New pill targets Hard-to-Treat cancers in early human trial

NCT ID NCT06973863

Recruiting now Disease control Sponsor: PharmaEngine Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase study is testing a new oral drug called PEP08 in up to 40 adults with advanced or metastatic solid tumors that have lost a gene called MTAP. The drug works by blocking a protein that cancer cells need to grow. The main goals are to check safety, find the right dose, and see if the drug shows any signs of shrinking tumors. The trial is currently recruiting for the first part, which tests PEP08 alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PEP08 (an oral drug that targets a protein called PRMT5, which helps cancer cells grow)
What this could lead to: If this early trial shows PEP08 is safe and shrinks tumors, it could point toward a new treatment option for people with certain hard-to-treat cancers that have an MTAP gene deletion.
What could go wrong: This is a very early Phase 1 trial with only 40 participants, so it is too soon to know if PEP08 will work or be safe. Many promising cancer drugs fail in early testing, and side effects are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMOR MTAP DELETION MTAP-DELETED SOLID TUMORS SOLID TUMORS

Contacts and locations

Locations

China Medical University Hospital
RECRUITING

Taichung, Taiwan
National Taiwan University Hospital
RECRUITING

Taipei, Taiwan
Taipei Veterans General Hospital
RECRUITING

Taipei, Taiwan
Westmead Hospital
RECRUITING

Wentworthville, New South Wales, 2145, Australia

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