Could a common statin boost hormone therapy in advanced breast cancer?
NCT ID NCT02958852
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This completed Phase 2 trial tested whether adding atorvastatin (a cholesterol-lowering drug) to standard hormone therapy (letrozole or fulvestrant) could improve outcomes in 126 women with advanced, hormone-receptor-positive breast cancer. The main goal was to see if the combination increased the number of patients whose cancer shrank or stayed stable for at least 24 weeks. Researchers also tracked how long it took for the cancer to progress. The study aims to find new ways to overcome resistance to hormone therapy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- atorvastatin (a cholesterol-lowering drug) added to standard endocrine therapy (letrozole or fulvestrant)
- What this could lead to
- If it works, this could point toward a way to overcome resistance to hormone therapy in advanced breast cancer, potentially extending the time the disease is controlled.
- What could go wrong
- This is a small Phase 2 trial (126 participants) and results may not apply to all patients. Adding atorvastatin may not improve outcomes and could cause side effects like muscle pain or liver issues.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Lund University Hospital, Department of Oncology
Lund, 221 85, Sweden
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