Could a single dose of ayahuasca or esketamine ease PMS?
NCT ID NCT07317232
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares a single dose of ayahuasca or esketamine to see how they affect the menstrual cycle and premenstrual symptoms in 20 healthy women. Participants will track their symptoms using a questionnaire. The goal is to understand if these substances can influence PMS, but it is an early-stage, exploratory trial.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ayahuasca or esketamine
- What this could lead to
- If it works, this could point toward new ways to ease premenstrual symptoms.
- What could go wrong
- This is a very small, early study in healthy volunteers, so results may not apply to people with severe PMS or other conditions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Hospital das Clínicas da FMRP-USP
RECRUITINGRibeirão Preto, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••
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