Cholesterol drug takes aim at cancer protein in early trial

NCT ID NCT03560882

First seen May 07, 2026 · Last updated May 07, 2026 · Updated 1 time

Summary

This early-phase study tests whether atorvastatin, a widely used cholesterol medication, can reduce levels of a faulty protein called p53 in people with various cancers, including solid tumors and relapsed acute myeloid leukemia. About 50 participants will take atorvastatin for 1 to 4 weeks before their planned surgery or treatment. The main goal is to measure changes in the mutant p53 protein, not to treat the cancer directly.

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Contacts and locations

Locations

  • University of Kansas Cancer Center - CRC

    Fairway, Kansas, 66205, United States

Conditions

Explore the condition pages connected to this study.