New hope for rare ovarian cancer: drug combo targets tumor growth

NCT ID NCT06072781

Recruiting now Disease control Sponsor: Verastem, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 6 times

Summary

This study tests whether a combination of two drugs (avutometinib and defactinib) works better than standard treatments for people with recurrent low-grade serous ovarian cancer. About 270 participants whose cancer returned after platinum-based therapy will be randomly assigned to receive either the new combination or a standard treatment. The main goal is to see if the new combination delays cancer progression.

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Conditions

The condition(s) this trial relates to.

borderline ovarian serous tumor ovarian serous adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOW GRADE SEROUS OVARIAN CANCER

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

AO Cannizzaro
RECRUITING

Catania, 95126, Italy
Aalborg U.H
RECRUITING

Aalborg, 9000, Denmark
AdventHealth
RECRUITING

Orlando, Florida, 32804, United States
Agaplesion Markus Krankenhaus
RECRUITING

Frankfurt am Main, Hesse, 60431, Germany
Aichi Cancer Center Hospital
RECRUITING

Aichi, Nagoya, 464-8681, Japan
Allegheny Health Network
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Asplundh Cancer Pavilion | Jefferson Health
RECRUITING

Philadelphia, Pennsylvania, 19090, United States
Atrium Health
RECRUITING

Charlotte, North Carolina, 28203, United States
Auckland City Hospital
RECRUITING

Auckland, 1023, New Zealand
Białostockie Centrum Onkologii
RECRUITING

Bialystok, 15-027, Poland
British of Columbia
RECRUITING

Vancouver, V5Z 4E6, Canada
Cambridge University Hospital
RECRUITING

Cambridge, CB2 0QQ, United Kingdom
Cancer Research South Australia
RECRUITING

Adelaide, South Australia, 5000, Australia
Centre Hospitalier de Besançon
RECRUITING

Besançon, 25000, France
Centre Hospitalier de l'Universite de Montreal (CHUM)
RECRUITING

Montreal, Quebec, H2X 0C1, Canada
Centre Léon Bérard
RECRUITING

Lyon, 69373, France
Centre Oscar Lambret
RECRUITING

Lille, 59020, France
Centro di Riferimento Oncologico (CRO)
RECRUITING

Aviano, 33081, Italy
Charité - Universitätsmedizin Berlin
RECRUITING

Berlin, 13353, Germany
Cleveland Clinic Foundation
RECRUITING

Cleveland, Ohio, 44195, United States
Clínico Virgen de La Arrixaca
RECRUITING

El Palmar, Murcia, 30120, Spain
European Institute of Oncology (IEO)
RECRUITING

Milan, Italy
Florida Cancer Specialists - South
RECRUITING

Fort Myers, Florida, 33901, United States

Contact Email: •••••@•••••
Florida Cancer Specialists Research East
RECRUITING

West Palm Beach, Florida, 33401, United States

Contact Email: •••••@•••••
Gangnam Severance Hospital
RECRUITING

Seoul, 06273, South Korea
Gdański Uniwersytet Medyczny
RECRUITING

Gdansk, 80-214, Poland
Greater Glasgow and Clyde (GGC)
RECRUITING

Glasgow, Scotland, G120YN, United Kingdom
H. Vall d´ Hebron
RECRUITING

Barcelona, Spain
H. de Donostia
RECRUITING

Donostia / San Sebastian, San Sebastian, 20014, Spain
H.U. Ramón y Cajal
RECRUITING

Madrid, Spain
HonorHealth
RECRUITING

Phoenix, Arizona, 85016, United States
Hope Cancer Trials Centre
RECRUITING

Leicester, LE2 7LX, United Kingdom
Hospital Clínico Universitario de Santiago
RECRUITING

Santiago de Compostela, 15706, Spain
Hospital Clínico Universitario de Valencia
RECRUITING

Valencia, 46010, Spain

Contact Email: •••••@•••••
Hospital Universitario Reina Sofía
RECRUITING

Córdoba, Spain
Houston Methodist
RECRUITING

Houston, Texas, 77030, United States
Humanitas San Pio X
RECRUITING

Milan, 20159, Italy
INT Napoli Hospital
RECRUITING

Naples, Italy
IRCCS Gemelli
RECRUITING

Roma, 00168, Italy
Icon Cancer Centre Wesley
RECRUITING

Auchenflower, Queensland, 4066, Australia

Contact Email: •••••@•••••
Institut Curie
RECRUITING

Paris, France
Intermountain Medical Center
RECRUITING

Murray, Utah, 84107, United States
Istituti Fisioterapici Ospitalieri
RECRUITING

Rome, 00144, Italy
Istituto Nazionale dei Tumori
RECRUITING

Milan, 20133, Italy
Istituto Oncologico Veneto (IOV)
RECRUITING

Padova, 35128, Italy
Karmanos Cancer Center
RECRUITING

Detroit, Michigan, 48201, United States
Kliniken Essen-Mitte
RECRUITING

Essen, 45136, Germany
Louisiana State University
RECRUITING

New Orleans, Louisiana, 70112, United States
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
McGill University Health Centre
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Minnesota Oncology Hematology
RECRUITING

