japan
National Cancer Center Singapore - Oncology Department
RECRUITING

Singapore, 168583, Singapore
National University Hospital Medical Centre
RECRUITING

Singapore, 119074, Singapore
Nederlands Kanker Instituut
RECRUITING

Amsterdam, North Holland, 1066 CX, Netherlands
Northern Hospital
SUSPENDED

Epping, New South Wales, 3076, Australia
Odense University Hospital | Svendborg Sygehus - Oncology Department
RECRUITING

Odense, Region Syddanmark, 5000, Denmark
Rigshospitalet Copenhagen University Hospital | Oncology Department
RECRUITING

Copenhagen, Capital Region, 2100, Denmark
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
START | Midwest
RECRUITING

Grand Rapids, Michigan, 49546, United States
START | San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
Sahlgrenska Universitetssjukhuset - Sahlgrenska Sjukhuset - Klinisk prövningsenhet Fas I/FIH
NOT_YET_RECRUITING

Gothenburg, Västra Götaland County, 413 46, Sweden
Sarah Cannon Research Institute at Florida Cancer Specialists- Lake Nona
RECRUITING

Orlando, Florida, 32827, United States
Sarah Cannon Research Institute at HCA HealthONE Presbyterian St. Luke's
RECRUITING

Denver, Colorado, 80218, United States
Shizuoka Cancer Center
RECRUITING

Sunto, Shizuoka, 411-8777, Japan
Stanford University Medical Center - Neurology
NOT_YET_RECRUITING

Stanford, California, 94305, United States
The Cancer Institute Hospital of JFCR
RECRUITING

Koto-ku, Tokyo, 135-8550, Japan
The Christie NHS Foundation Trust | Christie Hospital - Experimental Cancer Medicine Team
RECRUITING

Manchester, M20 5BX, United Kingdom
The Royal Marsden NHS Foundation Trust | Sutton - Oak Foundation Drug Development Unit
NOT_YET_RECRUITING

Sutton, Surrey, SM2 5PT, United Kingdom
Tongji Hosp. of Tongji Med Coll, Huazhong Uni of Sci & Tech.
RECRUITING

Wuhan, Hubei, 430075, China
UAB O'Neal Comprehensive Cancer Center - The Kirklin Clinic of UAB Hospital
NOT_YET_RECRUITING

Birmingham, Alabama, 35233, United States
UCHealth Cancer Center - Anschutz Medical Campus - University of Colorado Cancer Center
NOT_YET_RECRUITING

Aurora, Colorado, 80045, United States
UCLA Health Bowyer Oncology Center
NOT_YET_RECRUITING

Los Angeles, California, 90095, United States
UCSF Helen Diller Medical Center at Parnassus Heights - Neurology
NOT_YET_RECRUITING

San Francisco, California, 94143, United States
UZ Leuven Gasthuisberg - Pneumology Department
NOT_YET_RECRUITING

Leuven, Flemish Brabant, 3000, Belgium
Universitair Medisch Centrum Groningen (UMCG) - UMC Groningen Comprehensive Cancer Center
NOT_YET_RECRUITING

Groningen, 9713 GZ, Netherlands