New hope for tough blood cancers: experimental drug targets patients who failed first therapy

NCT ID NCT03770429

First seen Nov 01, 2025 · Last updated May 02, 2026 · Updated 22 times

Summary

This study tests an experimental drug called AZD6738 in adults with myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) whose disease got worse after standard frontline therapy. The main goal is to check the drug's safety and find the right dose. About 52 participants will take the drug and be monitored for side effects and how their cancer responds.

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Contacts and locations

Locations

  • BIDMC

    Boston, Massachusetts, 02215, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Massachusetts General Hospital Cancer Center

    Boston, Massachusetts, 02215, United States

  • Washington University

    St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.