Minneapolis, Minnesota, 55404, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
Mount Sinai
RECRUITING

Miami Beach, Florida, 33140, United States
Netherlands Cancer Insitute
RECRUITING

Amsterdam, 1066, Netherlands
NorthShore University HealthSystem
RECRUITING

Evanston, Illinois, 60201, United States
Northwest Cancer Specialists
RECRUITING

Portland, Oregon, 97227, United States
Ohio State
RECRUITING

Hilliard, Ohio, 43026, United States
Osaka Medical Center
RECRUITING

Osaka, Japan
Peter MacCallum Cancer Centre
RECRUITING

Melbourne, Victoria, 3000, Australia
Prince of Wales Hospital
RECRUITING

Randwick, New South Wales, 2031, Australia
Princess Margaret Cancer Center
RECRUITING

Toronto, Ontario, M5G 1X6, Canada
Radboud UMC
RECRUITING

Nijmegen, 6525 GA, Netherlands
Roswell Park Cancer Institute
ACTIVE_NOT_RECRUITING

Buffalo, New York, 14263, United States
Royal Marsden Hospital
RECRUITING

London, SW7 3RP, United Kingdom
Royal Marsden Hospital
RECRUITING

Sutton, SM2 5PT, United Kingdom
S.C.D.U. Oncologia
RECRUITING

Torino, 10128, Italy
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
San Raffaele Hospital
RECRUITING

Milan, 20132, Italy
Seoul National University Bundang Hospital
RECRUITING

Seongnam, 13620, South Korea
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
RECRUITING

Baltimore, Maryland, 21287, United States

Contact Email: •••••@•••••
Siedleckie Centrum Onkologii
RECRUITING

Siedlce, 98-110, Poland
Sir Charles Gairdner Hospital
RECRUITING

Nedlands, Western Australia, 6009, Australia
Site Georges François Leclerc
RECRUITING

Dijon, 21079, France
Spedali Civili
RECRUITING

Brescia, 25123, Italy
St. James's Hospital
RECRUITING

Dublin, 08, Ireland
Texas Oncology
RECRUITING

San Antonio, Texas, 78229, United States
Texas Oncology
RECRUITING

The Woodlands, Texas, 77380, United States
Texas Oncology
RECRUITING

Tyler, Texas, 75702, United States
Texas Oncology Central
RECRUITING

Austin, Texas, 78731, United States
Texas Oncology-Fort Worth Cancer Center
RECRUITING

Fort Worth, Texas, 76104, United States
The Christie NHS Foundation Trust
RECRUITING

Manchester, United Kingdom
The Jikei University Hospital
RECRUITING

Tokyo, 3-19-18, Japan
The Mie University Hospital
RECRUITING

Tsu, Mie-ken, 514-8507, Japan
Tohoku University Hospital
RECRUITING

Miyagi, 980-8574, Japan
UC Davis
RECRUITING

Sacramento, California, 95817, United States
UCLA Health
RECRUITING

Los Angeles, California, 90095, United States
UMC Hamburg-Eppendorf
RECRUITING

Hamburg, 20246, Germany
UZA
RECRUITING

Edegem, 2650, Belgium
University College London Hospitals NHS Foundation Trust
RECRUITING

London, NW1 2PG, United Kingdom
University Hospital Ghent
RECRUITING

Ghent, 9000, Belgium
University of Arkansas
RECRUITING

Little Rock, Arkansas, 72205, United States
University of California, San Francisco
ACTIVE_NOT_RECRUITING

San Francisco, California, 94143, United States
University of Edinburgh Cancer Research Centre
RECRUITING

Edinburgh, United Kingdom
University of Oklahoma Medical Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Virginia Health System
RECRUITING

Charlottesville, Virginia, 22908, United States
Universitätsfrauenkinik Ulm
RECRUITING

Ulm, 89075, Germany
Universitätsklinikum Carl Gustav Carus
RECRUITING

Dresden, 01307, Germany
Universitätsklinikum Mannheim GmbH
RECRUITING

Mannheim, 68167, Germany
Virginia Cancer Specialists, PC
RECRUITING

Gainesville, Virginia, 20155, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States
Willamette Valley Cancer Institute
RECRUITING

Eugene, Oregon, 97401, United States
Winship Cancer Institute at Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Yale University
RECRUITING

New Haven, Connecticut, 06520, United States
Yonsei University Severance Hospital
RECRUITING

Seoul, 03722, South Korea

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