New pill could lift depression without Long-Term side effects

NCT ID NCT07076407

Recruiting now Symptom relief Sponsor: Xenon Pharmaceuticals Inc. Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 21 times

Summary

This study tests a new drug called azetukalner for adults with moderate-to-severe major depression. About 450 people will receive either the drug or a placebo for 6 weeks. The goal is to see if the drug reduces depression symptoms and improves pleasure in daily life.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Activmed Practices & Research, Llc - Methuen
RECRUITING

Methuen, Massachusetts, 01844, United States
Adams Clinical Boston
RECRUITING

Boston, Massachusetts, 02116, United States
Adams Clinical Watertown
RECRUITING

Watertown, Massachusetts, 02472, United States
Advanced Quality Medical Research
RECRUITING

Orland Park, Illinois, 60462, United States
Artemis Institute for Clinical Research
RECRUITING

San Diego, California, 92103, United States
Austin Clinical Trial Partners
RECRUITING

Austin, Texas, 78737, United States
Bio Behavioral Health
RECRUITING

Toms River, New Jersey, 08755, United States
Bioscience Research, LLC
RECRUITING

Mount Kisco, New York, 10549, United States
Boeson Research
RECRUITING

Provo, Utah, 84604, United States
California Neuroscience Research
RECRUITING

Sherman Oaks, California, 91403, United States
Center for Neurohealth
RECRUITING

La Jolla, California, 93037, United States
Clinica Nutrimed Cercetare Sr
RECRUITING

Bucharest, 020744, Romania
Clinical Innovations Inc
RECRUITING

Bellflower, California, 90706, United States
Clinical Medical Research Sp. z o.o.
RECRUITING

Katowice, 40156, Poland
Delricht Research
RECRUITING

Atlanta, Georgia, 30329, United States
Emory University Brain Health Center
RECRUITING

Atlanta, Georgia, 30329, United States
Equipath Health and Research Tampa Bay, Llc
RECRUITING

Riverview, Florida, 33578, United States
Fieve Clinical Research, Inc.
RECRUITING

New York, New York, 10017, United States
Gulfcoast Clinical Research Center
RECRUITING

Fort Myers, Florida, 33912, United States
Harmonex Neuroscience Research
RECRUITING

Dothan, Alabama, 36303, United States
IMA Clinical Research
RECRUITING

New York, New York, 10128, United States
Insight Clinical Trials
RECRUITING

Independence, Ohio, 44195, United States
Institute of Living
RECRUITING

Hartford, Connecticut, 06106, United States
Liptovska Nemocnica S Poliklinikou Mudr. Ivana Stodolu Liptovsky Mikulas
RECRUITING

Liptovský Mikuláš, 03123, Slovakia
Lumina Clinical Research Center
RECRUITING

Cherry Hill, New Jersey, 08002, United States
Magnolia Clinical Research, Llc
RECRUITING

Cary, North Carolina, 27511, United States
Oulu Mentalcare Oy
RECRUITING

Oulu, 90100, Finland
Pacific Clinical Research Management Group
RECRUITING

Upland, California, 91786, United States
Pharmasite Research Inc.
RECRUITING

Baltimore, Maryland, 21208-6605, United States
Pillar Clinical Research
RECRUITING

Bentonville, Arkansas, 72712, United States
Praktyka Lekarska Malgorzata Wojtanowska-Bogacka
RECRUITING

Poznan, 60192, Poland
Princeton Medical Institute
RECRUITING

Princeton, New Jersey, 08540, United States
Psychiatric Care and Research Center
RECRUITING

O'Fallon, Missouri, 63368, United States
SanRo Clinical Research Group
RECRUITING

Bryant, Arkansas, 72022, United States
Sarkis Clinical Trials
RECRUITING

Gainesville, Florida, 32607, United States
Smart Trials, LLC
RECRUITING

Jefferson, Louisiana, 70121, United States
Sooner Clinical Research
RECRUITING

Oklahoma City, Oklahoma, 73116, United States
Specjalistyczna Praktyka Lekarska, Filip Rybakowski
RECRUITING

Poznan, 60744, Poland
St. Charles Psychiatric Associates - Midwest Research Group
RECRUITING

Saint Charles, Missouri, 63304, United States
Suomen Terveystalo Oy
RECRUITING

Helsinki, 00180, Finland
University of Alabama at Birmingham, Huntsville Regional Medical Campus
RECRUITING

Huntsville, Alabama, 35801, United States
Vitalix Clinical, Inc
RECRUITING

Worcester, Massachusetts, 01608, United States

Conditions

Explore the condition pages connected to this study.

MAJOR DEPRESSIVE DISORDER